Vertex Job Trends

The Associate Director, Preclinical Sciences, Program Management and Strategic Operations, will be responsible for the integration, creation, and execution of multiple complex pharmaceutical development/regulatory plans. By collaborating closely with Project Leaders, cross-functional Project Team members, and contract research partners, the incumbent develops and maintains fully integrated project plans to ensure that deliverables are successfully executed, are in accordance with project and disease area objectives, and are within budget. The incumbent is also responsible for comprehensive communication, including status reporting, risk management and escalation of issues to cross-functional stakeholders and Senior Management. Key Duties & Responsibilities With support, establish project team...

Role Summary The Senior Director, Human Resources Business Partner (HRBP) provides strategic HR partnership to leaders across Global Commercial Strategy, U.S. Pricing & Access / Government Affairs, Global Pricing, and Health Economics & Outcomes Research (HEOR) . Reporting to the Head of HR for Commercialization, this role focuses on talent strategy, organizational design, and supporting commercial transformation efforts . This role partners closely with the VP of Commercial Transformation to align people and organizational priorities with the broader Commercial Transformation agenda, and in support of the resources within the transformation office. Key Responsibilities HR Business Partnership Serve as a strategic...

The Associate Director, Technical Services is accountable for the technical execution of biologics drug substance manufacturing at external manufacturing partners. This role is responsible for ensuring processes are executed as intended and delivering reliable supply. The Associate Director serves as the technical leader for manufacturing execution, driving performance, standardization, and rapid issue resolution across programs and CDMOs. The Associate Director, Technical Services role is a key member of Vertex’s External Manufacturing Organization (ExM), providing support, strategic insights and enterprise thinking to the Biopharmaceutical Sciences and Manufacturing Operations organization (BSMO). The Associate Director, Technical Services is accountable for the technical execution...

Vertex is seeking a highly motivated Senior Scientist, Immunology to join our research organization and contribute to the discovery and advancement of novel therapies for serious diseases. This individual will play an important role in designing and executing studies that deepen our understanding of immune mechanisms relevant to disease biology and therapeutic intervention. The successful candidate will bring strong expertise in human primary immune cells , innate immunity , and macrophage biology , along with the scientific rigor and creativity needed to support research programs in a dynamic, collaborative environment. This role will work closely with cross-functional teams to generate...

The Operational Area Quality Senior Manager provides quality leadership for assembly manufacturing operations supporting medical device and combination products. The role is responsible for quality oversight of manufacturing operations, product disposition, batch record review, deviations, investigations, CAPAs, change controls, supplier quality, and regulatory compliance while partnering with manufacturing, engineering, supply chain, and external manufacturing partners. The position also supports design quality activities to ensure manufacturing changes remain aligned with design control and risk management requirements throughout the product lifecycle. ⸻ Key Duties and Responsibilities - Lead Quality Assurance support for assembly manufacturing operations of medical device and combination products, ensuring...

The Associate Director Business Development and Strategic Finance is a key member of Vertex's Financial Planning & Analysis organization. The role partners closely with members of the executive team to provide financial direction and strategic insights in support for potential M&A, licensing, collaborations and investments to help drive Vertex external innovation efforts. Key Duties and Responsibilities Partners with Business Development and finance team members to lead complex analysis for a wide range of potential transactions to execute Vertex strategy Brings insights, challenge, alternatives and solutions, not just information to each individual project Leads financial evaluations and serves as main point...

Vertex Pharmaceuticals, Inc. is seeking a highly skilled and proactive Senior Research Associate to join our Human Cell Core, contributing to the development and execution of advanced human cell models at scale. The successful candidate will work in a team setting, maintaining and expanding primary human cells at scale and operating automation-enabled cell culture platforms. Success in this position requires a high degree of reliability, attention to detail, adaptability, problem solving skills and ability to work in a team-oriented environment. Key Responsibilities Work collaboratively as a team to maintain and expand primary human cells at scale Operate state-of-the-art instrumentation and...

The Quality Systems Associate Director supports strategic design of and ensures tactical execution of quality systems, risk management, and quality culture across the Vertex Cell and Gene Therapy (VCGT) organization. The role is responsible for partnering with cross-functional technical development and commercial teams to align and facilitate harmonization of strategy, procedures and processes related to the Quality Management System and to drive Quality improvements. This position reports directly to the Director of Quality. Key Duties & Responsibilities The responsibilities of this position may include, but are not limited to, the following -Process Lead for Annual Product Quality Review (APQR) and...

