Vertex Job Trends

Vertex is currently building a case management team to support our upcoming journey to advance, develop, and deliver therapies to those living with serious kidney diseases. We are preparing for potential commercialization of investigational therapeutics being studied for the treatment of Immunoglobulin A nephropathy (IgAN), additional B cell-mediated diseases, as well as other genetic kidney diseases. Vertex is seeking a patient-centric, dedicated, and collaborative case management professional to join its US Kidney Patient Support Program (KPSP). The Patient Support Specialist (PSS) would support KPSP-enrolled patients as a trusted guide along the treatment journey compliantly educating and providing resources to prevent...

Vertex is seeking an Agent Engineer, Agentic AI Platform to help create the next generation of AI agents that deliver practical value across internal and user-facing experiences. This role will focus on prototyping, building, and productionizing multi-step agent workflows that are deeply integrated with enterprise systems, business processes, and digital products. The ideal candidate is energized by fast-moving AI technology but grounded in strong engineering discipline. This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connect agents to APIs and business systems, and continuously improve quality through measurement and...

Vertex is seeking an Integrations Engineer, Agentic AI Platform to connect the AI/agentic platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows. This role will focus on designing and implementing secure, scalable, and reliable integrations across internal platforms, third-party applications, and business-critical services. The ideal candidate brings strong expertise in MCP/A2A protocols, APIs, event-driven architectures, authentication patterns, and enterprise integration design. This individual will play a key role in ensuring AI capabilities are embedded into day-to-day work at Vertex and not as isolated proofs of concept, but as production-ready solutions integrated into the...

The Lab Automation Engineer will be a part of a team dedicated to designing, implementing, and validating automation solutions, across various automation platforms (Hamilton/Biomek/etc.), with a moderate degree of supervision. This role will support multiple disease areas and advance automation capabilities within Vertex Cell & Genetic Therapies. This role will develop an understanding of the research and development processes in order to establish new capabilities and improve efficiencies through automation enhancements. This is an onsite position at our Leiden Center research site in Boston. Key Duties and Responsibilities Translates manual research and development processes into the design of automation systems....

General position summary The Senior Manager, RDQ Learning & Documentation Governance will lead the oversight and coordination of R&D Quality (RDQ) learning governance, documentation governance, and operational readiness activities in partnership across RDQ, with Global Quality Training, Global Documentation, and cross-functional stakeholders. This role will serve as a central coordinator and governance lead for RDQ learning, documentation, and curriculum management activities, ensuring alignment to evolving regulatory expectations, quality systems, inspection readiness priorities, and organizational transformation initiatives. The individual will drive consistency, oversight, and continuous improvement of the RDQ curricula, such as establishing role based training and partner with stakeholders to...

Vertex is seeking a Sr. Principal AI Engineer, Agentic AI Platform to design, build, and optimize the shared platform capabilities that power AI-enabled products and intelligent workflows across the enterprise. This role will focus on delivering production-grade platform services for model integration, prompt and workflow orchestration, evaluation, observability, performance optimization, and agent lifecycle management. A key focus of this role will be enabling a build/bring-your-own-agents capability within the Agentic AI Platform, allowing teams across Vertex to create, integrate, customize, and operationalize their own agents using shared platform standards, tooling, and governance controls. The ideal candidate combines strong software engineering fundamentals...

Principal Engineer, VaiDA User Experience Location Hybrid / On-site Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. At Vertex, we combine cutting-edge science, technology, and human-centered thinking to solve complex challenges and improve lives. Our digital and AI initiatives help empower employees across the organization with scalable, intuitive tools that accelerate innovation and decision-making. Role Summary Vertex Pharmaceuticals is seeking a Principal User Experience Engineer to shape the future of VaiDA, our enterprise AI platform for employees across Vertex. This role will design and build polished, seamless...

