Vertex Job Trends

The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Vertex's broad Nephrology programs including IgAN and AMKD. The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response...

The Associate Director, Global Trade Compliance (GTC) Business Process Owner (BPO) is responsible to develop and maintain processes and GTC systems that enable compliant, consistent, accurate and efficient filing of customs declarations for all Vertex exports and imports; as well as related GTC activities. The BPO will collaborate with the GTC team on developing overall trade compliance strategy; further shape the strategy into repeatable scalable business processes and systems; functionally own the Global Trade Management (GTM) system and technology including interfaces with Vertex ERPs and other systems to support these processes; and act as a GTC Project Manager for process...

We are seeking an accomplished and strategic leader to serve as Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA), to guide the DMPK-BA strategy for our rapidly growing Biotherapeutics portfolio that includes protein, antibody, ADC, and cell and genetic therapies. The responsibilities will span from early research through development. This leader will be based in Boston but manage and oversee the work of DMPK-BA teams at our Vertex Biologics and Cell and Genetic Therapies sites in Boston and Seattle and will be part of the Global DMPK leadership team. He/she will play a central role in integrating PK, bioanalysis, ADME, and translational PKPD...

The Senior Director, FP&A – Supply Chain serves as the senior finance partner to Vertex’s Head of Global Supply Chain and their organization, providing strategic financial leadership and drives planning and performance management, influencing enterprise‑critical investment and operational decisions. This position guides strategic decision-making across supply chain planning, inventory management, logistics, trade compliance, risk management and business continuity and distribution network optimization. Key Responsibilities Lead Finance Business Partnering Lead finance business partnering for all global supply chain functions – supply chain planning, inventory management, logistics, trade compliance, risk management and business continuity and distribution network optimization – to drive financial...

The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Vertex's broad Nephrology programs including IgAN and AMKD. The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response...

The Clinical Trial Management Principal is responsible for leading global or regional-based activities on complex clinical trials across a range of study phases (Phases 1 through 4, including Real World Evidence trials) and therapeutic areas. In the global role, the Clinical Trial Management Principal leads the global cross-functional Study Team, ensuring that deliverables are met, quality is maintained throughout the lifecycle of the trial, and the study budget is maintained. The role is also responsible for contributing to Clinical Trial Management department initiatives, often as leader. Key Duties and Responsibilities Accountable for execution of assigned clinical trial(s) at the global...

Vertex Pharmaceuticals is seeking a highly motivated, dynamic, hands-on, collaborative experienced Senior Scientist to join the Histopathology team within Preclinical Safety Assessment (PSA) located at Boston site. PSA is a global function responsible for the design and conduct of comprehensive nonclinical safety programs at all stages of discovery and development. The Histopathology team supports animal model development and efficacy studies to enable the evaluation of candidate therapeutic agents. Pathobiology Research Scientist will perform routine and specialized histology techniques, wet lab work, data acquisition and compilation using state-of-the-art molecular pathology techniques. The incumbent will interface closely with other scientists, veterinary pathologists...

Vertex is a global biotechnology company that invests in scientific innovation. The Digital, Technology and Engineering (DTE) Research, Pre-Clinical , Manufacturing & Supply (R P MS) Group’s mission is to improve the lives of patients through digital, data, and technology innovation. Vertex is in a transformational period where we are accelerating our capabilities, technology and data to augment our scientific mission and enable Vertex to grow in scale; ensuring we remain on the forefront of science, medicine and technology. We are seeking a dynamic and experienced Director, Supply Chain Technology to join our team and drive our digital transformation initiatives....

This is a Hybrid position requiring 3 days a week in our Boston office We are seeking an experienced AI engineering leader to build and operate Vertex's Agent Intelligence layer the memory, personas, skills, and flagship agent experiences that make every Vertex AI agent grounded, consistent, and effective. Vertex Pharmaceuticals is in a transformational period, and the AI team is at the center of our AI-first strategy, delivering solutions that empower executives, researchers, and business users to make faster, more confident decisions. As part of the Vertex Data team, you will lead the Agent Intelligence function within Knowledge & Grounding....

