Vertex Job Trends

At Vertex, we’re driven by a shared purpose to transform the lives of patients with serious diseases. The Executive Director, MSAT will provide strategic and hands-on leadership for Manufacturing Science & Technology (MSAT) across our Type 1 Diabetes cell therapy manufacturing network. This role is accountable for process performance, technical transfer, validation, continued process verification, comparability, and lifecycle management —with a particular focus on external manufacturing partners (CMOs) . You will build and lead a high-performing MSAT organization that bridges Process Development and GMP Manufacturing, ensuring processes are robust, scalable, compliant, and inspection-ready from early clinical supply through commercialization. This...

At Vertex, we are driven by a shared commitment to transform the lives of patients with serious diseases. The Executive Director, Manufacturing Operations will play a critical leadership role in delivering on this mission by building and leading a global external manufacturing network for our Type 1 Diabetes cell therapy programs. This role is accountable for the strategy, governance, and operational oversight of Contract Manufacturing Organizations (CMOs). The leader will operate as a strategic partner to these organizations, ensuring the highest standards of quality, reliability, and scalability to support clinical development and commercialization. Key Duties and Responsibilities External Manufacturing Strategy...

The Senior Administrative Assistant provides high-level administrative and operational support to leaders within Commercial Manufacturing & Technical Operations (CMTO). The role enables efficient execution of CMTO priorities by managing complex logistics, supporting cross-functional coordination, and ensuring seamless day-to-day operations. This position plays a critical role in enabling leadership effectiveness, driving organizational alignment, and supporting key business priorities across CMTO. Key Duties and Responsibilities Manages complex calendars for CMTO leaders, including prioritization of meetings aligned to business criticality across manufacturing, supply chain, and technical operations Coordinates internal and external meetings, including governance forums, offsites, and cross-functional sessions; manages logistics, materials, and...

The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization. This role determines, plans, and executes technically challenging analyses by using state of the art Modeling & Simulation methodologies to strongly contribute to critical decision making. Key Duties and Responsibilities As Modeling & Simulations (M&S) lead in one or more cross functional drug development teams, responsibilities include the development and execution of Modeling & Simulation plans and analyses fully...

The Strategy & Operations Associate Director is a strategic leadership role responsible for translating enterprise and disease area strategies into Cell & Genetic Therapy (CGT) Research-specific execution plans. This role facilitates leadership decision-making and serves as the bridge between Leiden Campus (LC) Research and critical cross-functional partnerships. Bringing a strong combination of scientific and business acumen, the Associate Director advances multiple cross-functional strategic initiatives across Leiden Campus and Cell & Genetic Therapy (CGT) Research. Partnering closely with senior leaders within and outside LC Research, the role helps shape strategic direction, secure alignment, and drive execution against shared goals and priorities....

General/ Vertex is in an exciting time of growth and innovation, and technology and data are valued as strategic assets for the organization. The North America Commercial Operations CRM Field Operations Team is looking for an Associate Director, CRM Field Operations to ensure continued customer centricity and success. The Associate Director, CRM Field Operations plays a critical role between the cross-section of sales and marketing and a close partnership with other business functions. The primary responsibility of this position will be to support designated BU HQ and Field teams with the continuous improvement of the customer relationship management (CRM) system....

The Senior Manager, FP&A is a key member of Vertex’s Finance Business Partnering organization, providing financial leadership and strategic support to the U.S. Kidney team. As Vertex advances toward commercialization of its Kidney portfolio, this role will help shape and deliver near-term and long-term financial goals. This position will play a critical role in supporting pre-launch and post-launch resource allocation in the U.S., a priority market for the Kidney portfolio. The Senior Manager will partner across Finance, Marketing, Sales, Patient Support, Market Access, and other supporting functions to deliver actionable insights, inform decision-making, and help define the key performance indicators...