The Business Engagement & Technology Principal Analyst will be a technical resource in ensuring delivery and support of commercial-off-the-shelf (COTS) and a wide range of custom solutions in support of their business partners. The Business Engagement & Technology Principal Analyst will partner with business leadership to deliver capabilities and execute on a roadmap that align to support business strategy . Additionally, the Business Engagement & Technology Principal Analyst will maintain reliable, scalable and compliant systems that easily meet business needs by efficient delivery and enhancements that provides opportunities for developing and implementing innovative solutions and integrations. Key Duties and Responsibilities...

Vertex is seeking a Sr. Principal AI Engineer, Agentic AI Platform & Control Tower Ops to define and build the foundational enterprise AI platform that powers intelligent applications across the enterprise. This role will lead the design and implementation of scalable, secure, and reusable capabilities for agentic AI, with a strong focus on retrieval-augmented generation (RAG), orchestration frameworks, evaluation systems, and platform architecture. In addition to building out the core platform, this leader will own the vision for a centralized AI Control Tower / Control Plane / Gateway that enables agent monitoring, observability, policy enforcement, governance, and operational controls across...

Why Join Us? Vertex is a transformative biotechnology company that creates new possibilities in medicine to transform diseases and improve people’s lives. The company currently has five drugs on the market that treat the underlying cause of cystic fibrosis, one therapy on the market that is a cell and gene therapy treatment for sickle-cell disease and transfusion-dependent t β-thalassemia, and one drug on the market for the treatment of acute pain. It has also developed a deep pipeline, investing billions of dollars into R&D over the past two decades. Vertex is seeking an experienced Legal and Compliance professional to join...

The Business Engagement & Technology Associate Director will be a key technical resource in ensuring the planning and delivery of key commercial-off-the-shelf (COTS) and a wide range of custom solutions in support of their business partners. The incumbent will partner with business leadership to develop capabilities and systems roadmaps that align to support business strategy. Additionally, the Business Engagement & Technology Associate Director will ensure team members maintain reliable, scalable and compliant systems that easily meet business needs by efficient delivery and enhancements that provides opportunities for developing and implementing innovative solutions and integrations. Key Duties and Responsibilities Become a...

Vertex is seeking an Agent Engineer, Agentic AI Platform to help create the next generation of AI agents that deliver practical value across internal and user-facing experiences. This role will focus on prototyping, building, and productionizing multi-step agent workflows that are deeply integrated with enterprise systems, business processes, and digital products. The ideal candidate is energized by fast-moving AI technology but grounded in strong engineering discipline. This individual will use a forward deployed engineering mindset to work closely with stakeholders, rapidly iterate on real-world use cases, connect agents to APIs and business systems, and continuously improve quality through measurement and...

Vertex is entering a transformative phase in its data journey—where trusted, governed master data is foundational to enabling enterprise-wide analytics, AI, and operational excellence. We are seeking an execution-focused Associate Director, Customer Master to lead the Customer(HCP/HCO) master data domain within Vertex’s Enterprise Master Data Management (MDM) organization reporting to the Director, Enterprise MDM. This role will be responsible for one of the most critical and complex data domains at Vertex. The Global Healthcare Entity Master (GHEM) supports a broad range of cross-functional processes and is foundational to commercial operations, analytics, and decision-making. This role will provide end-to-end ownership of...

Vertex is seeking a Principal Analyst, G&A Technology to support our Legal, OBIE , and Corporate Communications functions. In this role, you will partner closely with stakeholders to deliver technology solutions that strengthen operations, enhance the user experience, and support strategic priorities across corporate functions, with a particular focus on Legal, Compliance and Corporate Communication needs. The ideal candidate combines deep expertise in technology delivery, stakeholder engagement, and cross-functional leadership with a proven track record of partnering with Legal, Compliance, and Corporate Communications organizations in complex, highly regulated environments. This person will translate business needs into scalable technology solutions, lead...

Job Summary Vertex is seeking a Director, Field Effectiveness to understand, analyze, and build solutions to maximize field effectiveness and drive commercial performance. This leader will play a critical role in shaping and advancing field effectiveness strategies, with a focus on targeting effectiveness, incentive design, account planning, and field force performance optimization . The Director will serve as a key thought partner to the sales and business unit leadership, field team leaders, I&A partners, and other cross-functional stakeholders to ensure field teams are equipped with the insights, tools, and performance frameworks needed to execute with impact. This role requires a...