The Quality Product Complaints Associate Director is responsible and accountable for providing quality oversight of the Product Complaint Quality System and the Global Recall and Defect Notification Systems. This role will support quality activities associated within the Compliance team and will partner with various internal and external cross-functional teams including Global Patient Safety, Supply Chain/Trade and Distribution, Medical Information, Guidance and Patient Support, Quality Assurance, Contract Manufacturing Organizations, and external Call Centers. The Associate Director also drives continuous improvement in Vertex quality processes and governance to assure Vertex remains adherent to regulatory expectations and supports QA operational quality oversight and...

As a key leader in the Strategic Sourcing function, the Director, Data, Technology & Engineering (DTE) is responsible for enabling enterprise value delivery through the development and execution of global category strategies, strategic supplier partnerships, and advanced commercial outcomes that directly support the company’s digital and AI-driven transformation vision. This role delivers strategic, scalable, and future-ready sourcing solutions across software, cloud, data platforms, AI/ML capabilities, digital engineering, and technology-enabled services, with a focus on accelerating innovation, speed-to-value, and enterprise capability building in support of next-generation data and technology priorities. This leader plays a critical role in shaping and advancing the...

The Principal Scientist/Engineer, Manufacturing Science and Technology (MSAT) – Biologics & Cell Therapy is a key technical role within the Commercial Manufacturing and Technology Operations (CMTO) organization. This position supports late‑stage clinical and commercial programs across the Vertex Biopharmaceutical Sciences and Manufacturing Operations (BSMO) network, with a focus on manufacturing process support, lifecycle management, and technical execution for biologics. Based at the Boston Seaport site, this role partners closely with cross‑functional internal teams and external manufacturing partners to ensure robust, compliant, and scalable manufacturing processes that enable reliable clinical and commercial supply to patients. Key Responsibilities Provide MSAT support across...

Director Marketing, GCS Kidney Vertex is seeking a talented leader to join our Global Commercial Strategy (GCS) team and work on our Autosomal Dominant Polycystic Kidney Disease (ADPKD) pipeline program. ADPKD is a genetic kidney disease characterized by the growth of kidney cysts that ultimately results in kidney failure and premature mortality. The Director GCS will be responsible for developing commercial strategy, generating new market insights, developing and positioning our brand(s), and preparing for launch. This role will report to the GCS Vice President for Kidney Disease, who leads global commercial strategy for all Vertex Kidney programs. The successful candidate...

This is a Hybrid position requiring 3 days a week in our Boston office We are seeking an experienced engineering leader to build and operate Vertex's enterprise Knowledge Graph and Semantic Layer the unified, navigable representation of Vertex's data, concepts, and relationships that AI agents and analytical systems traverse to reason over our business. Vertex Pharmaceuticals is in a transformational period, and the AI team is at the center of our AI-first strategy, delivering AI solutions that empower executives, researchers, and business users to make faster, more confident decisions. As part of the Vertex Data Engineering team, you will lead...

The Associate Director, DMPK and Bioanalysis drives DMPK-related activities across multiple biotherapeutic programs. This role is recognized internally as an emerging leader in one or more disciplines within DMPK, as well as bringing technical expertise in bioanalytical assay development, validation, and CRO management. The Associate Director demonstrates scientific rigor and accountability, working collaboratively across functions and teams to ensure delivery of reliable, high‑quality DMPK and bioanalytical data in support of Research and Development programs. Key Duties and Responsibilities Acts as the DMPK and Bioanalytical Lead on multidisciplinary project teams, representing the integrated DMPK‑BA perspective and clearly communicating data, risk assessments,...

Job Summary Vertex is seeking an experienced Associate Director, Quality Control to provide strategic and operational leadership for commercial Cell and Gene Therapy (CGT) programs supported through external manufacturing and testing partners. This role is accountable for QC oversight of CMOs and CTLs, people leadership within the External Manufacturing QC organization, and sustained inspection readiness for commercial supply. The successful candidate will lead teams responsible for external QC oversight, drive resolution of complex quality and technical issues, and ensure continuous improvement in compliance, efficiency, and performance across the external network. Key Responsibilities Provide strategic QC oversight for commercial CGT external...

