Vertex Job Trends

The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients. The Supervisor will work one of the following shifts Second Shift - Tuesday to Saturday, 230PM - 11PM Second Shift - Sunday to Thursday, 230PM - 11PM Key Duties and Responsibilities Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards....

The Manufacturing Operations Supervisor is a critical first-line leadership role within Cell Manufacturing. This position is responsible for direct management of personnel executing GMP cell processing operations for adherent and suspension cell cultures. The candidate will have strong leadership skills, GMP expertise, and commitment to patients. The Supervisor will work one of the following shifts Second Shift - Tuesday to Saturday, 230PM - 11PM Second Shift - Sunday to Thursday, 230PM - 11PM Key Duties and Responsibilities Builds and develops an efficient team of 2-8 direct reports capable of consistently producing clinical cellular product or intermediates according to cGMP standards....

The Regional Field Leader, Associate Director will be responsible for the oversight of one of the eighteen geographic regions across three area teams for the US Pain Business Unit, which is preparing for potential commercialization of an investigational novel selective inhibitor of NaV1.8 in acute pain. We are looking for candidates with a strong track record of delivering exceptional results, establishing a strong team culture that aligns with Vertex values, and developing deep strategic account relationships. Regional Leaders will lead a team of 8-10 pain territory account managers and report into one of our three Area Field Leaders, Senior Directors....

Vertex is seeking a talented Research Scientist to join a collaborative research team focused on Biologics discovery and optimization in Boston, MA. The group’s mission is to deliver next generation biologics and genetic therapies impacting several therapeutic areas. We are looking for a candidate with a strong desire to deliver innovative new medicines to patients in need. In this lab-based role , the ideal candidate is strongly experienced in LC-MS based analytical method development and characterization of biologics including antibodies and antibody-like scaffolds, bioconjugates, and lipid nanoparticles. The candidate should be independent, accustomed to taking initiative, and bring enthusiasm and...

The Principal Scientist Aseptic Control is recognized as having expertise in the principals and application of sterile and low bioburden processing technologies and providing technical support for manufacturing of cell and gene therapy (C>), small molecule, and combination medical device programs within cCMP manufacturing. This aseptic processing SME will partner with stakeholders to define strategies for microbial control of activities such as gowning, facility monitoring programs (EM, Water, Gases, etc.), disinfectant efficacy, aseptic processing simulations, filtration, particulate control, risk assessments, and will ensure the control strategies comply with industry guidance. The individual will interface with internal and external manufacturing sites...

The Senior Medical Science Liaison (Sr MSL) will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide the...

The Senior Manager, Manufacturing Operations manages a supervisory team and provides oversight to the day-to-day operations. This position provides strategic and operational leadership to ensure safe, compliant, and efficient execution of cGMP manufacturing operations in alignment with production schedules, site objectives, and business priorities. The Senior Manager is accountable for maintaining an audit-ready facility, driving continuous improvement, building organizational capability, and supporting the successful production of pharmaceutical drug products. Key Duties and Responsibilities Manage and develop a supervisory team, ensuring strong execution, accountability, and team effectiveness. Direct the activities of the group through management of staff, prioritization, and assignment of...

At Vertex, we continue to invest in a future-ready workforce where AI helps people strengthen expertise, improve decision-making, and create greater impact for our people and patients. We are looking for an Associate Director, Workforce Intelligence to be the analytical and research engine behind how we plan our workforce, redesign work with AI, and make trusted workforce data easy for leaders to reach and act on. The role reports to the Senior Director of People Data, Analytics, & Technology and is fully dedicated to the Workforce Strategy & Innovation function, which spans workforce planning, Human-AI organizational design, and AI learning...

Role Summary Vertex is seeking a highly motivated Senior Research Scientist, Molecular & Cell Biology to join the Human Cell Models group in Boston Research. In this role, you will develop, characterize, and apply physiologically relevant human cellular models using stem cells and primary cells to deepen understanding of disease biology, identify therapeutic opportunities, and support the advancement of novel drug discovery programs. The successful candidate will bring deep expertise in disease modeling, with particular strength in neuronal model development using induced pluripotent stem cells (iPSC) and/or primary cells. This individual will have demonstrated experience developing neuronal models (i.e. dopaminergic...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Manager, Quality Control is a key position that provides oversight of a variety of analytical functions that occur across the Vertex Manufacturing Center (VMC) and Leiden Center (LC1) supporting testing, and reporting of in-process, release, and stability samples. This role also ensures activities occur in an efficient and cGMP compliant manner. The role is a third shift position, Wednesday through Saturday, and will have formal people management responsibilities. Work shift Wednesday to Saturday, 10 hour night shift between the hours of 900pm to 900am Key Duties and Responsibilities Independently manages a variety of laboratory program(s)/processes within the department (assay...

