Vertex Job Trends

General/ The Director, US Heme Care Manager Team Lead is responsible for the daily operations of the Heme Care Manager team within the Vertex Patient Support Business unit which provides dedicated support to the US, Heme Business Unit. This individual will play a key role in ensuring exceptional support is provided to our customers by our care manger team. This critical role will be highly cross functional within Vertex with the goal of providing industry-leading patient support through patient facing interactions and logistical coordination. The Heme care manager team is responsible for the coordination of logistical support for the end-to...

Vertex Pharmaceuticals is seeking an Associate Director (AD) of Kidney Field Training & Development to join the North America Commercial Field Training (NACFT) organization. Reporting to the Director, North America Commercial Field Training – Kidney, this individual will play a critical role in preparing our field organization for launch excellence across Vertex’s Kidney portfolio. The AD will partner closely with cross-functional Kidney BU leaders in Marketing, Medical Affairs, Market Access, and Field Leadership to design, deliver, and continuously evolve learning solutions that build deep scientific fluency, confident messaging, and customer engagement excellence across our field and field leadership teams. Key...

The Customer Engagement Platform Architect will serve as the strategic and technical lead responsible for designing, optimizing, and scaling Vertex’s customer engagement platforms across marketing, field CRM, and digital channels. This individual will play a critical role in shaping the future-state architecture that enables seamless, compliant, and personalized engagement with healthcare professionals (HCPs), patients, and caregivers. The role requires deep expertise in enterprise platform integration, data-driven engagement, and governance, with a focus on ensuring scalability, compliance, and business value. Key Duties and Responsibilities Platform Architecture & Strategy Define and maintain the enterprise architecture for customer engagement platforms (e.g., Salesforce Marketing...

Vertex’s Data, Technology and Engineering (DTE) team is seeking a technology operations leader to join our Project Management and Strategic Operations group. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Senior Manager, Strategic Operations will tackle the toughest challenges of how we work across DTE and cross-functionally to deploy technologies that scale our business. This role requires close partnership with technology leaders to identify gaps, design and implement improved processes, monitor outcomes and communicate results to...

The GMP Operational Quality Senior Specialist supports the principles and application of quality assurance and regulatory compliance. The incumbent supports or executes a wide range of straightforward activities, and supports new/existing project initiatives. This role provide QA support of manufacturing operations, analytical laboratory operations and materials management for the external manufacturing programs at VCGT. This role will review batch data, including batch records, deviations, in-process data, EM data, QC release testing and other quality systems documentation as needed in support of product disposition. Key Duties and Responsibilities Supports quality oversight for root-cause analysis and product impact assessment for investigations as...

The Associate Director, Strategy and Operations, US Market Access is a key partner and advisor to the VP US Market Access and Market Access Leadership Team (MALT) on a variety of strategic, operational, and organizational matters. The role requires both strategic thinking as well as the ability to drive operational execution through preparing, implementing, and effectively managing tactical initiatives. The ideal candidate is a highly motivated and highly organized individual with exceptional emotional intelligence, communication skills and judgment with the ability to manage complex details, understand the business, and drive action. This role reports directly into the Vice President of...

Patient Support Vendor & Program Operations Manager Department Patient Support Vendor & Program Operations, Center of Excellence Location Boston, MA (Hybrid – 3 days per week on-site) Vertex is seeking a Manager to join the Patient Support Operations & Vendor Management Team within the US Patient Support Center of Excellence . This team supports Vertex North America Commercial’s Patient Support organizations, which assist patients living with Cystic Fibrosis, Sickle Cell Disease, Beta-thalassemia, and Acute Pain. The Patient Support Operations & Vendor Management Team oversees patient support vendors, including those managing financial assistance programs, benefits investigations, prior authorizations, and travel...

Job Title Director, Medical Affairs – Pain Department Medical Affairs Location Boston, MA, United States The Director, Medical Affairs – Pain will provide strategic medical leadership and oversee s the development and execution of medical strategies and plans for acute pain management in the U.S. region under the guidance of the Senior Medical Director . This role will focus on fostering scientific exchange, supporting evidence generation and scientific communications , and advancing disease education while ensuring compliance with regulatory and ethical standards. Additionally, the Director will play a key role in supporting and developing team members, including Scientific and...

This territory will include Bakersfield, Lancaster, Palmdale, and Santa Clarita Valley. The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or...