The Managed Care Contracting Associate Director will provide leadership and management oversight of Market Access Contract processes by facilitating negotiation and administration of all Payer, Provider and Trade & Distribution contracts. This person will partner with, among others, Account Management, Finance, Government Pricing & Rebate Operations, GTN, Legal, Marketing and Payer Marketing to ensure appropriate identification and evaluation of contracting opportunities. These responsibilities will apply across all Vertex marketed product lines and pipeline products. Key Duties and Responsibilities Manage the end-to-end Payer contract development process, including working with cross-functional partners on pre-deal analytics, negotiations, and post-deal analytics as well as...

The Associate Director, Source to Pay Technology will provide technical expertise, delivery, and support for Source-to-Pay AI-powered technologies. This role will focus on the implementation and subsequent maintenance of Source to Pay Orchestration solutions and AI capabilities. This role will partner with business leadership to identify and prioritize opportunities to improve business processes with innovative technology and data, gathering and refining requirements, determining options for solution design, delivering enhancements, supporting integrations, and contributing to technology projects and initiatives. Key Duties and Responsibilities Serve as a trusted advisor for business stakeholders on Source to Pay technology and AI solutions to support...

The Managed Care Contracting Associate Director will provide leadership and management oversight of Market Access Contract processes by facilitating pre- and post-deal analytics, negotiation, and administration of all Payer, Provider, Trade & Distribution, and Hospital Group Purchasing Organization contracts. This person will partner with, among others, Account Management, Finance, Government Pricing & Rebate Operations, GTN, Legal, Marketing, Payer Marketing, Trade Strategy and Accounts to ensure appropriate identification and evaluation of contracting opportunities. These responsibilities will apply across all Vertex marketed product lines and pipeline products. Key Duties and Responsibilities Manage the end-to-end contract (Payer, Provider, Trade & Distribution, Hospital Group...

The Associate Director, FP&A is a leader in Vertex's finance business partnering organization, providing financial direction and strategic insight to the key functional leaders. This role will help define and deliver against short term and long term goals, including identification of key value drivers and Business KPIs and provide strategic decision support, influencing decisions and identifying opportunities to invest, save costs and mitigate risks on a global basis. Key Duties and Responsibilities Provides financial direction and strategic insight to the functional leaders. Helps to define and deliver against short term and long term goals, including identification of key value drivers...

The Project Management & Strategic Operations Director serves as the end-to-end program lead for large-scale strategic programs of high business value within Global Regulatory Affairs (GRA). Drives benefit achievement by leading program initiation, planning, solution design and build, and by measuring key performance indicators and solution adoption. Engages other colleagues/resources and assigns appropriate responsibilities to support achievement of program roadmap and project plan(s). Independently applies expert knowledge of advanced methodologies, selecting and applying high-level project management tools to conduct analyses, reporting and related activities for assigned projects. Contributes to the development of internal protocols and processes used to carry out...

The Associate Director, FP&A is a leader in Vertex's finance business partnering organization, providing financial direction and strategic insight to the key functional leaders. This role will help define and deliver against short term and long term goals, including identification of key value drivers and Business KPIs and provide strategic decision support, influencing decisions and identifying opportunities to invest, save costs and mitigate risks on a global basis. Key Duties and Responsibilities Provides financial direction and strategic insight to the functional leaders. Helps to define and deliver against short term and long term goals, including identification of key value drivers...

We are seeking a highly skilled and visionary Principal Engineer, AI Authoring to join our AI Authoring Platform team. Reporting to the Director of AI Authoring Platform, you will lead the design, development, and optimization of Vertex’s AI-driven content generation engine. This role is pivotal in shaping the technical architecture of our platform, ensuring the performance, accuracy, and scalability of our LLM-powered authoring tools. You will tackle complex engineering challenges, including automated document workflows and Retrieval-Augmented Generation (RAG)-based architectures, to support the creation of high-quality, compliant, and efficient regulatory documents. Key Duties and Responsibilities Design and maintain the end-to-end technical...