The Director will be responsible for building, maintaining, and continuously evolving Vertex’s Kidney forecasting capabilities across multiple assets and disease areas. This includes leading the development of robust forecast models, refining forecast logic and assumptions, and ensuring models remain responsive to new data, emerging insights, market events, and changes in program strategy. This leader will provide strategic forecasting and analytical support for key business questions, commercialization decisions, and portfolio planning needs. As a senior partner to Marketing, Commercial Strategy, Finance, Market Access, Medical, and other cross-functional stakeholders, the Director will bring objective perspective, strong business judgment, and deep forecasting expertise...

Vertex is seeking a talented individual to join our Analytical Development group in Boston, MA. As a member of an industry leading CMC team, this individual will help advance transformative medicines treating the underlying cause of serious diseases by conducting analytical chemistry activities for small molecule development programs. Responsibilities include characterization and stability assessment of drug substances, spray-dried dispersions, and drug products, as well as contributing scientifically to the resolution of broader drug development challenges in collaboration with other R&D functions. Expertise with laboratory techniques commonly used in the analysis of pharmaceutical products, including liquid chromatography (LC), is desired. Key...

Role Summary The High Throughput Human Biology group is seeking a highly motivated Research Scientist to support discovery programs through the development and implementation of innovative human biology assays. Working in a collaborative, multidisciplinary environment, the successful candidate will draw on expertise in cellular and molecular biology, laboratory automation, and data analysis to develop in vitro assays spanning multiple levels of biological complexity and define their application within high-throughput screening strategies. The successful candidate will also evaluate and incorporate emerging technologies, establish scalable experimental workflows, and partner across disciplines to translate scientific needs into robust solutions. They will leverage AI-enabled...

GENERAL POSITION SUMMARY The Global Patient Safety (GPS) Pharmacovigilance Science (PVSci) Manager leads assigned activities related to cross-functional safety data monitoring, assessment, and aggregate reporting to regulatory agencies, and support signal and risk management activities. KEY RESPONSIBILITIES Leads PVSci activities for assigned Vertex product, including coordinating review of emerging safety data and ensuring timely identification and communication of any potential safety issues Prepares aggregate safety report content, including risk management plans and responses to regulatory authority requests Conducts signal detection/tracking and other assessments/risk management activities Provides project management support for PVSci deliverables by establishing and managing timelines, content planning and...

The Associate Director, Global Pain Forecasting & Analytics will join the Global Forecasting & Analytics team within the Commercial organization to lead forecasting and analytics for Vertex’s global Pain portfolio, spanning current programs and future pipeline assets. This role will serve as a key partner to the Global Pain Marketing Lead and Global Commercial Strategy, leading the development and evolution of forecast models that support long-range planning, near-term operations, commercialization decisions, and cross-functional alignment across Pain disease areas. The Associate Director will build, maintain, and continuously evolve Vertex’s global Pain forecasting capabilities. This includes developing a deep understanding of the...

The High Throughput Biology Senior Research Scientist is responsible for experimental productivity and emerging creativity and versatility. The Senior Research Scientist designs and executes experiments for major research projects. These may include the development of cells and prosecution of biochemical and cellular assays for small molecule hit finding campaigns. Demonstrates resourcefulness in running multiple activities concurrently, all related to achievement of goals/ objectives. Adapts to new projects rapidly and to multiple projects effectively ensuring alignment with corporate goals. The Senior Research Scientist commands a deep understand of specialized discipline(s) and possesses diverse project experience and a broad panorama of (relevant)...

This role will cover the territory of Grand Rapids, Michigan area, which includes Kalamazoo, Lansing, Muskegon, Holland, Wyoming, Battle Creek and Jackson. The preferred candidate will reside within the surrounding areas of this territory. The Kidney Territory Account Manager (KTAM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs), developing a strategic business plan, communicating thorough disease and product knowledge to HCPs and centers of care. This role must understand market dynamics in rare, complex disease states, demonstrate excellent judgment, and be motivated by the desire to improve patients' lives. The KTAM will report into a...

