Calico Life Sciences Job Trends

Calico is seeking an experienced Process Chemist to join our laboratory-based chemical development team. The ideal candidate brings extensive hands-on experience in process research, route scouting, and scale-up of organic molecules. In this role, you will design, optimize, and execute synthetic processes that enable efficient, safe, and scalable manufacturing of small-molecule intermediates and APIs. This is a lab-focused position requiring strong experimental skills, deep organic chemistry knowledge, and the ability to translate laboratory findings into robust processes. Key Responsibilities Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates Perform laboratory experiments to improve yields, selectivity, throughput, and...

We are seeking a scientist to join our Peptide Chemistry team. In this role, you will drive peptide drug discovery projects that sit at the nexus of empirical medicinal chemistry and Calico’s proprietary Machine Learning (ML) peptide design platform. You will collaborate cross-functionally with ML scientists, medicinal chemists, automation specialists, and biologists to explore structure-activity relationships (SAR). By leveraging a rapid design-make-test cycle, you will accelerate the optimization of therapeutic peptides and contribute to the evolution of a world-class synthetic engine. Key Responsibilities Drive Discovery Lead peptide drug discovery campaigns from initial hit identification through to IND-enabling studies Innovate Synthetic...

Calico is seeking a Principal Scientist, Drug Metabolism and Pharmacokinetics to join our Drug Discovery team. This position is a unique opportunity to shape the DMPK strategy and contribute to the development of innovative therapeutics. This role will function as an individual contributor, collaborating closely with external partners such as Pharma and CROs. Position Responsibilities Strategic Leadership Develop and implement the DMPK strategy to support drug discovery and development programs Provide expert DMPK guidance and input to project teams Represent the DMPK function in cross-functional meetings and interactions with external stakeholders Stay abreast of the latest advancements in DMPK science...