The Director, Global Submission Management (GSM) is responsible for the strategic oversight and execution of a portfolio of global regulatory submissions across development and lifecycle programs. This role will manage submissions for development‑stage, lifecycle, regional, and post‑approval, as well as supporting activities required to enable, maintain, and advance global product registrations. This role ensures routine, regional, and lifecycle submissions are delivered efficiently, compliantly, and predictably in alignment with global regulatory strategies and operational objectives. This role partners closely with Major Submission Leads, Global Regulatory Strategy, Regulatory CMC, Labeling, Publishing, and Advertising & Promotion functions to support coordinated submission planning, execution...

Director, Business Engagement & Technology – Commercial Cell and Gene Therapy Location Hybrid or On-site Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. We focus on specialty markets where we have deep expertise in science, technology, and patient needs. At Vertex, our Data, Technology & Engineering (DTE) organization plays a critical role in accelerating business performance, enabling digital and AI transformation, and delivering scalable platforms that support innovation across the enterprise. Role Summary The Director of Business Engagement & Technology will serve as the strategic technology...

The Associate Director, Global Submission Management (GSM) is responsible for the strategic oversight and execution of a portfolio of global regulatory submissions across development and lifecycle programs. This role will manage submissions for development‑stage, lifecycle, regional, and post‑approval, as well as supporting activities required to enable, maintain, and advance global product registrations. The disease area focus of this role will be Pulmonary or Cell & Gene Therapy. This role ensures routine, regional, and lifecycle submissions are delivered efficiently, compliantly, and predictably in alignment with global regulatory strategies and operational objectives. This role partners closely with Major Submission Leads, Global Regulatory...

At Vertex, we invest in scientific innovation to create transformative medicines for people with serious diseases. Our growing Molecular Profiling team is seeking a Senior Scientist, Spatial Transcriptomics to provide scientific and deep technical expertise in spatial biology to support discovery, translational, and development programs. This role will be instrumental in driving mechanistic insights into disease biology, tissue microenvironments, and therapeutic response through spatial profiling of gene expression in tissue context. The ideal candidate will bring deep expertise in spatial transcriptomics, tissue-based molecular profiling, experimental design, and data interpretation, along with strong cross-functional collaboration skills and a passion for technical...

At Vertex, we invest in scientific innovation to create transformative medicines for people with serious diseases. Our growing Molecular Profiling team is seeking a Senior Scientist, Flow Cytometry to provide deep technical expertise in flow cytometry and cellular profiling to support discovery, translational, and development programs. This role will lead and drive the generation of high-dimensional insights into cell phenotype, function, and biology that help inform mechanism of action, biomarker strategies, patient stratification, and program decision-making. The successful candidate will independently own cytometry workstreams across multiple programs and contribute to the scientific direction of molecular profiling efforts. The ideal candidate...

At Vertex, we are relentless in our pursuit of transformative solutions for patients with serious diseases. Our innovative approach to research and development has positioned us as a leader in the biotechnology industry. We are seeking a highly motivated and innovative Senior Scientist, Single-Cell Genomics to join a multidisciplinary research team focused on advancing the understanding of human disease biology and enabling translational research through state-of-the-art cellular and molecular profiling approaches. The successful candidate will lead the design, execution, optimization, and interpretation of single-cell genomics and multi-omics workflows, with a primary emphasis on wet-lab experimental biology. This role will focus...

The Associate Director of Internal Audit will support the development and execution of a risk-based audit plan to evaluate and improve the effectiveness of Vertex’s risk management, control, and governance processes. Reporting to the VP, Chief Audit Executive (CAE), this role will assist in implementing departmental strategy, contributing to annual functional goals, and overseeing portions of the SOX testing program. Key Duties and Responsibilities Maintain strong knowledge of Vertex’s core business and assist in developing a risk and control assurance program aligned with company objectives and risk appetite. Contribute to the development of departmental strategy, Audit Committee reporting, and departmental...

We’re seeking a strategic and hands-on HR Business Partner Senior Director to support our growing commercial organization for our Cell, Gene, Therapy (CGT) & Cystic Fibrosis (CF) portfolio during an exciting period of expansion and innovation. This role will work in partnership with the CGT Vice President and their leadership teams. This new role will support teams during a period of growth, new product launches, and the continued evolution of legacy brands. The HRBP will drive talent strategies that enable business success, foster a high-performance culture, and support organizational agility in a fast-paced environment. This individual will report to the...