We are seeking a strategic, influential Senior Director, HR Business Partner to lead the people strategy for Vertex’s Data, Technology & AI (DTE) organization. This role partners closely with the Chief Digital & Information Officer (CDIO) and leadership team to translate business and technology priorities into an integrated talent and organizational agenda . The position plays a critical role in enabling execution of the Data/Technology/AI roadmap through leadership capability, operating model evolution, and enterprise talent strategy. Key Duties & Responsibilities Strategic HR Partner Serve as the primary HR partner to the CDIO and DTE leadership team, translating strategy into prioritized...

Biostatistics Associate Director will perform sophisticated scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with minimal guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent is capable of independent strategic and technical contributions. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Conducts all scientific and operational statistical work for multiple clinical trials, observational studies, or real world data (RWD) investigations....

The International Pharmacovigilance (PV) Specialist is responsible for supporting management of the GPS International PV structure. The International PV Specialist works with a moderate level of supervision and helps troubleshoot problems and improve internal procedures, to ensure compliance with applicable regulatory requirements. Key Duties and Responsibilities Assists with ensuring that all GPS procedures are compliant with global PV regulations Contributes to vendor oversight activities Supports the oversight of local Qualified Persons for Pharmacovigilance (QPPVs) Researches PV regulations and guidelines Reviews, assesses, and tracks global PV regulatory intelligence Reviews PV agreements which support local and regional PV requirements Works cross-functionally to...

The Sr. Quality Manager is an advanced technical resource in the principles and application of quality assurance and compliance. The Sr. Quality Manager coordinates or executes activities on multiple complex projects and takes a role in the design and execution of new projects. Key Duties and Responsibilities Collaborate with internally and external business partners to resolve complex quality issues to ensure compliant solutions Participates in cross-functional teams as an experienced Quality technical resource Drafts and enforces Quality Agreements between CMOs/Suppliers and Vertex, as needed Assists Change Control owners with ensuring compliance to change procedure requirements Assesses and approves change controls...

Vertex is seeking an Analytics & Insights Manager to join the Supply Chain Operations, Resilience, and Efficiency (SCORE) team. This role will partner with supply chain stakeholders across all disease areas to understand reporting needs, define meaningful metrics, and deliver scalable reports and dashboards that support effective decision-making and improve business performance. The individual will work cross-functionally with Finance, ExM, Quality, DTE (Data & Tech), BAR, and other business partners to align on KPIs, reporting definitions, data sources, and analytics priorities. KEY RESPONSIBILITIES Lead supply chain reporting and analytics initiatives from requirements gathering through implementation, adoption, and continuous improvement. Contribute...

The Trade and Distribution Operations Manager is responsible for supporting key trade operations activities across product returns, distribution management, regulatory request processing, and quality documentation. This role partners cross-functionally with Revenue Accounting, Government Pricing, Trade Account Management, Quality, and external distribution partners to ensure compliant, efficient, and accurate execution of trade and distribution processes. The ideal candidate will bring strong operational expertise within the pharmaceutical or biotechnology industry, with experience managing third-party logistics providers, supporting regulated distribution processes, and driving cross-functional resolution of trade-related issues. This role is expected to operate in an on-site or hybrid work model. Key Duties...

The Senior Manager (SM) of Customer Master Data Management reports to the Director of Customer Master & Commercial Data Management in the Commercial Innovation Analytics Operations (CIAO) organization. This individual supports the Global Healthcare Entity Master system (GHEM) and will help drive the customer mastering process, working with a team of data stewards, and supporting overall data governance at Vertex. The ideal candidate is passionate about data, has experience managing data quality and master data initiatives, and understands MDM’s role in enabling and building a 360⁰ view of customers in an enterprise. Key Duties and Responsibilities Support the overall global...

The Kidney Territory Account Manager (KTAM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs), developing a strategic business plan, communicating thorough disease and product knowledge to HCPs and centers of care. This role must understand market dynamics in rare, complex disease states, demonstrate excellent judgment, and be motivated by the desire to improve patients' lives. The KTAM will report into a Regional Field Leader (RFL) and is responsible for leading engagement with nephrologists and serving as an account manager for specialty kidney clinics. Key Duties and Responsibilities Establishes meaningful and professional relationships with nephrologists and related...