The Chemistry Manufacturing Controls (CMC) Associate Director leads and executes global regulatory CMC strategies across investigational and commercial products focusing on biologics. This role is accountable for authoring, reviewing, and delivering high-quality regulatory submissions, while serving as the primary CMC interface with Health Authorities. The role integrates advanced digital and AI-enabled approaches to enhance the quality, consistency, and efficiency of regulatory document preparation and review. Key Duties and Responsibilities Leads preparation, review, and lifecycle management of CMC sections of global regulatory submissions for biologics (INDs/CTAs, NDAs/BLAs/MAAs) Develops and drives global CMC regulatory strategies for assigned programs Serves as primary regulatory...

The Patient Safety Epidemiology Associate Director leads safety and regulatory epidemiology activities for Vertex products across multiple therapeutic areas and throughout all phases of lifecycle. This includes execution of post-marketing regulatory study research strategies, leading comprehensive epidemiologic feasibility assessments, development of epidemiologic study designs, overseeing study implementation, interpretation of findings and communication to internal and external audiences. Key Duties and Responsibilities Major contributor and driver to the company safety risk management, signal detection, benefit/risk assessments, and post-marketing regulatory research strategies Expected to research the epidemiology of specific disease areas and events of interest, lead evaluation of data sources and data...

Vertex Patient Support (VPS) is seeking an experienced and highly motivated Associate Director, Assurance (AD, Assurance) to serve as a key leader within the US Patient Support Center of Excellence (COE) Program Quality team. Reporting to the Director of Program Quality, the AD provides operational leadership for the execution of the assurance program across Cystic Fibrosis, Kidney, and Hematology Patient Support Programs (PSPs) supporting both GxP and non-GxP functions. The Associate Director will provide oversight for the execution of quality assurance activities, including internal audits and continuous monitoring, corrective and preventive action (CAPA) management, and quality reporting. In collaboration with...

Overview At Vertex, the People Advisor delivers high-impact, manager-facing HR advisory support that helps leaders make effective people decisions, strengthen organizational health, and create a consistently positive employee experience. This role supports the Corporate Functions portfolio and will partner closely with managers through everyday people decisions, moments of change, and critical workforce cycles. Operating within Vertex’s HR service-based model, the People Advisor focuses on proactive coaching, early intervention, talent planning, program enablement, and people insights while partnering with People Experience, Employee Relations, HR Business Partners, HR Operations, and Centers of Excellence to route transactional, programmatic, or formal investigative work to...

Vertex is entering an exciting phase of commercial diversification. As we expand into new pipeline disease areas and new geographies, we are investing in data, technology, and AI to scale commercial operations globally. The Commercial, Medical and External Affairs Technology team is expanding our capabilities with increased investment in data, platforms, and AI. This role establishes the end-to-end architecture required to scale AI and digital capabilities across the enterprise. The Senior Director, Commercialization Technology Architect is responsible for defining and governing target-state architectures, integration patterns, and platform standards that enable scalable, secure, and compliant AI solutions. This role ensures technologies...

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities. Participates...

As the Strategic Sourcing Manufacturing & Supply Director for Small Molecules, you will be part of a fast-growing, innovative organization at the company’s world headquarters in Boston, MA. The department is committed to a trusting and collaborative culture where growth and development are valued. We engage proactively with stakeholders to understand their needs and deliver results for our company and for patients. If you are looking for an entrepreneurial, hands-on, team-oriented environment where you can make a meaningful impact, this is the right place for you. This is a key leadership role focused primarily on materials and services that support...

The Senior Director, Finance Integration Lead will serve as the finance business partner for M&A activities. This role is critical to enabling a disciplined, well-governed integration that supports business continuity, financial transparency, strong controls, and alignment with Vertex standards. This role will oversee the financial strategy, execution, and outcomes of M&A integrations, ensuring that cross-functional value capture assumptions, financial considerations, and integration-related commitments are clearly baselined, tracked, governed, and supported throughout the integration. The role will also ensure a seamless transfer of financial information, institutional knowledge, and ongoing accountabilities to Vertex functional finance teams as the integration progresses. The Senior...

