Vertex Job Trends

Role Summary The Senior Director, Human Resources Business Partner (HRBP) provides strategic HR partnership to leaders across Global Commercial Strategy, U.S. Pricing & Access / Government Affairs, Global Pricing, and Health Economics & Outcomes Research (HEOR) . Reporting to the Head of HR for Commercialization, this role focuses on talent strategy, organizational design, and supporting commercial transformation efforts . This role partners closely with the VP of Commercial Transformation to align people and organizational priorities with the broader Commercial Transformation agenda, and in support of the resources within the transformation office. Key Responsibilities HR Business Partnership Serve as a strategic...

The Senior Director, Integrated Customer Experience (ICX) Activation, is responsible for translating Vertex’s ICX strategy and priority customer journeys into the digital capabilities, platform requirements, and business roadmaps needed to activate them at scale. This role owns the ICX activation blueprint and roadmap and partners closely with DTE and I&A to enable orchestrated, personalized, and AI-enabled customer engagement across channels. The role also owns the business roadmap for website product strategy, marketing automation, customer data and activation capabilities, and the ICX agentic AI portfolio. This leader oversees external partners, drives cross-functional alignment, and leads a team of 10 direct reports....

Vertex is seeking experienced commercial leader to join our US Pain Business Unit to support a new treatment option for acute pain, Journavx. The Group Purchasing Organization (GPO) Account Lead will be responsible for supporting the development of the GPO strategy and establishing and maintaining relationships with key GPO decision makers. This role involves collaborating with GPO stakeholders to deliver access for the US business unit, with innovative pricing and access strategies. We are looking for candidates with a proven history of delivering exceptional results, building strategic relationships, and embodying the Vertex values to earn the trust of GPOs and...

The Operations and Analytics Associate Director leads sophisticated analyses, develops financial models, and generates insights to address strategic market access questions, presenting findings effectively and succinctly to leadership. The role requires the extraction and synthesis of relevant data to deliver timely insights into the underlying factors driving forecasts and variances to plan, while delivering forward-looking perspectives that inform and drive key business decisions— supporting both approved and potential future indications Key Duties and Responsibilities Work independently to surface insights from internal data sets and secondary sources that answer key business questions and inform access and commercial decisions Play a key...

Vertex is seeking a Sr. Manager, Contract Management to support a few business functions. In this role, you will manage the full contract lifecycle for a wide range of business agreements collaborating closely with colleagues across Legal, OBIE and Strategic Sourcing. The ideal candidate will bring strong contract administration experience, sound business judgment, and the ability to collaborate effectively with cross-functional stakeholders in a fast-paced environment. This position requires a highly organized professional who can balance competing priorities, ensure compliance with internal policies, and help drive efficient, consistent contracting processes. Key Duties and Responsibilities Lead the end-to-end contract lifecycle for...

We are seeking a unique individual with a passion for data and AI technology who can help our team drive forward enterprise-scale AI adoption of our data & AI platform. Vertex Pharmaceuticals is in a transformational period where we are accelerating our capabilities, technologies, and data to augment our scientific mission, enable Vertex to grow in scale, and continue to be on the forefront of science, medicine, and technology. As part of this effort, it is critical that users have data “at their fingertips”, with the patterns and technology to support AI adoption at scale. As a Senior Principal AI...

The Quality Analytics Manager utilizes data analysis skills and tools to evaluate Vertex operations, processes, and systems and recommends strategic process improvements based on research findings. This role is a key contributor in driving data-centric decision making within the Quality organization. The role also advises and supports business partners in design and delivery of data models and data analysis that enhance Vertex delivery and oversight. Key Duties and Responsibilities Identifies, analyzes, and interprets trends and patterns in complex data sets and prepares ongoing reports and data visualizations to support decision-making Develops and implements data analyses, data collection systems and other...

Vertex is seeking a Commercial Training, Senior Manager to enhance the skills, capabilities, and knowledge of customer-facing teams supporting reimbursement and patient access. This role is responsible for developing, implementing, and facilitating impactful training programs that support field readiness, onboarding, and ongoing capability development for field reimbursement and patient support audiences. The ideal candidate brings strong expertise in reimbursement, access, training strategy, and adult learning, with the ability to translate complex concepts into practical, field-relevant learning experiences. Work Model On-site or Hybrid Key Responsibilities Partner with cross-functional stakeholders to identify training needs and recommend learning solutions for field reimbursement teams...