The Director, Major Application Submission Management is accountable for the strategic oversight and execution of a defined portfolio of enterprise‑critical, major global regulatory applications across complex development and lifecycle programs. This role leads end‑to‑end submission planning and delivery for high‑impact filings, ensuring submissions are executed efficiently, compliantly, and in alignment with global regulatory and business strategies. This role is scoped to major health authority applications (e.g., NDA, BLA, MAA, and equivalents) where submission outcomes have material regulatory, commercial, and patient‑access implications. The Director serves as a strategic partner to Global Regulatory Strategy, Regulatory CMC, Labeling, Publishing, and Advertising & Promotion...

We are seeking an Analytical and Purification Chemistry Senior Research Scientist to support discovery programs through the development and execution of analytical and purification strategies. This role requires deep expertise in separation science, with a particular focus on chiral purification using analytical and preparative supercritical fluid chromatography (SFC). The successful candidate will play a key role in delivering high-quality purified compounds and analytical data to cross-functional teams, enabling rapid progression of discovery programs. This position is intended for a scientist who can operate with a high degree of technical independence and serve as a subject matter expert in chiral purification...

GENERAL/POSITION SUMMARY The Senior Manager, GMP Inspection Readiness plays a key role in ensuring ongoing inspection readiness across Vertex and our manufacturing network. This individual will lead and enhance real-time GMP inspection readiness activities for Contract Manufacturing Organizations (CMOs) spanning multiple modalities, including Small Molecule, Cell & Gene Therapies, Biologics, and Medical Devices. Responsibilities include developing and managing readiness plans, overseeing key deliverables and metrics, identifying and mitigating risks, and supporting regulatory inspections from the preparation stage through follow-up activities. This role requires strong project management, strategic thinking, and the ability to work effectively across a broad range of stakeholders...

The Director, S2P - Strategy, Governance & Excellence is a critical leadership role responsible for establishing the foundational operating model, governance, and standards for the Source‑to‑Pay (S2P) Center of Excellence. This role serves as the architect, steward, and driver of procurement excellence , ensuring scalable processes, strong governance, digital enablement, and continuous capability advancement across the enterprise. This leader will operate at the intersection of strategy, execution, and influence , partnering closely with Sourcing leadership, Finance, Legal, Sustainability, Digital/IT, and business stakeholders to elevate departments impact and maturity. The role directly supports enterprise value creation through supplier relationship management (SRM),...

The incumbent will work cross-functionally with colleagues in the BSMO/CMSC, Regulatory, Quality and R&D of Vertex on the design of processes and technologies required to produce aseptic and/or low bioburden drug products to successfully commercialize an exciting and diverse portfolio of innovative pipeline programs. In addition, the successful candidate will support the implementation of risk-based design and controls for low bioburden process operations for production of drug substance/intermediates for manufacturing. Key Duties and Responsibilities Provide technical input into environmental/facility/process monitoring program deviations and contamination events to determine impact to batch disposition and design/implement effective corrective and preventative actions to prevent...

As the Field Analytics and Reporting Associate Director , you will be responsible for supporting all field analytics to support the current and upcoming product launches for Vertex. This role reports to the Director of Field Analytics in North America IACO (Insights Analytics & Commercial Operations). This role will support strategy, design, roadmap planning, delivery, and adoption of all analytics across all field roles within the Strategic Customer Engagement Team including Field Account Managers, Regional/Area Managers, Strategic Account Leads, and Virtual Field Representatives. This role will also serve as a critical team member for the Business Unit Analytical Support team...

Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA. The successful candidate will be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates. Excellent leadership, interpersonal, and organization skills as well as a high level of technical aptitude and creativity are required for success in this position. Key Duties and Responsibilities Be responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable,...

The Senior Medical Director will define the clinical development strategy of an asset, work with cross-functional multidisciplinary teams to define overall asset strategy as well as clinical trials strategy, design and execution, and may serve as the Medical Lead for clinical trials that will be conducted with these compounds. Key Duties and Responsibilities Defines a clinical development strategy and prepare the clinical development plans, in conjunction with other relevant functional areas Participates in the development of study protocols, statistical analysis plans, investigator's brochures, and other key study documents in conjunction with other line functions and with minimal guidance Leads the...

The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program. Key Duties and Responsibilities Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and...

Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA to lead the Materials Development Group. The Material Science Senior Director will support Vertex's drug development programs through a specialized depth and breadth of knowledge of various relationships between materials properties, pharmaceutical processing conditions, and final product performance and quality attributes. The successful candidate will have a proven track record of applying specialized knowledge in solid state science and engineering principles and be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the...