The Health Systems Marketing Associate Director is responsible for the development and execution of key personal and non-personal promotion marketing tactics targeting Health Systems and hospitals. Specifically, this role will own the evolution of formulary decision maker messaging, core Health Systems promotional materials (value proposition and economic tools), and digital media strategy and execution. Vertex recently launched JOURNAVX, an oral, non-opioid medication for the treatment of moderate-to-severe acute pain. Promotional education is critical to the success of JOURNAVX. This role will develop high impact personal and digital promotional content and work closely with colleagues on the health systems marketing team,...

Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. The Senior Manager Director role is within HEOR’s Analytics Center of Excellence (CoE), a specialized team that provides strategic and technical support to HEOR, Market Access & Pricing, and the broader commercial organization. In this role, the Senior Manager will primarily support HEOR disease/asset teams in real-world observational and claims data research activities. The Senior Manager will support colleagues looking to answer key questions that can be...

The Director, Chemistry Manufacturing Controls (CMC) leads a Regulatory CMC team responsible for developing and executing global regulatory strategies across multiple investigational and commercial products in the small molecule portfolio. This role provides strategic leadership for complex regulatory CMC activities, oversees Health Authority engagement, and ensures regulatory requirements are effectively integrated into development and commercialization plans. The Director drives organizational excellence through talent development, process innovation, and the application of digital and AI-enabled capabilities to enhance the quality, consistency, and efficiency of regulatory decision-making, document preparation, and submission execution. Key Duties and Responsibilities Leads development and execution of global CMC...

JOB TITLE Analytical Development Principal Research Associate LOCATION 316 Northern Ave., Boston, Massachusetts 02210 OPENINGS 1 DUTIES Independently perform complex experimental procedures using various technical platforms, including ELISA, flow cytometry, cell culture, cell-based bioassays, and HPLC, designed through collaboration with supervisor. Independently develop ELISA and plate-based binding assays with minimal oversight, in accordance with USP guidelines for biologic assays. Improve and transfer a research-grade assay to a GMP test lab. Work collaboratively with cross functional teals providing technical support to achieve program goals within established timelines and demonstrating excellent documentation skills. Report experimental findings and results to team...

The Associate Director, CMC Quality Compliance and Inspection Readiness, is responsible for inspection readiness and compliance of external sites including evaluating, improving, and monitoring commercial level quality compliance and quality culture. Key Duties and Responsibilities Responsible for inspection readiness and compliance programs for external operations. Works cross-functionally and cross-company to ensure sites achieve and maintain a state of inspection readiness. Drive identification and resolution of issues, gaps and risks through collaboration with operational areas, assessments, audits, and evaluation of trends. Support and oversee inspection execution including responses and closure of CAPAs. Collaboration and Integration Serve as an integrator across multiple...

The CMC Quality Compliance Director is responsible for inspection readiness and compliance of internal and external sites including evaluating, improving, and monitoring commercial level quality compliance and quality culture. This position provides technical and strategic leadership for inspection readiness and compliance including processes and associated governance across all GMP areas. This position focuses not just on the “what” but the “how”, ensuring phase appropriate and risk-based compliance. Key Duties and Responsibilities Accountable for inspection readiness, inspection management, and compliance programs across all GMP areas including external CMOs and internal manufacturing/testing sites. Monitor and interpret cGMP regulatory guidelines and trends in...

General / Vertex is entering a transformative phase in its AI journey, where responsible, trusted, and compliant AI is foundational to accelerating innovation, improving patient outcomes, and enabling enterprise-wide productivity. We are seeking a visionary and execution-focused Director, AI Governance & Policy to lead Vertex’s enterprise AI Governance program and establish the policies, operating models, and technology platforms that enable safe, ethical, and business-enabling adoption of AI across the company. This role will lead the governance of generative AI, agentic AI, machine learning, and AI-enabled business solutions. The Director will oversee AI policy development, risk management, governance operations, technology...