Principal Cloud Infrastructure Engineer Location Boston, MA (Vertex Headquarters) The Principal Cloud Infrastructure Engineer will lead the design, implementation, and optimization of enterprise-scale Azure cloud infrastructure with a strong emphasis on automation, operational excellence, and emerging AI technologies. This role will serve as a technical leader responsible for architecting resilie nt, scalable, and secure cloud solutions that support critical business operations while driving automation-first approaches and ITIL best practices. The Principal Engineer will champion the integration of GenAI capabilities to enhance infrastructure operations, reduce manual toil, and accelerate cloud service delivery across the enterprise. Key Duties & Responsibilities Azure...

Vertex currently operates at the forefront of rare disease scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), Sickle Cell Disease and Transfusion-Dependent Beta Thalassemia and Acute Pain. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in Type 1 diabetes, IgA Nephropathy (IgAN), APOL-1 Mediated Kidney Disease, among others. The Director, Market Access Strategy Lead – AMKD (inaxaplin) is accountable for leading and overseeing the development of Market Access (MA) strategies, tactical support programs...

Vertex currently operates at the forefront of rare disease scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF). In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in Type 1 diabetes, hemoglobinopathies, APOL-1 Mediated Kidney Disease (AMKD), Duchenne Muscular Dystrophy, Pain, and Alpha-1 Antitrypsin Deficiency (AATD). The Market Access Strategy, Senior Manager is responsible for supporting optimal market access across all marketed CF products, primarily Alyftrek and Trikafta, through designing and executing high-impact initiatives across...

The Senior Director, Clinical Pharmacology will serve as a Disease Area leader for Clinical Pharmacology. The Senior Director, Clinical Pharmacology will also manage the scientific functions and coordinate the activities of the Clinical Pharmacology function in collaboration with the other Disease Area leaders. The role’s responsibilities will include maintaining organizational processes across the group, influencing clinical program strategy, and integrating activities with other departments across the Global Research and Development organization, to help shape innovative and integrated clinical development plans. As a Disease Area leader, the Senior Director, Clinical Pharmacology will also direct Clinical Pharmacology efforts for small molecule and...

The Product Quality Associate Director is accountable for end-to-end quality oversight of small molecule program(s) throughout clinical development, commercialization, filing, approval, launch, and post-approval lifecycle management activities. This oversight includes setting and maintaining overall Quality strategies in support of commercialization efforts including establishing relevant product quality standards for current or novel technologies (including devices where applicable), ensuring QA and cross-functional alignment with industry and regulatory expectations, identifying product quality risks and mitigations throughout the development lifecycle of the assigned program, through commercialization and decommissioning. The candidate should have a good understanding of drug development and commercialization and be able to...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Associate Director, GMP Operational Quality is responsible for quality oversight of QC data review for both non-routine and routine cGMP process testing and in support of stability testing of Cell & Genetic Therapy products. The role will also oversee team activities, development of personnel and ensuring quality of deliverables within department purview. The incumbent has comprehensive knowledge of principles and application of quality assurance and compliance. The incumbent is responsible for development of group goals and projects ensuring alignment with corporate goals and compliance with all regulatory requirements, refining goals and projects when necessary. The incumbent not only coordinates...

Role Summary Supervise medical reviews for ICSRs during both clinical development and post-marketing, managing workflows and oversight to ensure evaluations are timely, accurate, and compliant. Serve as the main contact between operations and global patient safety medical teams. This position will contribute to setting standards, enhancing quality and inspection preparedness, executing vendor management, and working with both internal and external stakeholders to share medical expertise with operations teams and communicate operational regulatory requirements to the medical and PV Science groups. Key Responsibilities Lead the operational strategy and standards for ICSR medical review across all case types. Conduct thorough clinical evaluations,...

The Quality Manager is a technical resource in the principles and application of quality assurance and compliance. This position performs and leads activities “on the floor” in support of batch records review and disposition while ensuring compliance with cGMPs policies and procedures. The Quality Manager coordinates or executes activities on a wide range of projects and takes a role in the design and execution of new projects. Key Duties and Responsibilities Collaborate with internal and external business partners to resolve quality issues to ensure compliant solutions Lead root-cause analysis and product impact assessment for investigations as a result of deviations,...

The Quality Manager is a technical resource in the principles and application of quality assurance and compliance. The Quality Manager coordinates or executes activities on a wide range of projects and takes a role in the design and execution of new projects. The role will also have responsibilities associated with QC data review for both non-routine and routine cGMP process testing and in support of stability testing of Cell & Genetic Therapy products. This role requires collaborative interaction with cross-functional partners such as analytical and process development, clinical and commercial QC, and manufacturing operations to ensure the on-time closure of...