The Senior Director, Global Quality Systems holds a pivotal leadership position within the Quality organization. This individual is responsible for providing strategic vision and direction to advance the framework, strengthen organizational capabilities, and ensure the sustainability and effectiveness of the Quality Management System. The role is instrumental in promoting leading practices and supporting the organization's growth as well as adapting to industry changes. This leader provides strategic leadership and oversight across all aspects of Global Quality Systems. This includes guaranteeing the integrity and effectiveness of the framework, enhancing capabilities, and ensuring robust execution throughout GxP domains, various products, modalities, and...

The Senior Manager of Cold Chain Logistics Process is responsible for leading the development and implementation of processes and procedures to ensure the success of cold chain logistics operations within Vertex Pharmaceuticals. This position requires close collaboration with logistics service providers, order management teams, quality assurance, packaging engineering, and other stakeholders to ensure adherence to regulatory guidelines and meet business needs. The Senior Manager will be an integral member of the logistics team, working to develop a robust logistics network to support pipeline programs, evaluate and launch logistics and supply chain information systems, and manage all quality systems from open...

Vertex is seeking a talented leader to join our US Pain Business Unit to support our journey to bring forth new options for the treatment of pain. The Senior Director, US Pain HCP Marketing will lead HCP marketing team for the US Pain Business Unit alongside a team of direct reports, which is launching JOURNAVX, a novel selective pain signal inhibitor of NaV1.8 in acute pain. This role will drive the evolution and implementation of our HCP marketing strategy , supporting the launch through a lean in person presence supplemented by robust digital engagement. This individual will develop/refine the HCP...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The MSAT Senior Scientist (Investigations and Strategic Projects) is responsible for leading complex technical investigations, driving strategic process improvements, and fostering a culture of continuous improvement within manufacturing operations. This role will leverage Six Sigma methodologies, including DMAIC, and lead complex technical investigations utilizing statistical methods and multivariate analysis to understand and identify contributing factors influencing manufacturing outcomes. In addition, this position will drive strategic improvement initiatives across manufacturing operations as a form of continuous improvement. The incumbent will collaborate cross-functionally with Quality, Engineering, Manufacturing, Process Development and Regulatory teams to ensure robust root cause analysis (RCA), effective corrective and...

Vertex is seeking a strategic and collaborative leader to join the US Pain Business Unit to support our journey to bring forth new options for the treatment of pain. The Director, Key Thought Leader (KTL) Strategy & Professional Organizations will play a critical role in shaping and executing Vertex’s engagement strategy with key thought leaders and professional organizations to support the continued launch and growth of JOURNAVX, a novel selective pain signal inhibitor of NaV1.8 in acute pain. This role will be responsible for building and leading a comprehensive KTL engagement strategy, strengthening partnerships with professional societies, and advancing initiatives...

The Facilities Operations Technician performs daily work supporting building operations and maintenance (plumbing, electrical, carpentry, HVAC). This role is expected to monitor the building management system software, and triage and respond to incidents and alarms, conduct facility walks to identify and correct issues, perform maintenance or repair of facilities equipment, install lab gases and/or connections, support space planning and furniture installations, and all other tasks and duties as assigned with minimal supervision. Professional in appearance and the ability to communicate clearly verbally and in writing. The Facilities Operations Technician performs repairs and maintenance to building equipment, machinery, and prepares or...

The Senior Manager of Global Trade Compliance (GTC) – Technical Compliance will support Vertex commercial, clinical, research supply chains by ensuring the uninterrupted, compliant and efficient movement of product across Vertex’s global drug supply, clinical and research network. This individual has a global remit for building and maintaining the detailed technical compliance processes and governance needed to support the trade operations managers, and for assisting in solving detailed operational questions as needed. Areas of focus will include customs valuation and export controls but will also be responsible for product classification (HTS, ECCN & PGA), country of origin (non-preferential & preferential),...