Employee Relations Senior Manager The Employee Relations Senior Manager serves as a trusted advisor and strategic partner to leaders, HR, Legal, Compliance, and employees in fostering a fair, respectful, and compliant workplace. This role leads complex employee relations matters, workplace investigations, and policy interpretation while helping the organization proactively identify and address workforce risks and trends. The Senior Manager plays a critical role in safeguarding employee experience, ensuring consistent application of policies and practices, and influencing organizational culture through objective, evidence-based decision making. This individual will also help modernize and scale employee relations processes, tools, and reporting to improve...

The Associate Director, External Innovation reports into the Executive Director, External Innovation and Portfolio Operations , and is responsible for conducting scientific, clinical and commercial analysis, monitoring company/technology ev o lu t ion across the bio pharma landscape and contribute to the evaluation of collaboration /acquisition opportunities that are aligned with the corporate strategy. As a member of the External Innovation team, y ou will contribute across phases of evaluation of external opportunities , participate to cross-functional projects with the transaction s and alliance management teams , and manage cross-functional relationships to ensure communication and alignment across stakeholders. Responsibilities Conducts...

Our Medical Writing team at Vertex is in-house, and our Writers are strategic partners in our drug development process, collaborating with cross functional teams, authoring and driving clinical & regulatory documents to bring innovative new therapies to patients. This is a hybrid position which allows 2 days per week remote work and 3 days per week in our Boston Seaport office. Relocation assistance is available. The Director, Medical Writing Science has responsibility for the management, oversight, operation, and direction of a group within the department. This role is held accountable for the results of the group and the work performance...

The Manager, Disease Strategy Finance is a key member of Vertex's Disease Strategy Finance Team, providing financial and strategic insights to inform Disease Strategy Teams (“DSTs”) on key decisions. This role will work closely with Directors on the DST Finance team to conduct financial modeling, forecasting, and scenario-based valuations. The Manager, Disease Strategy Finance will also play a critical role in creation of the Annual Budget, Long-Term Plan (LRP), and other financial forecasts in collaboration with colleagues. The role will partner closely with members of the global COFO organization, including finance teams supporting R&D, Biopharmaceutical Sciences and Manufacturing, Corporate, and...

The Executive Assistant provides specialized, independent administrative/business support to 2-3 Vice Presidents supporting multi- therapeutic areas. Key Duties and Responsibilities Serves as the primary support professional for a Sr. Vice President, independently handling a full range administrative activities As the delegate for the executive, handles details of a highly confidential and critical nature related to the function/department Interacts regularly with senior leaders inside and outside the Company in coordinating the affairs of the executive Manages the executive's complex and detailed calendar, frequently coordinating logistics and sharing information with other assistants and leaders both internally and externally; coordinates complex travel and...

The Medical Writing Science Manager is responsible for preparing moderately complex clinical and regulatory documents and represents Medical Writing Science as a cross-functional team member at clinical study level activities. This role contributes scientific knowledge and analytical skills to the development of clinical regulatory documentation, under minimal supervision. Key Duties and Responsibilities Authors moderately complex clinical regulatory documents (e.g., including clinical study protocols, clinical study reports, investigator’s brochures, and sections of regulatory submissions) in partnership with key cross-functional stakeholders Serves as the lead Medical Writing Scientist for moderately complex clinical studies Supports Medical Lead with review and interpretation of clinical...

The Senior Manager is a key member of Vertex's Financial Planning & Analysis team, providing financial direction and strategic insight including identification of key value drivers and Business KPIs, helping functions deliver their short term and long term goals and influencing strategy. This role will help drive our annual budget process and will partner closely with functional teams to drive the financial performance management process for responsible functions (objective setting, budget vs. actuals, etc.), including the monthly forecast process, with a focus on influencing business operations and decisions through an understanding of the key drivers of short term performance and...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

This is a unique opportunity to shape the future of leadership at Vertex. As the Enterprise Talent Management Director, you will lead programs that ensure we have the leadership pipeline, succession strength, and talent capabilities needed to deliver on our long-term business ambitions. Partnering closely with senior leaders, HR Business Partners, and Centers of Excellence, you will drive enterprise talent reviews, succession planning, leadership pipeline development, executive onboarding, and senior leader development. This highly visible role combines strategic thinking, data-driven decision making, and influential partnership to identify and accelerate high-potential talent, strengthen leadership readiness, and build capabilities that fuel growth....