The Associate Director, Speaker Bureau Content & Execution, US Kidney will support development and execution of peer-to-peer educational content across the US Kidney franchise, with initial emphasis on AMKD. This role reports to the Director, Speaker Bureau and Content Lead, US Kidney and ensures the franchise has high-quality, strategically aligned content to support current and future educational initiatives. The Associate Director will initially focus on content development, agency coordination, review/approval support, and executional pull-through for AMKD, with support for IgAN and POVE as needed. Over time, the role may expand to include speaker training logistics, speaker readiness, field enablement, and...

The Senior Biostatistician II will perform scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with guidance and mentoring on new and complex issues. The incumbent will complete assigned work in a resourceful manner and create alternative approaches to achieve desired results. The incumbent will develop a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Within assigned area, designs, develops and executes the technical/statistical infrastructure for the conduct and evaluation of clinical trials, observational studies, or real world data (RWD) investigations, including related areas/activities. Participates...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Role Summary The Automation Engineer supports management and implementation of control systems for equipment in a GMP manufacturing facility. This role supports equipment upgrades, troubleshooting, lifecycle planning, and compliant system operation as well as configuration for network integration and data historian management. The engineer provides day-to-day technical direction to contractors and works closely with Manufacturing, Engineering, Quality, Validation, and vendors. Key Responsibilities Support automation upgrades and modifications for data integrity and reliability improvements for manufacturing equipment. Configure, troubleshoot, test, and maintain PLCs, HMIs, industrial networks, and related automation components. Maintain OT asset inventories, software versions, patching records, and equipment lifecycle...

General/ The Investigator Sponsored Studies (ISS) Associate Director is responsible for overseeing the systems, processes, and daily operations of the ISS operations program in Medical Affairs. This position will provide direction and oversight of the ISS process to ensure all requests are reviewed in compliance with all external regulations, industry guidelines, and Vertex policies. Key Duties and Responsibilities Lead the ISS and research collaboration programs, including overall strategy, process enhancements, and day-to-day management, while ensuring compliance with Vertex policies across disease areas Manages the strategy and areas of interest development for each disease area during the annual medical planning...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The GxP Operations Support Specialist will support the implementation, maintenance, and continuous improvement of digital manufacturing systems. Working under the guidance of more senior team members, this role will partner with Manufacturing, Quality, Engineering, and IT stakeholders to document business processes, support system enhancements, test system changes, and help ensure reliable and compliant system operations. Key Duties and Responsibilities Help configure, test, and deploy MES and other system changes under the direction of senior team members, system owners, and technical teams. Participate in workshops and meetings with Manufacturing, Quality, Engineering, Supply Chain, and IT stakeholders. Support user acceptance testing (UAT),...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Vertex is seeking a highly motivated Stem Cell Research Scientist to join our research organization and advance innovative therapeutic approaches for type 1 diabetes (T1D). In this role, you will contribute to the discovery and development of cell-based therapies by applying expertise in stem cell biology, islet differentiation, cellular assay development, and translational research. The ideal candidate will bring strong technical depth in pluripotent stem cell culture and differentiation, experimental design, and functional characterization of stem cell-derived models, along with a passion for translating cutting-edge science into meaningful therapies for patients. This scientist will work closely with cross-functional partners across...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Director of Kidney Analytics will provide advanced analytics and data science leadership for strategic commercial initiatives across the U.S. Kidney therapeutic area. This role will use sophisticated analytical, statistical, and data science methods to identify and quantify market drivers, barriers, risks, and opportunities. The Associate Director will lead the development of scalable data products, analytical models, dashboards, and reporting solutions that enable data-driven decision-making across the Kidney business. The ideal candidate combines deep commercial analytics expertise with strong technical and data science capabilities. They will be able to work with large, complex datasets; develop fit-for-purpose models; communicate technical findings clearly;...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Facilities Maintenance Technician performs daily work supporting building operations and maintenance (plumbing, electrical, carpentry, HVAC). This role is expected to monitor the building management system software, and triage and respond to incidents and alarms, conduct facility walks to identify and correct issues, perform maintenance or repair of facilities equipment, install lab gases and/or connections, support space planning and furniture installations, and all other tasks and duties as assigned with minimal supervision. Professional in appearance and the ability to communicate clearly verbally and in writing. The Facilities Operations Technician performs repairs and maintenance to building equipment, machinery, and prepares or...

