Vertex Job Trends

The Associate Director, GxP Operations Support Manufacturing Systems will provide strategic leadership for the design, delivery, administration, and continuous improvement of the site Manufacturing Execution Systems (MES) and manufacturing control system platforms supporting commercial and clinical operations. This role serves as a key business and technical leader responsible for advancing agile digital manufacturing capabilities. The Associate Director will partner across Manufacturing, Quality, Validation, Information Technology, and Engineering organizations to ensure compliant, reliable, and scalable manufacturing systems. The role will also support lifecycle management of manufacturing systems including data integrity, industrial networking, historian platform integration, and cybersecurity. Key Duties and Responsibilities...

We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using a broad range of computational approaches including molecular modeling, cheminformatics, data science, and AI-enabled methods. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively within the global Data and Computational Sciences group to provide expertise in data analysis, computational chemistry and AI method development. This individual must demonstrate strong...

We are seeking a Computational Genomics Research Scientist to support the development of transformative cell and gene therapies across Vertex's research portfolio. This Boston-based position is part of the global Data and Computational Sciences organization and will collaborate closely with research teams spanning stem cell biology, immunology, gene editing, and pre-clinical development to design studies, execute and analyze complex genomic analyses, and ultimately generate biological insights that drive early research across multiple disease programs. As an embedded computational scientist, you will be responsible for performing bulk and single-cell sequencing analyses , spatial transcriptomics, and multiomic profiling to help uncover the...

The Senior Director, Immunology will oversee multiple research programs and initiatives that support the research and development of the Vertex portfolio, and collaborate closely with manufacturing, process and analytical development colleagues to support the development of advanced therapies. This role will be responsible for driving execution of current projects and leading the identification of new opportunities. This individual will help define and drive immunology research strategies, lead the development of novel immunomodulatory approaches to enable transformative advances in allogeneic transplantation, and provide scientific leadership across a diverse portfolio of discovery and development programs. Through deep scientific expertise, strategic vision, and...

The Audit & Compliance Manager manages and coordinates audit, inspection, and compliance activities across Data, Technology & Engineering (DTE) and business functions. This role serves as the primary liaison between operational teams and auditors, ensuring timely preparation, execution, response, and remediation of Internal Audits, GxP audits, and regulatory inspections. The role partners closely with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations are fulfilled. General Responsibilities Serve as the primary DTE point of contact for IT-related audit, inspection, and compliance requests across GxP, Internal Audit, and operational audit...

The Strategic Operations Manager, Preclinical Sciences will play a critical role in driving operational excellence across the Preclinical Sciences organization. This position will partner closely with Procurement, Legal, Outsourced Contracting, Lab Operations, and Records Management to support business operations, improve processes, and enable efficient execution of departmental priorities. The ideal candidate is a highly organized and agile operations professional who thrives in a fast-paced environment , can manage multiple priorities simultaneously, and is experienced in supporting change management initiatives and driving efficiencies across cross-functional teams. Key Duties and Responsibilities Partner with Research & Preclinical Sciences leadership to support strategic and...

We are seeking a Senior Research Scientist in Computational Genomics to join Vertex's Data and Computational Sciences organization at our San Diego research site. In this role, you will work at the intersection of human genetics, genomics, and modern computational approaches, including emerging AI technologies, to accelerate the development of transformative therapies for serious human diseases. Working closely with cross-functional disease project teams, you will help shape the development of novel therapies in areas including lung diseases and pain by designing human genetic and genomics studies and translating complex datasets into insights that inform program strategy, target evaluation, biomarker development,...