The Marketing Senior Manager will support the delivery of the marketing strategy by overseeing development of HCP and/or patient and caregiver tactics, and ensuring those tactics are delivered to customers effectively and monitored for effectiveness. Key Duties and Responsibilities Develops and updates marketing materials which are aligned with marketing strategy and business objectives (including branded websites, interactive visual aids, sales brochures, etc.) Enhances customer engagement by ensuring marketing pieces have been uploaded to the CRM platform, administering speakers programs, coordinating conference activities (including promotional booths, conference materials) Analyzes complex digital and print material usage metrics for performance reporting and assessing...

This role also prefers experience calling on the state of Hawaii. The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or...

Vertex is seeking an exceptional scientific leader to drive the development and incorporation of human disease models and assays into drug discovery programs. The Sr. Director, Pharmacology will lead a department responsible for the design, development, and execution of in vitro and in vivo assays that support the progression and optimization of human therapeutics, including assays used to determine drug potency, efficacy, and mechanism of action. This leader will also serve as a member of the San Diego biology leadership team and help shape site research direction and cross-departmental projects. Key Duties & Responsibilities Direct pharmacology strategy, including assays that...

Vertex is seeking a highly motivated Discovery Immunology Principal Research Scientist, to lead immunology discovery programs focused on autoimmune diseases. The successful candidate will shape scientific strategy, identify and validate therapeutic targets, investigate disease mechanisms, and advance early drug discovery. This role requires deep expertise in immunology, translational science, and experimental biology, as well as a record of leading complex research in a collaborative biotechnology environment. The position partners closely with teams in biology, translational sciences, bioinformatics, drug discovery, and project leadership. This is an on-site, laboratory-based role. Key Duties and Responsibilities Lead discovery immunology programs from target identification...

The Senior Administrative Assistant will serve as a trusted administrative partner to the Executive Director, Seattle Research Site Head. The role is responsible for calendar and travel management, meeting and event coordination, contracting and invoice administration, executive preparedness, and broader team operations. The successful candidate will work with a high degree of independence, judgment, discretion, and attention to detail while managing competing priorities and interacting professionally with senior internal and external stakeholders. Key Duties and Responsibilities Executive and Stakeholder Support Serve as a primary administrative point of contact for supported leaders, anticipating needs, applying sound judgment, and appropriately screening, routing,...

The Executive Medical Director, Clinical Development will provide high-level input on clinical development strategies to povetacicept renal programs, in conjunction with other relevant functional area leaders in Medical Affairs, Regulatory, Global Patient Safety, Clinical Operations, Exploratory Development, Commercial, Pharmaceutical Development, Research, Business Development, and Marketing. Initiate and lead innovative approaches to clinical development. Key Duties and Responsibilities Broad and comprehensive understanding of the drug development process Well-respected authority in the external clinical development community Provide clinical development recommendations to project teams, including optimizing study design and conduct for efficiency and effectiveness. Participate in planning for worldwide clinical development activities Provide...

We are seeking a highly motivated and experienced cell therapy leader to join our Vertex Boston Leiden Center location at the Director level. The Director, Stem Cell Research will work within the Type 1 diabetes (T1D) program to support our biology pipeline including molecular characterization of stem cell-derived islet manufacturing as well as discovery of novel biomarkers and associated assays. You will lead a highly skilled and motivated team coordinating collaborative research across multiple research groups. The Director should be a creative, innovative, self-motivated scientist with an outstanding record of bringing research discoveries from pre-clinical to clinical and/or commercial manufacturing....

The Senior Medical Director will define the clinical development strategy of an asset, work with cross-functional multidisciplinary teams to define overall asset strategy as well as clinical trials strategy, design and execution, and may serve as the Medical Lead for clinical trials that will be conducted with these compounds. Key Duties and Responsibilities Defines a clinical development strategy and prepare the clinical development plans, in conjunction with other relevant functional areas Participates in the development of study protocols, statistical analysis plans, investigator's brochures, and other key study documents in conjunction with other line functions and with minimal guidance Leads the...