Lab Solutions is the technology and digital capabilities organization supporting Vertex ’ s laboratory operations across the full research and development spectrum—from early discovery in non- GxP environments to heavily validated test and release laboratories within our manufacturing space. Lab Solutions owns the strategy, implementation, and ongoing support of the digital tools that enable scientists and lab professionals to do their best work. The Experiment Capture vertical within Lab Solutions is responsible for the Electronic Laboratory Notebook (ELN) and experiment data capture platforms that underpin scientific documentation across Vertex. This vertical ensures that data is captured accurately, compliantly, and efficiently—whether...

General / The Director, Business Engagement & Technology, Lab Solutions will lead a global team responsible for the architecture, delivery, security, support, and continuous evolution of enterprise laboratory technology platform s – including laboratory Operational Technology (OT) such as information/cyber security , sensors, and IoT enabled lab environments - across all Vertex labs and manufacturing shop fl o ors . This role serves as a senior technology and business partner, ensuring reliable, compliant, and scalable lab operations while advancing the future of the physical and digital laboratory. Operating within highly regulated GxP and SOX environments, the Director is accountable...

The Senior Director, Portfolio & Program Management is a global role within the Program and Portfolio Management (PPM) organization. The incumbent is responsible for championing cross-functional project management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to lead the application of project management to identify opportunities, shape objectives and drive execution of global strategy for cross-functional drug development teams and portfolio operations initiatives. This role is a key leadership position within PPM, with accountability for the performance and end results of a department/area. Key Duties and Responsibilities Provide...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities. Participates...

We are looking for a highly skilled and experienced Associate Director to lead Procurement Operations and Vendor Management within Vertex's BPO-enabled operating model. In this pivotal role, the Associate Director will serve as the senior governance and relationship lead and is the accountable owner of Procurement Operations service delivery across PR-to-PO processing, Procurement Service Desk, and Vendor Master Data Management for outsourced procurement operations, ensuring the BPO partner delivers against contractual commitments, service targets, and strategic procurement objectives. The ideal candidate is a dynamic leader with deep expertise in end-to-end Procure-to-Pay processes, BPO governance, and continuous improvement. The ability to...

The Alliance Management Executive Director will lead the Alliance Management team in supporting the effective execution of global partnering at Vertex. All alliance managers will report to the Alliance Management Executive Director, who will be responsible for ensuring a consistent Alliance Management user experience across the company and helping to resolve issues across all alliances. In addition, the Alliance Management Executive Director will be a spokesperson for the function within Vertex and be responsible for keeping key stakeholders and senior leaders updated on collaboration status and engaging them in issue resolution and relationship management as appropriate. The Alliance Management Executive...

Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Guided by a commitment to patients, scientific excellence, and operational integrity, Vertex brings together deep expertise, collaboration, and innovation to solve some of the most complex challenges in healthcare. Role Summary Vertex is seeking a Manager, TPRM Workflow & Risk Orchestration to join the Global Sourcing & Procurement organization within the Source-to-Pay (S2P) Center of Excellence . This role is responsible for designing and embedding third-party risk management (TPRM) into the end-to-end S2P lifecycle through workflow orchestration, lifecycle...

We are seeking an experienced and detail-oriented Senior Manager to support Procurement Operations and Vendor Management within Vertex's BPO-enabled operating model. Reporting to the Associate Director, the Senior Manager will play a critical role in overseeing BPO-delivered activities, monitoring performance against SLAs, enforcing procurement policy compliance, and driving continuous improvement across outsourced procurement workflows. This role requires a strong operator with excellent analytical and communication skills, and the ability to collaborate effectively with business stakeholders, Finance, Internal Controls, Category Management, and the external BPO partner. This role also supports operational execution across Procurement Req-to-PO, Service Desk and Vendor Master Data...

The Regulatory Strategy Associate Director will be responsible for overseeing the development of regional or global regulatory strategy for development programs or marketed products. This role will serve as a global regulatory lead, or in some cases a regional regulatory lead, for development and/or commercial product(s) within the Vertex portfolio and contribute to the global regulatory strategy for the assigned program(s). This role requires advanced understanding of regulatory affairs frameworks in the US, Europe, or other international markets, drug development, and related concepts, and the ability to translate this knowledge into effective regulatory planning and strategy development. Key Duties and...