Vertex is seeking a highly experienced and motivated Principal Research Associate to support discovery and optimization of Lipid Nanoparticles (LNPs) by developing, optimizing, and applying advanced in vitro cellular models and executing cell-based assays to evaluate delivery, uptake, and pharmacological activity of LNPs. This role is primarily laboratory-based and will focus on technical execution and method development across screening workflows and related delivery biology studies. Key Duties and Responsibilities Establish, optimize, and apply advanced 2D and 3D cellular models using primary cells, organoids/spheroids, and advanced cell culture platforms. Execute and optimize automated cell-based assays and lead screening activities by generating...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Senior Director, Analytical Development is a senior leadership role within the Cell and Gene Therapy Analytical Development function and will be responsible for setting and driving the company’s analytical testing strategy, including manual and automated testing approaches, analytical operations, and implementation of automation capabilities. This leader will oversee teams focused on automation of assays, testing in support of process workstreams, and analytical operations such as reagent and assay control management. The role will work closely with Manufacturing, Process Development, Regulatory, Quality, CMC, and external partners to generate high-quality data that informs strategy and decisions, while advancing next-generation analytical automation...

The Senior Director, Government Pricing will lead the tactical, compliance, and strategic oversight of the Government Pricing and Transparency team. The team is comprised of complementary functions Government Pricing Operations, Compliance, and State Price Transparency. This position will collaborate closely with the Managed Markets Specialty Pharmacy and Payer Field teams, Accounting, Legal, Finance, Global Information Systems, Government Affairs and Public Policy, OBIE, Treasury, Regulatory, Quality, and Pharmaceutical Operations. This role will demonstrate a level of detail, strategic understanding of Vertex business priorities, and executive presence. Key Duties and Responsibilities Serve as subject matter expert on Government Pricing calculations, methodologies, reporting...

The Patient Safety Senior Medical Director will provide leadership for all safety and risk management activities for assigned products, pre- and/or post-approval. This role will lead Risk Management activities, pre-, peri- and post-approval (as applicable) for assigned compound(s) and will provide relatively autonomous leadership of periodic (aggregate) safety report, signaling, labelling and DST activities for assigned compounds, as well as participate in individual case medical review. This role will lead representation, as safety lead, on clinical teams/programs, regulatory filings and submissions and other intra and/or inter-departmental activities and initiatives, including process/SOP development, audits and inspections. Key Duties and Responsibilities Represents...

As the Associate Director of Strategic Sourcing for Cell and Gene Therapy (CGT) Raw Materials, you will be part of a fast-growing and innovative organization at the company’s world headquarters in Boston, MA. The department is committed to a trusting and collaborative culture where growth and development are valued. We engage proactively with stakeholders to understand their needs and deliver results for our company and for patients. If you are looking for an entrepreneurial, hands-on, team-oriented environment where you can make a meaningful impact, this is the right place for you. The role is responsible for raw materials sourcing categories...

As the Sales Planning and Field Effectiveness, Associate Director you will be responsible for the administration, execution, and delivery of incentive compensation, targeting, sales planning, and field effectiveness. This role partners closely with business unit leadership and cross-functional stakeholders to translate brand strategy into practical field execution solutions that improve commercial performance. This position requires a hands-on leader with expertise in pharmaceutical incentive compensation, targeting strategy, sales operations, analytics, and data management. The role supports targeting prioritization, incentive plan design & delivery, performance monitoring, and process improvement to help maximize sales force productivity, customer engagement, and execution quality. This is...

The Epidemiology Forecasting team develops patient population forecasts used to inform commercial opportunity and forecasting, clinical trial planning, long-range planning, regulatory filings, and external communications. The Director, Epidemiology Forecasting is responsible for supporting programs through the execution of strategic plans to obtain scientifically rigorous global estimates of the incidence, prevalence, and population size for diseases being investigated for treatment. The role will report to the Senior Director, Epidemiology Forecasting. Key Responsibilities Lead systematic literature reviews and database/disease registry studies and contribute to primary observational studies to ensure the development of scientifically rigorous estimates of disease incidence, prevalence, and population size...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The GCO AI Enablement and Analytics Associate Director serves as the business-embedded technical expert responsible for advancing AI-enabled business transformation, advanced analytics, automation, and digital capabilities across Global Clinical Operations (GCO). As a key member of the Digitization Strategy Center of Excellence, this role will help shape and execute GCO's AI enablement and analytics strategy to improve the efficiency, effectiveness, and scalability of clinical trial execution. The individual will operate at the intersection of clinical operations, process transformation, analytics, and emerging technologies. This role will provide the technical expertise needed to bridge clinical operations business needs with AI and digital...