The MS&T Senior Scientist exercises a high level of experimental productivity contributing to the advancement of projects in pharmaceutical development or commercial manufacturing and may be running chemistry on multiple projects concurrently. This role requires bench chemistry as well as the management of projects, including roles on cross-functional project teams representing MS&T. This role will interpret complex chemistry, may champion new technologies and involve an increasing knowledge of related scientific disciplines, including regulatory and quality compliance. Cross functional association with Analytical Sciences & Technology (AS&T) Supply Chain management (SCM), Quality (QA) and Regulatory is expected, along with change management activities....

The Senior Director, Marketing is accountable for understanding the market landscape and Vertex's position within the market, actively contributing to defining the strategic and performance goals of the portfolio, and tracking performance against those goals. As a people manager, this role may have financial accountabilities and human resource responsibilities for assigned staff. Key Duties and Responsibilities Develops the portfolio strategy, and oversees creation of brand strategies and brand lifecycle activities Oversees development and implementation of strategic and tactical plans for brand Leads team through challenges related to creating external (promotional) communications materials for external use with customers Provides input into...

The Commercial Training Associate Director will be part of the Global Commercial Excellence team and contribute to the development of a marketing competency model, overall marketing excellence, change management initiatives, and innovation. Key Duties and Responsibilities Drives the organizational adoption of the Marketing Competency Model Leads the communication plan and channels in the roll out Works with and influences senior commercial leaders to ensure a consistent message and usage Establishes metrics for what a successful adoption of the competency model entails both globally and locally Works with Learning and Development business partners to ensure the competency model is included in...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

Vertex Pharmaceuticals is a global biotechnology leader committed to scientific innovation and the development of transformative medicines for people with serious diseases. Our finance function is a strategic enabler of Vertex's mission — providing the insights, rigor, and partnership that drive high-quality decisions across the enterprise. This is a high-visibility, high-impact role at the frontier of science and finance — where your work directly shapes how Vertex invests in advancing its pipeline from target identification through candidate nomination and beyond. We are seeking a strategic finance leader to serve as Director, R&D Finance, acting as the primary finance partner to...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Associate Director, GMP Operational Quality is responsible for oversight of team activities, development of personnel and ensuring quality of deliverables within department purview. The incumbent has comprehensive knowledge of principles and application of quality assurance and compliance. The incumbent is responsible for development of group goals and projects ensuring alignment with corporate goals and compliance with all regulatory requirements, refining goals and projects when necessary. The incumbent not only coordinates group responsibilities to ensure timely delivery to support business, but mentors team members to provide individual development in addition to efficient and valuable service to project teams. Key Duties...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Executive Director, Commercial Analytics leads the Commercial Analytics Center of Excellence within US Commercial, providing enterprise-level oversight across forecasting, performance and strategic analytics, sub-national and field analytics, omnichannel and media analytics, and market research across North America, Global, and Early Pipeline. This role is a senior strategic partner to Commercial leadership and is accountable for elevating analytics from a tactical service into a core commercial capability that enables executive decision-making, launch excellence, and optimized investment. Key Duties and Responsibilities Lead the Commercial Analytics (CA) COE, overseeing ~20-25 FTEs organized by disease area (DA) verticals. Define enterprise analytics vision, operating...

Vertex is seeking a Senior Director, Global Commercial – Pain to play a key leadership role in shaping the global commercial strategy for our pain portfolio, with a strong focus on acute pain. This individual will lead critical strategic efforts across commercial opportunity assessment, long-range forecasting, target product profile development, and brand strategy. The successful candidate will bring deep expertise in market and customer insights, a strong understanding of the acute pain landscape, and the ability to translate complex market dynamics into clear, actionable commercial strategies. This role requires a highly strategic, collaborative leader who can work effectively across functions...

Vertex is seeking a talented individual to join the Engineering and Materials Science (EMS) department in Boston, MA. The successful candidate will be productive, results-oriented, and able to lead a diverse team of engineers and scientists to contribute to the successful development and scale-up of drug substance processes. Excellent interpersonal and organization skills as well as a high level of technical aptitude and creativity are required for success in this position. Key Duties and Responsibilities Responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of...