Company Overview Vertex

The Project Management Director serves as the operational backbone of the GCO Digitization Strategy Center of Excellence, responsible for orchestrating the end-to-end portfolio of transformation initiatives across 6 workstreams, 50+ participants, and 10+ functional team transformation roadmaps. This role combines program management, value realization, and executive reporting into a single, high-impact position. The Director partners with GCOLT, DTE, and GCO functional leaders to ensure transformation initiatives are delivered on time, cross-functional dependencies are managed, risks are proactively mitigated, and business value is measured and communicated to leadership. This role is critical to ensuring the COE can scale its impact while...

Company Overview Vertex is a global biotechnology company committed to scientific innovation and improving the lives of people with serious diseases. Through a strong focus on patients, collaboration, and operational excellence, Vertex brings together talented professionals to build scalable, compliant, and efficient business capabilities that support its mission. Role Summary Vertex is seeking a Specialist, Buying Channel Orchestration & Enablement to join the Global Sourcing & Procurement organization within the Source-to-Pay (S2P) Center of Excellence (COE) . The Specialist is responsible for supporting the business owner with the enabling, managing, and optimizing buying channels and intake orchestration across the S2P...

About Vertex At Vertex, we are relentless in our pursuit of transformative medicines to improve the lives of people with serious diseases. Building on a strong foundation of advancing therapies for cystic fibrosis, Vertex continues to expand its leadership across multiple disease areas, including cell and gene therapies, with the goal of delivering meaningful impact for patients worldwide. Our Global Heme Cell and Gene Therapy (CGT) Operations team is at the forefront of innovation, commercial strategy, and operational excellence, driving the evolution of the global, cross-functional, "vein to vein” business process for CASGEVY, the only CRISPR-based autologous gene therapy approved...

Vertex Pharmaceuticals is seeking a highly motivated, dynamic, hands-on, collaborative experienced Senior Scientist to join the Histopathology team within Preclinical Safety Assessment (PSA) located at Boston site. PSA is a global function responsible for the design and conduct of comprehensive nonclinical safety programs at all stages of discovery and development. The Histopathology team supports animal model development and efficacy studies to enable the evaluation of candidate therapeutic agents. Pathobiology Research Scientist will perform routine and specialized histology techniques, wet lab work, data acquisition and compilation using state-of-the-art molecular pathology techniques. The incumbent will interface closely with other scientists, veterinary pathologists...

The Predictive and Investigative Safety Assessment (PISA) group is seeking a candidate with a strong desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families, and society. This role will support preclinical safety assessment across the global research portfolio from target selection through lead optimization. Work within a close-knit team, this individual will leverage advanced in vitro technologies, laboratory automation, and computational approaches to design, execute, analyze, and derive insights from mechanistic and phenotypic screening assays designed to evaluate the safety of new candidate molecules. As an integral part...

The Cost Accounting Senior Manager focuses on accounting, analysis and reporting for inventory movements, reserves, and cost of goods. This is a broad role with duties that relate to cost and inventory accounting valuation analysis and internal controls. The Senior Manager will work closely with various teams across the global organization, including Accounting, Finance, Supply Chain, Commercial, GIS, and R&D Project Teams. Key Duties and Responsibilities Has process oversight of assessing inventory for excess and obsolescence reserves and other key judgements. Works closely with the Supply Chain Team to understand production schedules, contracts, inventory movements and other supply chain matters...

The Pain Medical Affairs Science Senior Director is a critical role in Global Medical Affairs, working on global activities for the Pain disease area. Key responsibilities include, but are not limited to, Medical Plan development, launch strategy and execution, scientific leadership, external medical expert engagement, and strategic alignment with commercial and other cross-functional business partners. This role will also be critical in developing medical content, including training, Q&A, and externally facing medical materials, and contributing to the development of the publication plan. This role reports to the disease area Global Medical Lead and is a core member of the disease...