General/ The Director of FP&A, Value Architecture leads development and management of the value case for AI transformation initiatives, including the value hypothesis, financial model, KPIs, and measurement approach . The role partners with Digital, Technology and Engineering, Finance, Portfolio Strategy, functional leaders, and the CFO organization to ensure value cases are credible, operationally grounded, affordable, and measured consistently. This role provides the evidence base for portfolio-level value reporting and investment decisions, helping leaders understand value drivers, risks, opportunities, and business KPIs across the transformation portfolio. Key Duties & Responsibilities Value Case Development Define the value hypothesis, KPIs, and measurement...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Senior Medical Science Liaison (Sr MSL) will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide the...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Senior Administrative Assistant will serve as a trusted administrative partner to the Vice President, U.S. Government Affairs & Patient Advocacy; the Vice President, Federal Government Affairs; and the Executive Director, State Government Affairs. The role is responsible for complex calendar and travel management, meeting and event coordination, contracting and invoice administration, executive preparedness, and broader team operations. The successful candidate will work with a high degree of independence, judgment, discretion, and attention to detail while managing competing priorities and interacting professionally with senior internal and external stakeholders. Key Duties and Responsibilities Executive and Stakeholder Support Serve as a primary...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer. Key Duties and Responsibilities Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools) Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group Demonstrates in-depth knowledge of clinical development and medical data Solves complex clinical trial reporting problems...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The Manager of Commercial Rebate Operations has a critical role, reporting into the Associate Director, Rebate Operations team within the US Market Access organization. This is an exciting opportunity for a subject matter expert that applies an enterprise-level mindset and technical expertise at the intersection of data, process optimization, automation and innovation. The ideal candidate is passionate about patients, focused on driving for results, and is willing to be involved in hands-on execution while building new functional capabilities. The successful individual must be adept at cross-functional collaboration, while also having a high degree of attention to detail and accuracy to...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

At Vertex, we’re relentless in our pursuit of scientific innovation to create transformative medicines for people with serious diseases. We are currently seeking a Gene Therapy Account Manager (GTAM) to support our Sickle Cell Disease (SCD) and Transfusion-dependent β-thalassemia (TDT) Heme Business Unit. This role is responsible for the Southeast territory which includes FL, GA and AL As part of a national team, the Gene Therapy Account Manager, Associate Director (GTAM) will approach each day with a passion for improving the lives of people living with Sickle Cell Disease and Transfusion-dependent β-thalassemia. This role is focused on Key Account Management...

General/ The Pain Regional Account Manager is a field-based role responsible for delivering flexible, high-impact coverage across the Pain Business Unit to address territory vacancies, leaves of absence, and priority business needs. The role reports to the Area Field Leader and is deployed based on regional business needs. Pain Regional Account Managers are deployed dynamically across geographies to maintain business continuity, support priority accounts, and drive execution against commercial objectives. Depending on business need, the role may assume PTAM or TBM responsibilities and is expected to quickly establish continuity across key customer relationships, accounts, and business priorities. When not covering...

The successful candidate will work in a team setting and be responsible for coordinating production of program-relevant cell types such as stem cell-derived islets (SC-islet) for use across research team projects. This includes 2D and 3D culture of pluripotent stem cells as well as differentiation for in vitro and in vivo studies. A demonstrated strong understanding of best lab practices to ensure reliability, consistency, efficiency, and quality control, as well as dedication to lab bench work, are required. Key Duties and Responsibilities Culture human stem cells in 2D and/or 3D Completes experiments in a reliable, consistent manner Demonstrates a high...

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition and supporting evidence of Vertex’s innovative renal pipeline asset, povetacicept , a dual inhibitor of the BAFF and APRIL pathways, currently in phase III. This position reports to the Senior Director Global HEOR, Kidney. Key Duties and Responsibilities Leads others to execute complex HEOR evidence generation including, cost-effective analysis and budget impact models, prospective...