Location Boston Fan Pier / Hybrid Department Nonclinical Safety / Toxicology Travel 30%–50% We are seeking a Nonclinical Toxicology Study Monitoring Scientist to play a critical role in supporting the safety assessment of both large and small molecule modalities including cell and gene therapies across the development pipeline by providing scientific, technical, and operational oversight of outsourced nonclinical studies. This individual will partner closely with project toxicologists, cross-functional internal teams, and external Contract Research Organizations (CROs) to help ensure studies are executed to high scientific and operational standards, in alignment with study objectives, timelines, and regulatory expectations. This role...

The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program. Key Duties and Responsibilities Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and...

The Principal Biostatistician will perform advanced scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with some guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Conducts advanced scientific and operational statistical work for multiple clinical trials, observational studies, or real world data (RWD) investigations, including the design, development and execution of the technical/statistical infrastructure....

The Director, Package Engineering leads a technical team of packaging engineers responsible for successful late-stage development, commercialization and supply of Vertex products. This role models leadership behaviors, builds an organization capable of ensuring future success, develops leaders, and drives efficiency and risk reduction into relevant internal and external processes. This role is a major contributor to the Manufacturing Science and Technology strategy development and to the collective success of Commercial Manufacturing & Technical Operations, Supply Chain, and Vertex. Key Duties and Responsibilities Responsible for technical packaging engineering and leverages knowledge to build alignment across technical areas or functions Supports Regulatory...

The Principal Analyst, Digital Discoverability & AI Optimization leads Vertex’s enterprise strategy and standards for digital discoverability across traditional search engines and emerging AI-powered answer and retrieval platforms. This role will define and scale capabilities that improve how Vertex websites, content, and digital assets are discovered, retrieved, interpreted, cited, and recommended. The role serves as the enterprise lead for Answer Engine Optimization (AEO), Generative Engine Optimization (GEO), AI search optimization, AI-ready website architecture, and LLM ingestion readiness. This position partners across Digital Customer Engagement, Commercial, Medical, Content Automation & Lifecycle, Omnichannel Activation, Digital Experience & Data Foundations, Analytics, Legal, Privacy,...

The Discovery Immunology Group is seeking a highly motivated Scientist to assist in the discovery and development of novel protein therapeutics to treat patients with autoimmune disease. This is a laboratory-based role where the successful candidate will contribute directly to research efforts by designing, executing, and analyzing experiments related to immune mechanisms, target validation, and therapeutic development. The position requires strong attention to detail and ability to multitask while working in a highly collaborative environment. Key Duties and Responsibilities Isolate, culture, and manipulate primary human immune cells and cell lines. Design and execute experiments to interrogate immune cell phenotype and...

Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. At our San Diego site, the Engineering & Applied Physics group is a dynamic, fast-paced team of 20 applied physicists and mechanical, electrical, and automation engineers. Together, we design and develop custom instruments that integrate cutting-edge technology and full automation to accelerate Vertex’s internal drug discovery pipeline. These instruments are tailored to specific project needs, enabling capabilities that are not commercially available. We are seeking an experienced and innovative Principal Scientist with expertise in optical design, microscopy, and functional...

Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Our teams bring together deep scientific expertise, advanced technologies, and a commitment to improving patient outcomes through discovery, development, and delivery of innovative therapies. Within Vertex, the Biomarkers organization plays an important role in advancing clinical development through biomarker research, assay development, and cross-functional collaboration. Role Summary Vertex is seeking a strategic, hands-on Biomarkers Senior Research Lab Scientist to develop and optimize biomarker assays for clinical trials at Vertex. The candidate will design and execute experiments within our...

Vertex is seeking a highly motivated Stem Cell Research Scientist to join our research organization and advance innovative therapeutic approaches for type 1 diabetes (T1D). In this role, you will contribute to the discovery and development of cell-based therapies by applying expertise in stem cell biology, islet differentiation, cellular assay development, and translational research. The ideal candidate will bring strong technical depth in pluripotent stem cell culture and differentiation, experimental design, and functional characterization of stem cell-derived models, along with a passion for translating cutting-edge science into meaningful therapies for patients. This scientist will work closely with cross-functional partners across...