Analytical Development Principal Research Associate Job Location 316-318 Northern Ave, Boston, 02210 Openings 1 Job Type Full Time Duties Design, develop, execute and analyze characterization and release assays for identity, purity, strength and potency of cell- based products. Multiple analytical platforms will be employed including RT-qPCR, SDS-PAGE, ELISA, Western blots, Flow cytometry, Flow-cam, ddPCR, Alphalisa and cell- based functional/ potency assays. Execute test methods in support of pluripotent stem cell Process Development activities. Troubleshoot, optimize, and trend assay performance. Report on project progress, write analytical development protocols and reports, provide recommendations to management. Identify, qualify, and manage analytical reagents as...

The Project Management & Strategic Senior Manager is responsible for multiple department projects and provides centralized operational support for the U.S. Commercial team. By partnering with departmental management and cross-functional project teams, the Senior Manager develops and maintains integrated project plans and operational processes in accordance with project/department objectives, and are within budget. The Senior Manager is also responsible for comprehensive communication, including status reporting, risk management, and department processes to cross-functional stakeholders and department senior leaders. The Senior Manager partners closely with the Chief of Staff, U.S. Commercial to execute on strategic, operational, and organizational matters. Key Duties and...

Vertex is seeking an experienced and strategic leader for the US Commercial Field Technology / CRM team. The Director, Field Technology is responsible for setting the strategy and leading execution for CRM and US commercial field technology enablement. This role ensures commercial field teams are equipped with effective, scalable technology that drives engagement, productivity, and decision-making. This leader will play a critical role in shaping and operating integrated technology and data solutions for the field , connecting business needs with CRM capabilities, processes, & governance. The role requires deep expertise in commercial systems leadership, CRM adjacent field operations processes and...

Vertex is seeking a Senior Research Scientist to join Analytical Development in Boston, MA . This role supports the advancement of transformative medicines by leading analytical chemistry activities across all stages of clinical development. The position is part of the Chromatography Subject Matter Expert (SME) team , focused on small molecules and synthetic peptides/oligonucleotides , with particular emphasis on drug substance, drug product intermediates, and drug product . Key Duties and Responsibilities Lead chromatographic method development, qualification, and validation activities. Partner with cross-functional project teams to design, oversee, and review analytical methods, validation protocols, and reports . Serve as a...

Company Overview Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. We are committed to improving the lives of patients through bold science, advanced technology, and a collaborative, mission-driven culture. At Vertex, employees are empowered to solve complex challenges in an environment that values innovation, integrity, and excellence. The Principal Cybersecurity Engineer, Core Security Infrastructure is a technical leader responsible for shaping and advancing Vertex’s core security capabilities across network, cloud, application, AI, SaaS, and hybrid environments. This role serves as a deeply technical engineering leader focused...

The Stem Cell Research Scientist works with some independence and is adept at conceptually outlining studies to design and execute focused research projects or a series of complex experimental procedures including the development of human hematopoietic cell models and assays to evaluate targets and lead molecules for Vertex diseases. Completes work in a resourceful, self-sufficient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientific literature relevant to scientific methodology or field(s) of technical expertise. This level captures both the Research organization’s entry level for staff with a research doctoral degree (PhD) and...

Through internal audits the Internal Audit Manager will identify risk areas, evaluate business process controls and complete test plans on operational audits. Additionally, this role will provide recommendations to improve the effectiveness and efficiency of operations and business systems. This role will also participate in ensuring that the yearly internal control review is brought to fruition by interacting with SOX testers, other stakeholders, and subject matter experts on special projects and the development and execution of departmental goals. Key Duties and Responsibilities Maintain strong knowledge of Vertex’s core business and assist in developing a risk and control assurance program aligned...

The Executive Director serves as a strategic leader responsible for defining and executing the Cell & Genetic Therapies (CGT) Quality vision, operating model, and organizational strategy. The role is accountable for ensuring quality readiness from early development through commercialization while building scalable, inspection-ready quality capabilities across internal manufacturing sites and external partner networks. The position drives enterprise CGT quality leadership, digital innovation, talent development, and risk-based decision making to support the successful delivery of life-changing therapies to patients. The role includes partnering with internal stakeholders to build & coordinate a phase appropriate quality roadmap to commercialization. Key Duties & Responsibilities...