The Biostatistics Associate Director will perform sophisticated scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with minimal guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent is capable of independent strategic and technical contributions. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Conducts all scientific and operational statistical work for multiple clinical trials, observational studies, or real world data...

The Clinical Development Medical Director will serve as the Medical Lead for Vertex clinical trials, working with cross-functional multidisciplinary study teams on clinical trial strategy, design and execution and serving as the Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. The incumbent will work on multiple trials in all Phases of clinical development, and may also participate in other selected projects in clinical development. Key Duties and Responsibilities Leads the development of Study Protocols, Investigator Brochures, Clinical Development Plans and other key study documents in conjunction with other line functions and with minimal guidance Serves...

Senior Director, Regulatory Transformation & Innovation Job Summary The Senior Director, Regulatory Transformation & Innovation is a strategic leadership role within Regulatory Operations responsible for driving the implementation of transformation initiatives across Global Regulatory Affairs (GRA). This Senior Director will define and execute a transformation and innovation strategy that modernizes GRA-related processes by enabling new ways of working through application of digitization, AI/ML, analytics, automation, and technology solutions. Working across GRA and cross-functional partners, the Senior Director will identify, prioritize, and implement opportunities to enhance organizational effectiveness and drive business value, including through innovative approaches to regulatory document development, knowledge...

Vertex’s Automation of Machinery and Process (AMP) Team is seeking a Principal Process Engineer to develop cutting-edge manufacturing solutions for its Cell & Genetic Therapies programs. This pivotal role is at the forefront of automating complex processes in one of the most dynamic and rapidly evolving fields in biotechnology. You will work with a passionate team of engineers, scientists, and innovators united by a shared mission to push the boundaries of what’s possible in Cell & Genetic Therapy. This position plays a critical role in leading cross-functional workstreams for equipment & systems development, process optimization, and technology transfer to deliver...

The Senior Scientist, Analytical Sciences & Technology (AS&T), plays a critical role in the Commercial Manufacturing & Supply Chain team. You will be responsible for providing strong expertise with biological assays and analytical requirements to ensure launch readiness and lifecycle management for the commercial Cell and Gene therapy (CGT) portfolio. Key Duties and Responsibilities Accountable for the success of commercial analytical activities, prioritization, and execution to meet program commitments Subject Matter Expertise (SME) for ensuring the robustness of analytical methods and commercial testing requirements Author and/or review technical documents, including method SOP, study protocol and technical report Partners effectively with...

Vertex Pharmaceuticals is seeking a highly motivated Packaging and Labeling Manager to support its growing commercial portfolio and robust pipeline of development-stage products. This role is responsible for managing end-to-end pharmaceutical artwork development and implementation activities, ensuring packaging and labeling materials are developed, reviewed, approved, and implemented accurately and on schedule. The Packaging and Labeling Manager will collaborate extensively with cross-functional stakeholders, including Regulatory Labeling, Quality Assurance, Supply Chain, Manufacturing Science & Technology (MS&T), external graphics providers, and packaging sites worldwide. The ideal candidate is a collaborative leader with strong project management skills, extensive knowledge of pharmaceutical artwork processes, and...

The Process Development Engineering Principal Associate responsible for Manufacturing Science and Technology (MSAT) activities for cell therapy products. The candidate will provide cross-functional support in technology development and transfer from Development to Clinical Manufacturing and Process Performance Qualification including internal operations and potentially various CDMOs. They are also responsible for planning and implementing continuous improvement initiatives for life-cycle management working in cross-functional environment. Key Duties and Responsibilities Lead triage, investigation, and change control implementation as a Manufacturing Science and Technology functional area assessor and identify improvements, implement changes, and monitor clinical and commercial manufacturing processes. Manage the execution of deliverables,...

The GxP Site Engineering Senior Specialist will represent Global Engineering for Engineering needs from process, facility, instrumentation, and regulatory needs for Vertex GxP Facilities. The GxP Site Engineering Senior Specialist will collaborate with Facilities Operations, Advanced Manufacturing Engineering, Project Engineering, PMO, CMC teams and Site Leadership to meet all facility and manufacturing needs. This role will involve various aspects of equipment, and facility infrastructure-focused engineering efforts. Key Duties and Responsibilities Collaborate with scientific groups to learn and understand the evolving science and technology. Executes change management for facility and other support systems including commissioning and/or implementation of other related initiatives...