Vertex is seeking an experienced commercial leader to lead North America’s Field Operations team. The Senior Director, Field Force Operations will partner with Business Unit leaders and cross-functional stakeholders to enable and support all of North America’s commercial field forces. This role reports to the Executive Director, North America Commercial Operations & Insight Analytics. Key Duties & Responsibilities Develops and implements industry best practices for sales force field enablement for launch and in-line brands Lead a team of field operations personnel and contingent workers Responsible for providing input into the field incentive compensation (IC) design with BU stakeholders. Manage the...

The Associate Director, GMP Operational Quality is responsible for quality oversight of QC data review for both non-routine and routine cGMP process testing and in support of stability testing of Cell & Genetic Therapy products. The role will also oversee team activities, development of personnel and ensuring quality of deliverables within department purview. The incumbent has comprehensive knowledge of principles and application of quality assurance and compliance. The incumbent is responsible for development of group goals and projects ensuring alignment with corporate goals and compliance with all regulatory requirements, refining goals and projects when necessary. The incumbent not only coordinates...

The Customer Engagement Liaison (CEL), is an extension of the marketing team and responsible for identifying and driving engagement with key nephrology stakeholders, primarily healthcare providers (HCPs) in relation to commercial programming such as speaker bureaus, advisory boards, congresses, and regional insights meetings. The CEL supports current/future disease and other potential diseases. Vertex CELs work with key nephrology stakeholders in their assigned territory to collect insights and derive knowledge with an overall goal of informing the development and evolution of the marketing and brand strategy. They will drive advocacy of the disease portfolio with National/Regional Key Opinion Leaders (KOLs) and...

In June 2019, Vertex announced the establishment of new research sites in Boston and Providence where research, development, and clinical manufacturing for cell, biologic, and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several diseases Vertex is focused on. At Vertex, our teams bring together the best talent to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible. The Product Development Engineering Senior Scientist focuses on combination product development, with a particular focus on drug delivery systems. The Product Development Engineering Senior...

In June 2019, Vertex announced the establishment of new research sites in Boston and Providence where research, development, and clinical manufacturing for cell, biologic, and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several diseases Vertex is focused on. At Vertex, our teams bring together the best talent to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible. As the Product Lifecycle Engineering Principal Scientist, you will focus on the sustaining activity with drug delivery devices and combination products. You will ensure...

The Audit Management Associate Director is responsible for the audit and inspection management for assigned activities, inclusive of internal and external processes. This role has responsibility for design and execution of compliance audits primarily across GCP/GLP suppliers and clinical investigator sites through the development of a risk-based audit program designed to support activities across Vertex business functions. This role ensures adherence to applicable regulations, industry standards, and to Vertex policies, procedures, and quality standards as set forth in the Quality Management System. This role may be a generalist but more often specializes in laboratory or clinical practices. Regularly applies specialized...

Vertex Pharmaceuticals is seeking a Pharmacology Research Scientist to join our pain pharmacology group in San Diego. We are looking for a motivated, creative, and innovative scientist with a deep understanding of ion channel physiology and pharmacology and expertise in pain research. This lab-based role involves designing mechanistic studies, developing cellular models of neuronal function, and analyzing data to guide decision-making. Preference will be given to candidates with extensive experience using cutting edge electrophysiological and imaging techniques, utilizing primary cells, including human cells. The successful candidate will demonstrate a strong desire to collaborate within a multidisciplinary drug discovery team. Key...

The Trade and Distribution Operations, Senior Manager is responsible for supporting Trade department operational activities, and the Trade account management team. The qualified candidate will drive Third-Party Logistic provider (3PL’s) programming, support daily business activities, manage returned goods processes and new product launch planning. The incumbent will be a key contributor in the implementation, management, and strategy development for Vertex’s 3PL programs and support commercial contract analytics. This individual will ensure products are available and readily accessible to Specialty Distributors, Wholesalers and Specialty Pharmacy network partners within Good Distribution Practices (GDP). Key Duties and Responsibilities Tactical execution of daily distribution...