JOB TITLE Process Engineering Senior Specialist LOCATION 50 Norther Ave., Boston, Massachusetts 02210 OPENINGS 1 DUTIES Develop & deploy data analytics solutions across manufacturing platforms and products at Vertex and at partner organizations. Enable the development of novel analytical capabilities, by providing frameworks for the high-level approach and establishing robust processes for technical and statistical implementation. Collaborate with internal and external stakeholders to ensure the approach is tailored to the specific business needs and question . Work closely with process and PAT engineers in MS&T to develop multivariate data analyses, machine learning models, mechanistic models, and simulations...

JOB TITLE Facilities Engineering Manager LOCATION 50 Northern Ave., Boston, Massachusetts 02210 OPENINGS 1 DUTIES Lead engineering efforts across clean utilities, equipment, and infrastructure for multiple sites and functions, spanning all project phases including conceptual design, detailed design, construction, startup, commissioning, validation, and ongoing operations. Facilitate and perform design and technical reviews for complex, regulated capital projects with emphasis on efficiency, compliance, sustainability, and cost-effectiveness. Drive multi-site engineering standardization by authoring specifications, design guidelines, and policies that serve as benchmarks for capital projects and operations. Manage cross-functional teams including in-house staff, scientific partners, and seasonal consultants...

JOB TITLE Process Dev Engineering Principal Scientific Associate LOCATION 50 Northern Avenue, Boston, Massachusetts 02210 OPENINGS 1 DUTIES Support the development of robust, scaled upstream or downstream production processes and methods for cell and gene therapy projects. Perform stem cell expansion and differentiation in bench-scale bioreactors to support media development and optimization using high-throughput bench scale systems (Ambr15/Ambr250). Development and documentation of protocols and technologies in support of upstream and downstream cell product development from clinical to commercial scale. Apply DoE/ QbD principles in process development and characterization, establishing process parameters, and contributing to CMC sections of...

JOB TITLE Financial Planning & Analysis Associate Director LOCATION 50 Northern Ave ., Boston, Massachusetts, 02210 OPENINGS 1 DUTIES Provide financial direction and strategic insight to functional leaders, defining and delivering short term and long-term goals, including identification of key value drivers and Business KPIs. Provide strategic decision support, influencing decisions and identifying opportunities to invest, save costs, and mitigate risks on a global basis. Lead financial planning process for areas of responsibility including budget, forecast, and long-range plan to provide meaningful forward-looking direction, to develop key scenarios, and to identify key risks and uncertainties, planning for...

JOB TITLE Director, Information Systems Management LOCATION 50 Northern Ave. , Boston, Massachusetts, 02210 OPENINGS 1 DUTIES Provides strategic quality oversight across GxP computer systems and strategic direction to management of QA-owned systems in support of effective deployment of the Quality Management System (QMS). Coordinating strategic direction and leadership in delivery of operational support, consultation and oversight in assuring adherence with regulatory requirements for computer systems across GxP regulated environments, and adequacy of systems controls for assuring data integrity, and in support of excellence in quality. Driving strategic direction and oversight in the execution of QISM information...

The Regulatory Labeling Director will lead the strategic development of global labeling on one or more marketed products . This role will be responsible for the development and maintenance of global product labeling across a therapeutic area. This will include target labeling profiles (TLP), company core datasheets (CCDS) and local labeling (prescribing information, patient information) for major markets. This role will be accountable for specific labeling business processes. Key Duties and Responsibilities Ensures compliance with labeling governance requirements and associated business processes. Leads label working groups (LWG) and represents labeling at product-specific global regulatory teams and senior labeling governance meetings...

The Director, Regulatory Data is responsible for leading the strategy, governance, execution, and continuous improvement of regulatory data management within Vertex’s Regulatory Information Management System (RIMS). This role provides leadership for the accurate collection, maintenance, quality oversight, reporting, and inspection readiness of critical regulatory data and documentation. The Director leads and develops a team responsible for regulatory data stewardship, establishes scalable processes and standards, and partners cross-functionally to ensure regulatory information is complete, reliable, inspection-ready, and positioned to support portfolio, operational, and compliance decision-making. Key Duties and Responsibilities Lead the Regulatory Data Management function, setting the vision, operating model, priorities,...

The Patient Support Communications Associate Director, Kidney will be responsible for the development and execution of patient and HCP-focused materials that will support our build out of our kidney franchise patient support program focused on AMKD. A deep passion and curiosity in understanding and supporting the challenges patients face in their lives is imperative. You must be an individual who also embraces supporting patients in underserved and diverse patient populations. General/ The Patient Support Communications Associate Director, Kidney is part of the PSP Marketing team and participates in the day-to-day execution of the patient communications strategy . This individual will...