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

The Associate Director, GxP Operations Support Manufacturing Systems will provide strategic leadership for the design, delivery, administration, and continuous improvement of the site Manufacturing Execution Systems (MES) and manufacturing control system platforms supporting commercial and clinical operations. This role serves as a key business and technical leader responsible for advancing agile digital manufacturing capabilities. The Associate Director will partner across Manufacturing, Quality, Validation, Information Technology, and Engineering organizations to ensure compliant, reliable, and scalable manufacturing systems. The role will also support lifecycle management of manufacturing systems including data integrity, industrial networking, historian platform integration, and cybersecurity. Key Duties and Responsibilities...

For this Director-level role, w e are seeking a scientific and technical expert to lead our agentic AI co-scientist initiative across our scientific organization . This individual will serve as the scientific lead on the project, defining and influencing the strategy, architecture, evaluation framework, and delivery plan for co-scientist capabilities across multiple scientific use cases and functions . This effort will span both internal development of capabilities and rigorous evaluation of externally available tools. A s the senior scientific leader of the effort, this individual will align cross-functional stakeholders, prioritize scientific needs and capabilities, and drive measurable progress, adoption, and...

Vertex is seeking a Director, Medicinal Chemistry to provide people management and strategic leadership for small-molecule discovery programs and to help advance compounds from early discovery through candidate selection. This role is responsible for defining and executing medicinal chemistry strategy, leading compound design and optimization, and advancing programs through close partnership with cross-functional teams. The successful candidate will manage a team and bring deep scientific expertise, strong leadership capabilities, and a proven track record of advancing discovery-stage programs in a fast-paced research environment. This is an on-site role. Key Responsibilities Lead medicinal chemistry strategy for small-molecule discovery programs aligned with...

The Research Scientist, Exploratory Biology will be responsible for identifying new disease opportunities that align with Vertex research strategy, designing and executing focused research studies to advance understanding of disease biology and target mechanisms, and contributing to informed go/no go decisions. This role will contribute to the development of biochemical and cellular assays, generate high-quality experimental data, and help shape new scientific directions through rigorous analysis and creative problem solving. The successful candidate will work with a strong degree of independence while collaborating effectively across multidisciplinary teams in a fast-paced discovery environment. Key Duties & Responsibilities Identify and evaluate novel...

The Global Patient Safety Individual Case Safety Report (ICSR) Manager is responsible for performing Individual Case Safety Report (ICSR) processing activities, including case book-in, triage, case entry (structured field data-entry, event coding, narrative writing, and pursuit of follow-up information), finalization and reporting. The Global Patient Safety ICSR Manager works with a high degree of independence and is proficient at troubleshooting problems to create and execute improved internal procedures, and to ensure compliance with applicable regulatory requirements. This individual ensures that all work performed is in accordance with relevant regulatory guidelines. By virtue of their experience, the Global Patient Safety ICSR...

The International PV Senior Specialist is responsible for supporting build-out and management of the GPS International PV structure. The International PV Senior Specialist works with a degree of independence and supports troubleshooting problems and improving internal procedures, to ensure compliance with applicable regulatory requirements. This individual helps ensure that all work performed is in accordance with relevant regulatory guidelines. By virtue of their experience, the International PV Senior Specialist is expected to complete work in a resourceful, self-sufficient manner. Key Duties and Responsibilities Assists with ensuring that all GPS procedures are compliant with global PV regulations Supports oversight of local...

Vertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on small molecules to develop, test, and deploy AI-enabled solutions that enhance scientific workflows, improve decision-making, and increase productivity. As a scientific developer and trusted scientific computational methods and cheminformatics expert, you will establish AI testing and evaluations strategies and drive the development of high performant, AI-enabled scientific workflows. This is a highly collaborative position at the intersection of computational sciences, research teams, and...

Vertex is seeking a Senior Principal Research Scientist, Medicinal Chemistry to provide scientific leadership in the design and optimization of small-molecule therapeutics across discovery programs. This role will play a critical part in advancing high-quality drug candidates from early discovery through candidate selection, while partnering across multidisciplinary teams to solve complex scientific challenges. The ideal candidate is an accomplished medicinal chemist with deep expertise in small-molecule drug discovery, a strong record of scientific innovation, and demonstrated success in a fast-paced and matrixed research environment. This is an on-site role. Key Responsibilities Lead medicinal chemistry strategy for small-molecule discovery programs aligned...