The Director, Cost Accounting leads financial close accounting, analysis and reporting of cost accounting valuation, inventory movements, reserves, and cost of goods, as well as other key accounting judgements and internal controls. In addition, the Director builds an operational strategy to support the growth of the Cost Accounting function in support of broader company objectives. The Director will work closely with various teams across the global organization, ensuring projects are in alignment with functional and corporate strategy. Key Duties and Responsibilities In collaboration with functional leaders, develops the overall strategy for cost accounting. Creates a framework to support the growth...

As the Associate Director of Sales Planning and Incentive Compensation you will be responsible for the administration, execution, and delivery of our Sales Planning & Incentive Compensation (IC) services for the US Kidney sales team. This includes the sales team alignments, targeting, and incentive compensation deliverables. You will be a strong collaborator with the business unit teams to proactively recommend sales planning and IC strategy to ensure alignment with brand objectives, as well work with internal team members, vendors, and provide individual work contribution in the delivery of these services to meet business expectations and on-time, quality deliverables. This is...

The Labor & Employment Senior Counsel will serve as a key legal advisor on labor and employment matters, providing strategic and practical guidance to Human Resources and business leaders. This Director-level role will join a team of lawyers reporting directly to the Head of Global Labor & Employment Law, guiding compliance with U.S. and international employment laws while fostering Vertex’s inclusive culture and supporting organizational growth. Key Duties and Responsibilities Provide timely, practical, and business-oriented legal advice on a broad range of employment issues, including recruitment, performance management, investigations, corrective action, reorganizations, terminations, leaves of absence, accommodations, discrimination, harassment, wage...

The Medical Science Liaison (MSL) will play a crucial role in supporting the pain program, with a specific focus on near-term launch. The MSL serves as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with (Allied) Health Care Providers/Professionals (HCPs) and other key stakeholders involved in healthcare decision making to ensure the appropriate dissemination of clinical, scientific, and health economic data with respect to pain and Vertex’s compounds in a timely, ethical, and stakeholder-focused manner. The MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contributing to the...

The Senior Director, Biomarkers, Immunology is an independent leader with wide-reaching scientific knowledge and expertise in immunology and biologics that can drive the biomarker strategy across the immunology portfolio, including in the identification, selection, and development of biomarkers. Experience in authoring and supporting regulatory filings required. The incumbent is an expert in the field of assay development and validation and works with a team and several external CROs to ensure fit-for-purpose validation of biomarker assays. The incumbent is a specialized technical expert in specific areas in biomarker development (e.g. CDx, immunoassays, genomic assays, flow assays, etc.) who can lead specific...

The Market Access Technical Lead will oversee technical operations for Vertex’s global revenue management platforms, including ModelN Flex and ModelN Global Pricing Management. This role ensures system integrity, optimizes technical workflows, and partners cross-functionally to support pricing strategies and compliance in a dynamic, global environment. Key Duties and Responsibilities Lead technical operations and configuration management for ModelN Flex and Global Pricing Management systems. Subject matter expertise on Chargebacks, Government Pricing, Medicaid, Commercial Rebates, 340B Validations, Membership Management Serve as the primary technical liaison between DTE, ModelN, and Application Service Providers for system enhancements and issue resolution. Oversee system integrations, data...

We are seeking a strategic, influential, and business- savvy HR Business Partner Senior Director to support the Biopharmaceutical Sciences & Manufacturing Organization (BSMO) at Vertex during a pivotal phase of growth and innovation. In this role, you will act as the key HR leader and strategic advisor to senior executives across one or more major BSMO sub-functions . Reporting to the Executive Director, HRBP Lead for BSMO, you will help shape organizational strategy, culture, and workforce plans that drive critical business outcomes and scientific advancement. This is a senior individual contributor position that leads through influence — operating as a...

Employer Vertex Pharmaceuticals Incorporated JOB TITLE Analytical Development Scientist LOCATION 316 - 318 Northern Avenue, Boston, Massachusetts 02210 OPENINGS 1 DUTIES Perform a variety of well-defined, supportive functions including leading design and execution of analytical procedures that support development of cell therapy products. Develop, qualify and validate new test methods for characterization, purity and potency of hESCs and iPSC derived cell intermediates and drug products. Rapidly incorporate and adapt longstanding methods to the most recent FDA guidelines. Generate hypotheses and creative solutions to pursue Project goals, set new experimental directions, and overcome obstacles. Establish assay design criteria...