The Senior Manager is a key member of Vertex's Financial Planning & Analysis team, providing financial direction and strategic insight to the US Pain Business Unit including identification of key value drivers and Business KPIs, helping the business unit deliver short term and long term goals, and influencing strategy. This role will help drive our annual budget process and will partner closely with functional teams to drive the financial performance management process (objective setting, budget vs. actuals, etc.). The role will also place a critical role in updating quarterly forecasts, with a focus on influencing business operations and decisions through...

The Director, External Manufacturing Cell and Genetic Therapies , role is to oversee and manage Vertex’s critical cell and gene therapy Contract Manufacturing Organizations (CMOs) and implement our vision for this business-critical function. The role requires a candidate with the breadth of professional experience and the drive to work with both internal and external partners to define and manage the ongoing cGMP supply of cell and gene therapy products that supports clinical through post-approval lifecycle management. The ideal candidate will understand the challenges and make proactive operational decisions, taking into consideration cross-functional and patient impact. This role requires a strong...

The Finance Controller (Senior Manager) is a key member of Vertex’s Chief Operating & Financial Officer (COFO) organization, reporting to the Finance Controller (Director). The role serves as a strategic partner and subject matter expert for functional Finance teams including Research, Development, Biopharmaceutical Sciences & Manufacturing Operations, Commercial, G&A and Corporate Finance. The Senior Manager designs, implements, and leads continuous improvement of processes, policies, and procedures to advance an agile, strategic and compliant Finance organization. Key Duties and Responsibilities Lead strategic, cross-functional initiatives across the COFO organization, partnering with Finance, General Ledger Accounting, Technical Accounting, SEC Reporting, Record-to-Report Strategy &...

We are seeking a strategic, influential, and Data/Technology/AI-savvy Senior Director, HR Business Partner to partner directly with the Chief Digital & Information Officer (CDIO) and lead the people agenda for Vertex’s Data, Technology & AI organization. This role ensures the operating model, leadership capability, and enterprise talent strategy are in place to execute the Data/Tech/AI roadmap as AI transforms how work is delivered. This is a senior individual contributor role that leads through influence and serves as the primary people strategist for the Data/Tech/AI function. The role owns talent strategy and organizational effectiveness across the enterprise, driving transformation through...

The Executive Medical Director, Global Medical Lead (GML), Nephrology is a critical leadership role in Global Medical, responsible for the global medical strategy and implementation and tracking of global activities for a designated disease area(s). Key accountabilities include, but are not limited to, disease area specific Integrated Medical Plan development, including the publication plan, integrated evidence generation plan, global medical launch strategy and execution, scientific leadership, external medical expert engagement, and strategic alignment with commercial and other cross-functional business partners.. This leader reports directly to the VP, Global Medical and is a core member of the Global Medical leadership team....

Vertex is seeking a talented marketing professional to join the US Pain Business Unit to support the HCP experience with JOURNAVX . The Associate Director, HCP Experience will play a critical role in shaping and delivering best-in-class experiences for healthcare professionals (HCPs) as we continue the launch of JOURNAVX, a novel selective pain signal inhibitor of NaV1.8 in acute pain. This role will focus on designing and executing integrated HCP engagement strategies across key touchpoints of the education and prescribing experience . The individual will work closely with the Senior Director, HCP Marketing to bring the HCP strategy to life...

As an experienced Talent Acquisition specialist, the Associate Director implements and executes recruitment strategies and programs to attract best in class talent for critical openings. Establishes effective partnerships with search specialists and hiring managers to create and manage talent pipelines, coordinate recruiting initiatives, and leverage relationships with third party search partners. Key Duties and Responsibilities Design and implement approaches to identify and attract top talent to the organization inclusive of both organic attraction techniques and partnerships with external staffing partners. Build talent pipelines for near-term and longer-term organizational capability and capacity needs. Conduct proactive talent pipelining and sourcing initiatives leveraging...