Vertex is a global biotechnology company that invests in scientific innovation. The Digital, Technology and Engineering (DTE) Research, Pre-Clinical, Manufacturing & Supply (RPMS) Group’s mission is to improve the lives of patients through digital, data, and technology innovation. Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our scientific mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. We are seeking a dynamic and experienced Director of Solutions Architecture to join our team and drive our digital transformation initiatives. The Director, Solutions...

The Director, Global Patient Safety Individual Case Safety Report (ICSR) oversees global ICSR processing and external PV partners and vendors. This position manages the technical aspects of end-to-end safety case intake, processing, quality control, and regulatory submissions within a therapeutic area (as assigned) covering the applicable drug, biologic, medical device, and combination products, ensuring operations are consistent, compliant, and inspection-ready worldwide. The Director, Global Patient Safety Individual Case Safety Report (ICSR) plays a key role in global ICSR processing excellence and external business management. This position serves as a subject matter expert in pharmacovigilance (PV) and contributes to developing and...

Vertex’s Data, Technology and Engineering (DTE) organization is seeking a Technology Portfolio Management Director to join our Project Management and Strategic Operations (PMSO) team. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Director, Information Security Technology Portfolio Management will report to our Senior Director of Project Management and Strategic Operations and partner directly with our Chief Information Security Officer to oversee the Information Security project portfolio of new technology implementations. The role requires portfolio planning, financial...

General/ The Director of Analytical Product Quality, is responsible for the quality oversight of analytical development activities throughout the product development lifecycle for Cell & Genetic therapy programs. This role includes Quality Assurance support to cross-functional partners for the method validation of applicable analytical methods and support on analytical transfer activities to contract manufacturers, test labs and internal laboratories as applicable. The role will closely partner with operational stakeholders to participate in Cell & Genetic therapies projects to meet business, regulatory and operational requirements. Key Duties & Responsibilities Proactively maintain Quality Assurance oversight of the method development, and qualification activities...

The Kidney Territory Account Manager (KTAM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs), developing a strategic business plan, communicating thorough disease and product knowledge to HCPs and centers of care. This role must understand market dynamics in rare, complex disease states, demonstrate excellent judgment, and be motivated by the desire to improve patients' lives. The KTAM will report into a Regional Field Leader (RFL) and is responsible for leading engagement with nephrologists and serving as an account manager for specialty kidney clinics. Key Duties and Responsibilities Establishes meaningful and professional relationships with nephrologists and related...

The Patient Safety Associate Medical Director will provide medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development). This role will optimizes patient safety of Vertex products and maintenance of compliance with the Pharmacovigilance regulations of Regulatory Agencies around the globe, through the effective and timely completion of Safety activities through the product life cycle. Key Duties and Responsibilities Provides medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development) Responsible for the safety assessment activities of assigned products under the supervision...

Vertex is a global biotechnology company that invests in scientific innovation. The Data, Technology and Engineering (DTE) Research, Pre-Clinical, Manufacturing and Supply (RPMS) group’s mission is to improve the lives of patients through digital, data, and technology innovation. Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our scientific mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. We are seeking a dynamic and experienced Associate Director of Laboratory Engineering and Technology Site Lead West Coast (LE&W) to join our team and...

The Associate Director, GxP Operations Support Lab Systems will be responsible for supporting documentation and electronic systems related to manufacturing and quality control at the Vertex Manufacturing Center (VMC). This includes overseeing the writing and editing of SOPs, WIs, batch records, training content, and other related documentation, batch record and analytical data review, quality event ownership, and support of MES, LIMS, Tulip, and electronic training. This position also includes group supervision and management. Key Duties and Responsibilities Management and ownership of deviation, CAPA and Effectiveness Check (EC) and Change Control (CC) records in electronic Quality Management System (eQMS) Identify and...

Vertex Pharmaceuticals is seeking to hire a Patient Educator Senior Manager - WEST to join our growing team. The ideal candidate will reside in one of these metropolitan areas Los Angeles or San Francisco metro areas. This is a field based role and candidates must currently reside in the Western Region of the United States. This Patient Educator will report to the Director, Patient Educators and is responsible for providing people living and affected by sickle cell disease (SCD) and beta thalassemia (BT) with education, tools, and resources that help them have meaningful discussions with their healthcare providers. This team...