Vertex is seeking an Associate Director of Supply Chain to lead the development of upstream supply strategy for the Pain portfolio and support the Program Lead on end-to-end strategic initiatives. This role is ideal for a strategic, collaborative leader who thrives in a fast-paced, evolving environment and brings strong expertise in scenario planning, cross-functional influence, ERP systems, and executive communication. The successful candidate will play a critical role in aligning supply chain strategy with broader program objectives, enabling informed decision-making, and ensuring continuity of supply across a complex and highly regulated environment. This is a Hybrid position that requires 3...

Vertex is seeking a scientific leader to accelerate the application of AI and agentic systems across drug discovery. Working at the intersection of Computational Drug Design, project teams, Data & Methods, and Digital Technology & Engineering, this individual will leverage deep expertise in computational chemistry, cheminformatics, and AI-driven drug discovery to identify high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the primary focus will be small-molecule drug discovery, the successful candidate will also help extend relevant AI and agentic capabilities...

We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using a broad range of computational approaches including molecular modeling, cheminformatics, data science, and AI-enabled methods. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively within the global Data and Computational Sciences group to provide expertise in data analysis, computational chemistry and AI method development. This individual must demonstrate strong...

We are seeking a Computational Genomics Research Scientist to support the development of transformative cell and gene therapies across Vertex's research portfolio. This Boston-based position is part of the global Data and Computational Sciences organization and will collaborate closely with research teams spanning stem cell biology, immunology, gene editing, and pre-clinical development to design studies, execute and analyze complex genomic analyses, and ultimately generate biological insights that drive early research across multiple disease programs. As an embedded computational scientist, you will be responsible for performing bulk and single-cell sequencing analyses , spatial transcriptomics, and multiomic profiling to help uncover the...

The Senior Director, Immunology will oversee multiple research programs and initiatives that support the research and development of the Vertex portfolio, and collaborate closely with manufacturing, process and analytical development colleagues to support the development of advanced therapies. This role will be responsible for driving execution of current projects and leading the identification of new opportunities. This individual will help define and drive immunology research strategies, lead the development of novel immunomodulatory approaches to enable transformative advances in allogeneic transplantation, and provide scientific leadership across a diverse portfolio of discovery and development programs. Through deep scientific expertise, strategic vision, and...

The Audit & Compliance Manager manages and coordinates audit, inspection, and compliance activities across Data, Technology & Engineering (DTE) and business functions. This role serves as the primary liaison between operational teams and auditors, ensuring timely preparation, execution, response, and remediation of Internal Audits, GxP audits, and regulatory inspections. The role partners closely with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations are fulfilled. General Responsibilities Serve as the primary DTE point of contact for IT-related audit, inspection, and compliance requests across GxP, Internal Audit, and operational audit...

The Strategic Operations Manager, Preclinical Sciences will play a critical role in driving operational excellence across the Preclinical Sciences organization. This position will partner closely with Procurement, Legal, Outsourced Contracting, Lab Operations, and Records Management to support business operations, improve processes, and enable efficient execution of departmental priorities. The ideal candidate is a highly organized and agile operations professional who thrives in a fast-paced environment , can manage multiple priorities simultaneously, and is experienced in supporting change management initiatives and driving efficiencies across cross-functional teams. Key Duties and Responsibilities Partner with Research & Preclinical Sciences leadership to support strategic and...

We are seeking a Senior Research Scientist in Computational Genomics to join Vertex's Data and Computational Sciences organization at our San Diego research site. In this role, you will work at the intersection of human genetics, genomics, and modern computational approaches, including emerging AI technologies, to accelerate the development of transformative therapies for serious human diseases. Working closely with cross-functional disease project teams, you will help shape the development of novel therapies in areas including lung diseases and pain by designing human genetic and genomics studies and translating complex datasets into insights that inform program strategy, target evaluation, biomarker development,...