The Modeling & Simulations Scientist II-(PKPD Programming) is a primarily hands-on programming leader responsible for delivering high-quality PK/PD, PopPK, and exposure-response analysis datasets, outputs, and regulatory submission deliverables, while advancing process standardization, automation, and quality across Phase 1–3 studies. This role also provides team and operational management through resource planning, mentoring, workload coordination, and oversight of programming activities to ensure timely, compliant, and efficient delivery. By combining technical expertise with people leadership, the position supports Clinical and Quantitative Pharmacology objectives and contributes to the successful execution of the development portfolio. Key Duties and Responsibilities Lead hands-on PK/PD programming deliverables by...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

At Vertex, we are at the forefront of innovation in Cell and Gene Therapy (CGT), transforming lives through groundbreaking treatments. The Salesforce Technical Architecture & Strategy Lead plays a pivotal role in this mission, serving as a cornerstone for our Data, Technology, and Engineering (DTE) team. This role is instrumental in driving the success of the Vertex Connects Portal for CGT systems, which integrates critical capabilities across our Commercial and Supply Chain functions. As a key leader, you will collaborate with cross-functional teams, design and implement cutting-edge solutions, and ensure the seamless operation of our Salesforce platform. Your expertise will...

…………………………………………….. VERTEX PHARMACEUTICALS Data Technology & Engineering (DTE) POSITION DESCRIPTION Title/Role Location Boston, MA The Associate Director, DTE Business Engagement Lead for Real Estate, Facilities and Operations Systems is a technical leadership role responsible for driving the digital transformation of Real Estate, Facilities, and Operations systems across the organization. This technical leader will partner with business stakeholders to define and execute the roadmap for AI-enabled solutions, smart building technologies, workplace systems, and data-driven operational improvements that enhance performance, efficiency, user experience, and compliance. The Associate Director is responsible for the design, development, support, maintenance, and future technical roadmap of...

We are seeking a motivated Scientist to join our Protein Science team. In this role, you will purify and characterize therapeutic proteins and research reagents at milligram- to gram-scale in support of early- and late-stage discovery programs. The ideal candidate will bring strong expertise in protein purification, protein analytics, and protein-protein interaction characterization, and will help advance platform capabilities through innovative approaches in analytical characterization and biologics developability assessment. Key Duties and Responsibilities Operate AKTA chromatography systems using UNICORN software to purify antibodies, Fc fusion proteins, and His-tagged protein reagents for in vitro and in vivo applications. Design and execute...

Vertex’s Data, Technology and Engineering (DTE) organization is seeking a Technology Portfolio Management Director to join our Project Management and Strategic Operations (PMSO) team. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Director, Information Security Technology Portfolio Management will report to our Senior Director of Project Management and Strategic Operations and partner directly with our Chief Information Security Officer to oversee the Information Security project portfolio of new technology implementations. The role requires portfolio planning, financial...

Reporting to the Senior Director, Contract Operations & Deal Assessment, this role is responsible for leading the end-to-end contracting lifecycle, overseeing drafting, negotiation, execution, and compliance to drive revenue and mitigate risk across all franchises. This position will lead the Contract Operations team, develop standardized templates, manage playbooks, and optimize processes in support of the cross functional operations teams, Market Access Strategy, Account Leadership, and Legal. The ideal candidate will be familiar with and highly conversant in various segments of market access, discuss and incorporate contracting strategies and tactics, and understand the various types of managed care and trade contracting....

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

The Discovery Process Chemistry Research Scientist will work as part of the Scale-up group in Medicinal Chemistry to synthesize compounds on a range of scales from multigrams to hundreds of grams for biological evaluation. Performs experimental troubleshooting and synthetic route development with the ability to execute complex experimental procedures. Completes work in a resourceful, self-sufficient and timely manner and is able to design alternative approaches to achieve desired outcomes. Keeps up to date with current scientific literature and technologies relevant to their field of technical expertise. This is an onsite position at our San Diego research site. Key Duties and...

Reporting to the Senior Director, Contract Operations & Deal Assessment, this role is responsible for leading the end-to-end contracting lifecycle, overseeing drafting, negotiation, execution, and compliance to drive revenue and mitigate risk across all franchises. This position will lead the Contract Operations team, develop standardized templates, manage playbooks, and optimize processes in support of the cross functional operations teams, Market Access Strategy, Account Leadership, and Legal. The ideal candidate will be familiar with and highly conversant in various segments of market access, discuss and incorporate contracting strategies and tactics, and understand the various types of managed care and trade contracting....