Key Responsibilities Perform revenue recognition evaluations under ASC 606 for new product launches, new contracts, and reimbursement agreements Review new agreements and complex gross-to-net matters and help ensure technical accounting conclusions are applied consistently and appropriately by local accounting teams Document accounting policies related to revenue and gross-to-net matters in collaboration with International and North America revenue accounting teams, as needed Partner with cross-functional teams that review and support the contract drafting process Work closely with global accounting, finance, and commercial organizations to support internal and external financial revenue reporting requirements Partner with the SEC Reporting team to prepare revenue-related...

At Vertex, we continue to invest in a future-ready workforce where AI helps people strengthen expertise, improve decision-making and create greater impact for our people and patients. We are looking for a Director, AI Transformation Operations to build the operating model that helps Vertex move AI reinvention projects from strategic decisions to coordinated execution. Reporting to the VP, AI Transformation, you will connect strategy, governance, and delivery across Vertex’s AI transformation, translating portfolio decisions into coordinated action, keeping teams aligned, and creating the visibility and accountability to deliver with clarity and speed. You will run the governance forums that guide...

The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program. Key Duties and Responsibilities Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and...

We are seeking a Senior Director / Director to lead the Value Realization Office (VRO) process for material, transformational initiatives across the project lifecycle. This role partners closely with project owners, executive sponsors, Finance, and DTE to define how value will be measured, establish baseline and reporting approaches, and monitor realized value against agreed objectives. The position is central to building a disciplined, consistent approach to value delivery, helping ensure strategic initiatives achieve measurable outcomes and addressing risks or variances when performance is off track. What You’ll Do Lead execution of the Value Realization Framework for in-scope, material, and transformational...

The Director, Commercial Training will work to enhance the skills and knowledge competencies of commercial and other relevant teams. This role will be primarily responsible for developing and executing training and development strategy ensuring commercial teams are equipped to excel. This role will work cross-functionally across a variety of internal stakeholders. This role involves leading a team, managing training portfolios, and fostering collaboration with cross-functional partners to drive exceptional performance. As a people manager within the organization, this role may have financial accountabilities and human resource responsibilities for assigned staff. Key Duties and Responsibilities Creates a comprehensive learning-strategy that supports...

At Vertex, we continue to invest in a future-ready workforce where AI helps people strengthen expertise, improve decision-making and create greater impact for our people and patients. We are looking for a Director, Enterprise AI Enablement to amplify the value AI creates across Vertex. Reporting to the Executive Director, Workforce Strategy & Innovation, you will lead the change management and enablement strategy to help employees, managers, and leaders consistently use AI with confidence, clarity, and accountability. Partnering across Workforce Strategy & Innovation, Learning, Internal Communications, Data Technology & Engineering, governance teams - and with leadership you will translate Vertex’s AI...

At Vertex, we continue to invest in a future-ready workforce where AI helps people strengthen expertise, improve decision-making and create greater impact for our people and patients. We are looking for a Senior Director, AI Transformation Strategy to help prioritize and coordinate the portfolio of big bets we are making to reinvent our most important workflows with AI. Reporting to the VP, AI Transformation, you will lead the enterprise portfolio strategy for Vertex’s AI transformation by prioritizing, sequencing, and tracking the portfolio of reinvention projects, to ensure we scale responsibly and strategically. You will provide senior leaders with a clear,...

The Director, Clinical Pharmacology leads strategic, scientific and operational aspects at a program level. This role represents the department on strategic and operational cross-functional program teams and will be responsible for the development of clinical pharmacology plans; assists in departmental management through program reviews and collaborative decision-making; supervises asset leads, provides career development; routinely co-leads cross-functional efforts and leads department initiatives. Key Duties and Responsibilities Guides metabolic, co-dosing and drug-drug interaction issues, collaborating closely with cross functional colleagues Co-leads or serves on cross-functional committees and/or contributes to or leads departmental initiatives Creates protocol concepts and guides protocol start-up including site...

The CMC Statistics Director (Scientific Fellow) provides strategic and technical leadership for the application of statistical sciences across the product lifecycle, including process development, analytical development, manufacturing, process validation, continued process verification (CPV), stability, quality control, and regulatory submissions. This individual will establish and lead the CMC Statistics capability, enabling data-driven decision-making to enhance product quality, process robustness, operational efficiency, and regulatory compliance. The role partners closely with Development, MSAT, Quality, Regulatory Affairs, and Data & Digital teams to ensure the effective application of advanced statistical methodologies across all CMC functions. The position will drive the adoption of best practices...