Vertex is seeking a highly experienced and motivated Principal Research Associate to support discovery and optimization of Lipid Nanoparticles (LNPs) by developing, optimizing, and applying advanced in vitro cellular models and executing cell-based assays to evaluate delivery, uptake, and pharmacological activity of LNPs. This role is primarily laboratory-based and will focus on technical execution and method development across screening workflows and related delivery biology studies. Key Duties and Responsibilities Establish, optimize, and apply advanced 2D and 3D cellular models using primary cells, organoids/spheroids, and advanced cell culture platforms. Execute and optimize automated cell-based assays and lead screening activities by generating...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Senior Director, Analytical Development is a senior leadership role within the Cell and Gene Therapy Analytical Development function and will be responsible for setting and driving the company’s analytical testing strategy, including manual and automated testing approaches, analytical operations, and implementation of automation capabilities. This leader will oversee teams focused on automation of assays, testing in support of process workstreams, and analytical operations such as reagent and assay control management. The role will work closely with Manufacturing, Process Development, Regulatory, Quality, CMC, and external partners to generate high-quality data that informs strategy and decisions, while advancing next-generation analytical automation...

The Senior Director, Government Pricing will lead the tactical, compliance, and strategic oversight of the Government Pricing and Transparency team. The team is comprised of complementary functions Government Pricing Operations, Compliance, and State Price Transparency. This position will collaborate closely with the Managed Markets Specialty Pharmacy and Payer Field teams, Accounting, Legal, Finance, Global Information Systems, Government Affairs and Public Policy, OBIE, Treasury, Regulatory, Quality, and Pharmaceutical Operations. This role will demonstrate a level of detail, strategic understanding of Vertex business priorities, and executive presence. Key Duties and Responsibilities Serve as subject matter expert on Government Pricing calculations, methodologies, reporting...

The Patient Safety Senior Medical Director will provide leadership for all safety and risk management activities for assigned products, pre- and/or post-approval. This role will lead Risk Management activities, pre-, peri- and post-approval (as applicable) for assigned compound(s) and will provide relatively autonomous leadership of periodic (aggregate) safety report, signaling, labelling and DST activities for assigned compounds, as well as participate in individual case medical review. This role will lead representation, as safety lead, on clinical teams/programs, regulatory filings and submissions and other intra and/or inter-departmental activities and initiatives, including process/SOP development, audits and inspections. Key Duties and Responsibilities Represents...

As the Associate Director of Strategic Sourcing for Cell and Gene Therapy (CGT) Raw Materials, you will be part of a fast-growing and innovative organization at the company’s world headquarters in Boston, MA. The department is committed to a trusting and collaborative culture where growth and development are valued. We engage proactively with stakeholders to understand their needs and deliver results for our company and for patients. If you are looking for an entrepreneurial, hands-on, team-oriented environment where you can make a meaningful impact, this is the right place for you. The role is responsible for raw materials sourcing categories...

As the Sales Planning and Field Effectiveness, Associate Director you will be responsible for the administration, execution, and delivery of incentive compensation, targeting, sales planning, and field effectiveness. This role partners closely with business unit leadership and cross-functional stakeholders to translate brand strategy into practical field execution solutions that improve commercial performance. This position requires a hands-on leader with expertise in pharmaceutical incentive compensation, targeting strategy, sales operations, analytics, and data management. The role supports targeting prioritization, incentive plan design & delivery, performance monitoring, and process improvement to help maximize sales force productivity, customer engagement, and execution quality. This is...