The Associate Director of GMP Operational Quality Assurance is an advanced technical resource and is recognized as an expert internally in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with all regulatory requirements. The Associate Director of Quality Assurance is responsible for oversight of multiple new product launches, ensuring effective alignment with business timelines and compliance with relevant global regulatory requirements. This role is expected to work closely with business partners and stakeholders to ensure successful market launch and expansion of existing brands...

Director, Engineering Operations (Cell and Genetic Therapies) The Director, Engineering Operations – CGT is responsible for building and leading the Engineering Operations team within the broader Biopharmaceutical Sciences – Cell & Gene Therapy (CGT) Manufacturing and Process Engineering organization. Vertex is rapidly progressing a pipeline of exciting cell and genetic therapy and biologics programs requiring development of sustainable and scalable clinical and commercial manufacturing capabilities across multiple sites in the Boston area. The Director is accountable for the full spectrum of engineering value-added services provided for site-based internal CGT manufacturing operations. Areas of responsibility include, but are not limited...

Vertex is a global biotechnology company on the forefront of scientific innovation. In addition to marketed therapies in cystic fibrosis (CF), sickle cell disease, beta-thalassemia, and moderate-to-severe acute pain , our research pipeline spans more than a dozen programs targeting the underlying mechanisms of serious diseases. Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group based in Boston's Seaport District. The HEOR Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition for Vertex’s CF and early pipeline assets through each stage of...

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Director will lead HEOR strategies and execution of evidence generation that optimize the value proposition of Vertex’s povetacicept assets through each stage of development, including launch and post-launch phases. This position reports to the Senior Director Global HEOR Kidney. Key Duties and Responsibilities Serves as the HEOR povetacicept Lead focusing on pipeline indications pMN and/or gMG Develops the HEOR strategy for povetacicept from early development through product lifecycle Serves as HEOR lead...

The Health Economics & Outcomes Research Associate Director will participate in leading the development and execution of Health economics and outcomes research studies in support of Vertex's products. Key Duties and Responsibilities Leads others to execute complex HEOR evidence generation including, cost-effective analysis and budget impact models, prospective and retrospective observational studies, ITCs, meta-analyses and systematic reviews, patient reported outcomes measure development and validation and other research as needed to support the asset value Gathers and synthesizes insights from Payers, KOLs and HEOR experts; stays current with scientific and policy trends and best practices and applies strategic and content expertise...

We are seeking a strategic, influential, and visionary HR Business Partner Senior Director to lead talent strategies for Vertex’s Cell & Genetic Therapies Research site and Research organization s during a transformative era of scientific innovation and organizational growth. This role will serve as a trusted advisor to Research Senior Vice Presidents and Vice Presidents and their leadership teams , shaping organizational design, culture, and workforce strategies that enable cutting-edge discovery and long-term scientific success. Reporting to the Lead HRBP for the Chief Scientific and Global Research organization , this individual will sit on Research leadership teams and play a...

Vertex Pharmaceuticals is seeking a highly skilled and motivated Senior Research Scientist to join our Disease Modeling Group. In this role, you will be responsible for the development of engineered human cell models and their integration into drug discovery workflows, supporting translational relevance and enabling the advancement of Vertex’s pipeline. You will apply expertise in human cell biology, primary cell systems, iPSC technologies, and gene editing to develop robust in vitro disease models that support target validation, proof-of-concept studies, primary screening, selectivity and efficacy assessments, mechanism of action studies, and medicinal chemistry optimization. The ideal candidate brings strong technical depth,...

The Manufacturing Process & Technical Quality Associate Director is accountable for end-to-end technical quality oversight of cell and genetic program throughout clinical development, commercialization, product launch and post approval lifecycle management activities. This includes establishing relevant product quality standards for current or novel technologies, ensuring internal and cross-functional alignment with industry and regulatory expectations, and identifying product quality risks and mitigations throughout development for the assigned programs. The role will closely partner with operational stakeholders to participate in Cell & Genetic therapies projects and associated governance to meet business, regulatory and operational requirements. Key Duties and Responsibilities Lead and/or participate...

Do you thrive at the intersection of strategy and execution? At Vertex, we believe that talent strategy is business strategy. As the Associate Director, People Experience Advisors , you will lead a team of People Experience (PX) Advisors who partner with HRBPs and business leaders to shape workforce strategies that drive organizational health and performance. This is a unique opportunity to influence enterprise-wide initiatives, coach leaders, and deliver insights that make a measurable impact on our people and our business. The Associate Director, PX Advisors leads a team responsible for advising on workforce planning, organizational design, and talent strategies...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...