Manager, Marketing Operations The Marketing Operations Manager serves as the lead and subject matter expert for assigned Communications Review Committee (CRC) team(s), supporting the efficient and compliant review, approval, production, and distribution of branded and non-branded communications. This role partners closely with business stakeholders, agency partners, and cross-functional reviewers to help ensure materials move through the promotional review process in a timely, well-coordinated, and effective manner. In addition to leading planning, forecasting, and review operations for assigned CRC team(s), this individual is responsible for generating performance insights, leading quarterly business reviews, and driving continuous improvement initiatives that enhance efficiency,...

The Associate Director, FP&A is a key member of Vertex’s Finance Business Partnering organization, providing financial leadership and strategic support to the U.S. Kidney team. As Vertex advances toward commercialization of its Kidney portfolio, this role will help shape and deliver near-term and long-term financial goals. This position will play a critical role in supporting pre-launch contracting strategies and post-launch commercial revenue planning in the U.S., a priority market for the Kidney portfolio. The Associate Director will partner across Finance, Market Access, Commercial, Trade, and Analytics to deliver actionable insights, inform decision-making, and help define the key performance indicators that...

The Director, Intellectual Property Operations is responsible for leading and continuous ly improv ing Vertex's IP Operations function. This role focuses on driving operational excellence through strong project execution, project management, communication, collaboration, and managing a team supporting patent and trademark administration, docketing, annuities, budgeting, software assessment, developing standard practices and vendor engagement and management. The position also serves as a key partner to IP attorneys, Finance, Technologists , and external counsel to ensure efficient processes, data integrity, compliance, and successful delivery of strategic initiatives . The Director will report directly to the Executive Director , Intellectual Property for Cell...

The Analytical Science and Technology (AS&T) Principal Scientist, Separation Method Expert, will be responsible for providing scientific and technical expertise within and across functional areas for late-stage & commercial methods and vendor management. S/He will manage the method life cycle, including method remediation, validation, transfer, troubleshooting and investigations for OOT/OOS, along with data trending analysis. Additionally, the principal scientist will partner closely with all stakeholders, and with contract testing sites establishing partnerships to ensure compliance with cGMP and Quality Management systems for the global network to deliver our medicines to patients effectively. Key Duties and Responsibilities Lead analytical method remediation,...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

We are seeking a Senior Director, US New Product Planning, to help shape the future of our pipeline and build the foundation for successful US launches. This is a highly visible leadership role for a strategic, commercially minded, and pragmatic leader who thrives at the intersection of asset strategy, US market planning, and enterprise capability building. This role is ideal for someone who has worked in both the US business and on global teams, and who understands what it takes to succeed in the US market across functions—not just within a single discipline. The individual will represent the US perspective...

We are seeking a Director, US New Product Planning, Early Market Development to partner closely with the Senior Director Director, US New Product Planning in preparing early pipeline assets for future US success. This role is ideal for a commercially minded, externally oriented leader who is energized by shaping markets well ahead of launch. The successful candidate will focus on early market development and engagement with emerging thought leaders, including both healthcare professional (HCP) stakeholders and patient advocacy / community leaders. This individual will help build the foundational understanding, relationships, and market readiness required to support future launch success in...

We are seeking a Senior Director, US New Product Planning to help shape the future of our pipeline and build the foundation for successful US launches within an expanding and highly visible Business Unit. This is a high-impact leadership role for a strategic, commercially minded, and pragmatic leader who thrives at the intersection of asset strategy, US market planning, launch readiness, and Business Unit build-out. This role is ideal for someone who has worked in both the US business and on global teams, and who understands what it takes to succeed in the US market across functions—not just within a...

