Generate Biomedicines Job Trends

The Senior Director, Biostatistics is a statistical leader responsible for defining and executing statistical strategy for late-stage development program , and regulatory readiness . This Senior Director, Biostatistics will report to Head of Biometrics and expected to partner closely with Clinical Development, Regulatory Affairs, Translational Medicine, and Clinical Pharmacology to ensure scientific rigorous trial execution , and informed decision-making from early development through registration. The Senior Director will be directly responsible for critical statistical deliverables, demonstrat ing both strategic leade rship and hands-on ownership and ensur ing alignment across internal teams and external partners. Here's how you'll contribute...

We are seeking an inventive Computational Protein Design Scientist to join our team working at the interface of computational protein design, machine learning, and experimental biology. In this role, you will use your computational expertise and in-depth biochemical understanding of proteins to drive computational protein design strategy for therapeutic programs while helping develop reusable design capabilities to unlock novel design challenges. The role interfaces between our machine learning and experimental platform teams, working closely to efficiently integrate AI-designed proteins and experimental data. You will combine hands-on protein design with computational experimentation and close partnership across program, experimental, and computational teams....

Generate is seeking a creative and rigorous scientist to develop computational technologies and lead applied platform research that expand what protein therapeutics can do. You will develop reusable methods, scoring and evaluation tools, model benchmarks, agentic systems, and scientific workflows for protein design, engineering, and optimization. Your work will span creating new proteins, modifying existing molecules, and integrating molecular components to unlock new therapeutic applications. At Generate, model development, protein design, high-throughput experimentation, structural characterization, and therapeutic development operate within one organization. This role offers the opportunity not only to advance computational methods, but to see them shape what proteins...

The Functional Bioassays team is seeking a Scientist II to develop, optimize, and execute functional assays across Generate’s therapeutic portfolio. This bench-focused role will generate high-quality data to guide protein design and program decisions, including AI/ML-enabled design cycles. The scientist will design, optimize, and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze results; and support automation integration across programs. Work may include ion-channel, GPCR, ADC-related, and other functional assay platforms as portfolio needs evolve. Approximately 80–90% of this role will be laboratory-based. The scientist will collaborate with colleagues across Therapeutics, Technology, and cross-functional program teams to deliver well-controlled...

GenerateBiomedicines is seeking a Scientist I with expertise in cancer biology to support the discovery and development of protein-based oncology therapeutics. As a member of a multidisciplinary team, this individual will plan and execute cellular assays, interpret results, and generate reproducible data that inform project decisions. This highly laboratory-focused role requires sound scientific judgment, rigorous documentation, and effective collaboration. The core focus will be oncology, with opportunities for a curious scientist to expand their drug discovery and development experience across other therapeutic areas as project needs evolve. Here's how you will contribute Establish, maintain, and characterize cancer cell lines, tumor...

Generate Biomedicines is looking for a talented Senior Scientist I to join the Protein Analytics & Biophysics team within Protein Sciences. This role will lead and contribute to analytical characterization, separation science, and biophysical workflows that assess protein quality, stability, developability, and molecular interactions in support of discovery programs and Generate Biomedicines’ machine learning-powered platform. The successful candidate will bring broad technical expertise, strong scientific judgment, and the ability to represent Protein Analytics & Biophysics on cross-functional project teams. The role is hands-on and collaborative, with responsibility for advancing methods, developing fit-for-purpose workflows, troubleshooting complex experiments, interpreting data, and helping...

Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department. This individual will provide scientific and strategic leadership for protein–protein interaction, target-binding, and cell-binding measurements across multiple biotherapeutic discovery and development programs. The role will combine hands-on technical expertise, novel technology development, cross-functional program leadership, and direct management of junior scientists and research associates. The successful candidate will be an established industry expert in quantitative biophysical assay development, particularly for challenging systems such as integral membrane proteins, lipid- associated targets, detergent-solubilized proteins, and multispecific molecules. Here's how you will contribute...

Generate’s Prototyping Lab builds the experimental systems that let us measure protein function at unprecedented scale. By combining synthetic biology, large DNA libraries, high-throughput assays, and machine learning, the team creates workflows that turn complex biological questions into rich, usable datasets. We’re looking for two Scientists with a strong record in experimental synthetic biology to develop pooled screens capable of testing hundreds of thousands of protein variants in parallel to identify protein binders and modulators. You’ll shape these experiments via DNA library design, pooled in vitro protein display, and NGS-based enrichment analysis. For one of the two roles, we...

The Associate Director will lead a talented scientific team working at the intersection of biological engineering, protein science, automation, and data-enabled discovery. You will help define how difficult and diverse protein targets are designed, produced, characterized, and delivered to project teams with greater speed, scale, quality, and scientific insight, working at the intersection of biological engineering, protein science, automation, and data-enabled discovery. Your leadership will directly influence critical program decisions, the success of novel protein modalities in discovery, the technologies and capabilities we build, and the inclusive, high-performance culture we create. At GenerateBiomedicines, this is an opportunity to combine deep...