The Epidemiology Forecasting team develops patient population forecasts used to inform commercial opportunity and forecasting, clinical trial planning, long-range planning, regulatory filings, and external communications. The Director, Epidemiology Forecasting is responsible for supporting programs through the execution of strategic plans to obtain scientifically rigorous global estimates of the incidence, prevalence, and population size for diseases being investigated for treatment. The role will report to the Senior Director, Epidemiology Forecasting. Key Responsibilities Lead systematic literature reviews and database/disease registry studies and contribute to primary observational studies to ensure the development of scientifically rigorous estimates of disease incidence, prevalence, and population size...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The GCO AI Enablement and Analytics Associate Director serves as the business-embedded technical expert responsible for advancing AI-enabled business transformation, advanced analytics, automation, and digital capabilities across Global Clinical Operations (GCO). As a key member of the Digitization Strategy Center of Excellence, this role will help shape and execute GCO's AI enablement and analytics strategy to improve the efficiency, effectiveness, and scalability of clinical trial execution. The individual will operate at the intersection of clinical operations, process transformation, analytics, and emerging technologies. This role will provide the technical expertise needed to bridge clinical operations business needs with AI and digital...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Senior Medical Science Liaison (Sr MSL) will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide the...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer. Key Duties and Responsibilities Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools) Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group Demonstrates in-depth knowledge of clinical development and medical data Solves complex clinical trial reporting problems...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Manager of Commercial Rebate Operations has a critical role, reporting into the Associate Director, Rebate Operations team within the US Market Access organization. This is an exciting opportunity for a subject matter expert that applies an enterprise-level mindset and technical expertise at the intersection of data, process optimization, automation and innovation. The ideal candidate is passionate about patients, focused on driving for results, and is willing to be involved in hands-on execution while building new functional capabilities. The successful individual must be adept at cross-functional collaboration, while also having a high degree of attention to detail and accuracy to...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

At Vertex, we’re relentless in our pursuit of scientific innovation to create transformative medicines for people with serious diseases. We are currently seeking a Gene Therapy Account Manager (GTAM) to support our Sickle Cell Disease (SCD) and Transfusion-dependent β-thalassemia (TDT) Heme Business Unit. This role is responsible for the Southeast territory which includes FL, GA and AL As part of a national team, the Gene Therapy Account Manager, Associate Director (GTAM) will approach each day with a passion for improving the lives of people living with Sickle Cell Disease and Transfusion-dependent β-thalassemia. This role is focused on Key Account Management...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The successful candidate will work in a team setting and be responsible for coordinating production of program-relevant cell types such as stem cell-derived islets (SC-islet) for use across research team projects. This includes 2D and 3D culture of pluripotent stem cells as well as differentiation for in vitro and in vivo studies. A demonstrated strong understanding of best lab practices to ensure reliability, consistency, efficiency, and quality control, as well as dedication to lab bench work, are required. Key Duties and Responsibilities Culture human stem cells in 2D and/or 3D Completes experiments in a reliable, consistent manner Demonstrates a high...

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition and supporting evidence of Vertex’s innovative renal pipeline asset, povetacicept , a dual inhibitor of the BAFF and APRIL pathways, currently in phase III. This position reports to the Senior Director Global HEOR, Kidney. Key Duties and Responsibilities Leads others to execute complex HEOR evidence generation including, cost-effective analysis and budget impact models, prospective...

Key Responsibilities Perform revenue recognition evaluations under ASC 606 for new product launches, new contracts, and reimbursement agreements Review new agreements and complex gross-to-net matters and help ensure technical accounting conclusions are applied consistently and appropriately by local accounting teams Document accounting policies related to revenue and gross-to-net matters in collaboration with International and North America revenue accounting teams, as needed Partner with cross-functional teams that review and support the contract drafting process Work closely with global accounting, finance, and commercial organizations to support internal and external financial revenue reporting requirements Partner with the SEC Reporting team to prepare revenue-related...

The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program. Key Duties and Responsibilities Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and...

We are seeking a Senior Director / Director to lead the Value Realization Office (VRO) process for material, transformational initiatives across the project lifecycle. This role partners closely with project owners, executive sponsors, Finance, and DTE to define how value will be measured, establish baseline and reporting approaches, and monitor realized value against agreed objectives. The position is central to building a disciplined, consistent approach to value delivery, helping ensure strategic initiatives achieve measurable outcomes and addressing risks or variances when performance is off track. What You’ll Do Lead execution of the Value Realization Framework for in-scope, material, and transformational...

The Director, Commercial Training will work to enhance the skills and knowledge competencies of commercial and other relevant teams. This role will be primarily responsible for developing and executing training and development strategy ensuring commercial teams are equipped to excel. This role will work cross-functionally across a variety of internal stakeholders. This role involves leading a team, managing training portfolios, and fostering collaboration with cross-functional partners to drive exceptional performance. As a people manager within the organization, this role may have financial accountabilities and human resource responsibilities for assigned staff. Key Duties and Responsibilities Creates a comprehensive learning-strategy that supports...