Vertex is seeking a highly skilled Senior Azure DevSecOps Engineer to design, implement, secure, and optimize cloud platforms that power enterprise software, data, and AI-driven solutions. This role will be a key technical contributor supporting VaiDA and other strategic initiatives built on Microsoft Azure, Microsoft Foundry, and related cloud technologies. Working closely with software engineers, cloud architects, information security teams, and business stakeholders, this individual will drive the adoption of DevSecOps best practices, cloud automation, infrastructure as code, and secure software delivery pipelines. The ideal candidate combines deep Azure expertise with a strong security mindset and a passion for building...

Job Summary Vertex is seeking a Senior Director, Market Transformation to help position the company as a commercial leader in delivering life-changing medicines to patients through innovative capabilities, cutting-edge solutions, and strategic partnerships. This role will identify emerging market trends, bring external insights into the organization, and translate opportunities into scalable programs that increase awareness for our brands, improve patient access, and support business objectives. The Senior Director will work cross-functionally to shape strategic decisions, accelerate innovation, and strengthen relationships with influential stakeholders across the healthcare ecosystem. This leader will play a critical role in improving patient access to our...

The Director, Marketing Operations, Promotional Materials Management will lead Vertex’s centralized promotional materials operations function across all U.S. products and businesses. This role is responsible for the end-to-end operational management of promotional material review, approval, production, distribution, and lifecycle management, ensuring efficient, scalable, and compliant execution. This leader will operationalize and continuously improve the review committee SOP, strengthen review committee practices across the organization, and drive measurable improvement across people, process, and platform. The role will also oversee coordinator services, including a team of five FTEs, and serve as a key partner to Commercial, Legal, Regulatory, Medical, Compliance, and external...

The Modeling & Simulations Associate Director will be responsible for developing and executing M&S strategies and activities in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization. This role determines, plans, and executes technically challenging analyses b y using state of the art Modeling & Simulation methodologies to strongly contribute to critical decision making. Key Duties and Responsibilities As Modeling & Simulations (M&S) lead in one or more cross functional drug development teams, responsibilities include the development and execution of Modeling & Simulation plans and analyses...

Vertex is seeking a talented individual to join our Process Development team as a Scientist. The primary focus of this role is to lead and manage the execution of development studies for a cell-based drug candidate designed to treat diabetes. This is a full-time position based in our Boston, MA facilities, with occasional weekend work required. The Process Development group offers a fast-paced and high energy environment. The right candidate will be a subject matter expert in bioprocess engineering and have a solid technical operations background. Key Duties and Responsibilities Design and execute experiments to develop robust manufacturing processes for...

Reporting to the Director, Materials Operations, this role is responsible for developing and executing the Materials Management Technical Support strategy for Manufacturing support operations, material control process design, compliant material flows, and system reconciliation in support of product commercialization. The individual will also support key Materials Management systems and processes, including change controls, risk assessments, deviations, and GMP documentation. This role provides oversight of commercial material control process development, materials management system design, warehouse material flows and performance monitoring. The Senior Manager will collaborate cross-functionally with Manufacturing, Process Development (PD), Quality Control (QC), Operational Quality, Facilities, Operations, and other stakeholders...

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities. Participates...

The Associate Director, Kidney Training & Development is a strategic leadership role responsible for designing and leading capability-building initiatives that support the success of the Kidney business at Vertex. This position oversees more than traditional training and development activities and plays a critical role in advancing leadership development, organizational effectiveness, and field readiness. In addition, this role serves as the primary training lead for our customer engagement liaison team. The Associate Director partners closely with Commercial, Medical, Market Access, HR, Compliance, and other key stakeholders to build a high-performing, customer-centric, and compliant organization. Key Duties and Responsibilities Design, implement, and...

Vertex is seeking a strategic and collaborative marketing professional to join our US Kidney Business Unit to support our aspirations of bringing Povetacicept to patients, a Phase 3 investigational therapy that has the potential to transform lives across multiple serious diseases. The Senior Marketing Manager, US Kidney - Pove will lead the strategic execution for the HCP marketing team alongside The US Kidney marketing team, which is preparing for potential commercialization of an investigational therapeutic being studied for the treatment of Immunoglobulin A nephropathy (IgAN) and other B cell-mediated diseases. This individual will lead the development and execution of marketing...