The Materials Management Warehouse Senior Specialist provides oversight to warehouse operations and inventory logistics for cell and gene therapy manufacturing sites located in Boston and Cambridge. This role provides leadership to managed service providers performing material receipt, inventory control, kitting, transport, and issuance of raw materials and components. Additionally, this role oversees the receipt, transfer, storage, and pack-out of drug product. The Materials Management Specialist serves as a subject matter expert (SME) for Materials Management, serving as department liaison for scheduling, escalations, and quality events. 2nd Shift Monday - Friday 230pm -1100pm Key Duties and Responsibilities Subject Matter Expert (SME)...

MBA Summer Associate, Commercial The Vertex MBA Summer Associate Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are fearless" is in everything we do. Each summer, top MBA candidates from business schools around the world find all this and more through our MBA...

The Regulatory Labeling Associate Director will be responsible for strategic labeling and for executing on one or more products either at the global label-level (CCDS, USPI, EuSmPC) or in multiple ROW countries/regions for a given therapeutic area. This role may be accountable/responsible for specific business processes and may also be responsible for the development and management of a TLP with some guidance. Key Duties and Responsibilities Ensures compliance with labeling governance requirements and associated business processes. Leads label working groups and representing labeling at senior labeling governance meetings. Develops and maintains global product labeling for one or more products. This...

MBA Summer Associate Intern, Finance The Vertex MBA Summer Associate Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are fearless" is in everything we do. Each summer, top MBA candidates from business schools around the world find all this and more through our...

The Associate Director of GMP Operational Quality Assurance is an advanced technical resource and is recognized as an expert internally in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with all regulatory requirements. The Associate Director of Quality Assurance is responsible for oversight of multiple Validation projects associated with Product Launch and Continuous Improvements, ensuring effective alignment with business timelines and compliance with relevant global regulatory requirements. This role is expected to work closely with business partners and stakeholders to ensure successful project...

The Materials Management Warehouse Senior Specialist provides oversight to warehouse operations and inventory logistics for cell and gene therapy manufacturing sites located in Boston and Cambridge. This role provides leadership to managed service providers performing material receipt, inventory control, kitting, transport, and issuance of raw materials and components. Additionally, this role oversees the receipt, transfer, storage, and pack-out of drug product. The Materials Management Specialist serves as a subject matter expert (SME) for Materials Management, serving as department liaison for scheduling, escalations, and quality events. 2 Shifts available Wednesday - Saturday 500am - 330pm or Sunday - Wednesday 500am -...

Overview The Revenue Accounting Manager will be responsible for overseeing the accounting for the order-to-cash process and the delivery of accurate and timely financial information relating to certain product revenues (including cell and gene therapies), gross to net accounts and accounts receivable to meet the operational needs and internal and external reporting requirements of the organization. The role will partner closely with members of Trade and Distribution, Market Access, Finance, Global Revenue Accounting, Government Pricing and Third-Party Partners. The Manager will also be responsible for identifying and driving process improvement initiatives including automation and data analytics. Key Duties & Responsibilities...

Vertex is seeking a Media and Buffer Preparation Supervisor to support media development and cell therapy manufacturing activities in Boston, MA. This role leads daily media, buffer, and stock solution preparation operations; ensures reliable, high-quality, and GMP-ready execution; and develops a strong, accountable team. The Supervisor will partner with cross-functional teams to improve processes, support scale-up and manufacturing readiness, and advance automation and continuous-improvement initiatives. Key Duties and Responsibilities Supervise daily media, buffer, and stock solution preparation, including scheduling, prioritization, troubleshooting, and escalation of issues. Lead, coach, train, and develop team members to strengthen technical skills, accountability, and operational discipline....

Vertex is seeking a talented individual to join our Process Development team as a Senior Scientist. The primary focus of this role is to lead the execution of process development and engineering studies for a cell-based drug candidate designed to treat diabetes. The Senior Scientist will be responsible for internal process development work, including process robustness and characterization studies, and may support manufacturing investigations. Importantly, the Senior Scientist will lead a weekend shift team to provide continuity for on-going studies over weekends and holidays. This is a full-time weekend and holiday shift position based in our Boston, MA facilities. The...