Vertex Job Trends

Vertex is seeking an experienced commercial leader to implement field sales and non-personal promotion tactics in support of the Pain Business Unit (BU). The Customer Strategy & Execution Lead (CSEL) will partner with North America commercial organization to implement the go-to-market (GTM) strategy and deliver customer solutions that meet the business needs. This role will work directly with the BU stakeholders, Field Operations Leads, Digital Operations Leads, Customer Data Management, and technical stakeholders to optimize HCP customer experience. This role reports to the Director, Customer Strategy & Execution Lead. Key Duties and Responsibilities Partner with key business leaders to understand...

The Commercial Data Management Senior Manager, CF/Kidney, is responsible for contributing to the coordination, design and delivery of the commercial data activities that enhance customer engagement and facilitate data driven decision making for the Cystic Fibrosis (CF) and Kidney therapy business units. Key Duties and Responsibilities Acts as an advisor and coach for and collaborates with the governance team(s) Creates and monitors data quality scorecards in collaboration with Patient Services and Trade team partners Manages data services vendors Supports the training of internal teams on processes and procedures, including CRM Collaborates with Global Information Systems (GIS) team regarding implementation of...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Medical Affairs Strategy Medical Director will provide medical leadership for the Povetacicept programs. Povetacicept (pove) is an enhanced, dual BAFF/APRIL inhibitor in pivotal development for the treatment of IgA Nephropathy (IgAN), that has best-in-class and pipeline-in-a-product potential across a variety of autoimmune diseases. This role will be responsible for developing the medical strategy and medical plan under the direction of the VP/Executive Director, as well as executing against the medical plan encompassing the pove programs. This role will collaborate closely with cross-functional groups to ensure that scientific and medical strategies are aligned with broader corporate and key stakeholder needs,...

The Executive Director (ED), North America Commercial Operations leads a team that supports multiple in-line disease areas, supporting each US Business Unit and their respective leadership teams within North America Commercial. The ED oversees 5 district functions Commercial Data Management, Field Operations, Marketing Operations, Field Training, and Business Engagement Leads. This position reports to the Vice President, North America Commercial Operations, Insights & Analytics and is located at our headquarters in Boston, MA in the Seaport area. Key Duties and Responsibilities Leads 5 distinct functions Commercial Data Management, Field Operations, Marketing Operations, Field Training, and business engagement leads in support...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Commercial Data Management Senior Manager, Pain, is responsible for contributing to the coordination, design and delivery of the commercial data activities that enhance customer engagement and facilitate data driven decision making for the Pain therapy business unit. Key Duties and Responsibilities Acts as an advisor and coach for and collaborates with the governance team(s) Manages data services vendors Supports the training of internal teams on processes and procedures, including CRM Collaborates with Global Information Systems (GIS) team regarding implementation of fixes and enhancements Partners with Sales and Marketing teams to manage and administer content update requests Manages HCP-to-HCO affiliations...

We are seeking an innovative and highly motivated Senior Scientist to lead discovery-stage development of targeted lipid nanoparticle (LNP) platforms. This role will drive receptor target identification and validation, establish high-throughput ligand conjugation workflows, and develop scalable assay systems to enable systematic screening of targeted LNP constructs. The successful candidate will build a modular, data-driven targeting engine capable of evaluating single and multi-ligand strategies across multiple cell types and therapeutic indications. This is an onsite position in San Diego. KEY RESPONSIBILITIES Receptor Target Identification & Validation Identify and prioritize cell-surface receptor targets aligned with disease biology and delivery feasibility. Integrate...

Vertex

The Senior Administrative Assistant provides experienced office/business support to a department. The Senior Administrative Assistant generally reports directly to a(n) Country Manager, Executive Director or Vice President-level manager. Key Duties and Responsibilities Manages calendars for assigned personnel, including meeting scheduling (both internal and off-site meetings), accepting/declining invites, meeting prioritization, securing conference rooms, ordering catering and "day-of" logistical and administrative support Serves as a departmental resource for Vertex's internal technologies (i.e; Procurement, SharePoint, Concur, Vertex U, VLearn, etc.) Exchanges and integrates information from stakeholders into departmental reports Books flights/hotels, completes expense reports, and arranges team lunches/dinners and offsite meetings for assigned...

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Senior Manager will participate in the development and execution of Health economics and outcomes research studies in support of Vertex's products. This position reports to the Director HEOR, Pain. Key Duties and Responsibilities Executes HEOR evidence generation including, cost-effective analysis and budget impact models, prospective and retrospective observational studies, ITCs, meta-analyses and systematic reviews, patient reported outcomes measure development and validation and other research as needed to support the asset value Provides...

The Senior Administrative Assistant provides experienced business support to the Quality department, reporting directly to a Vice President. The role is responsible for core administrative duties including calendar management, budget planning, and partnering with other assistants to drive continuous improvement. A primary focus of this position is establishing and leveraging digital technologies and AI to enhance task execution and optimize departmental workflows. Key Duties and Responsibilities Ensures seamless execution of day-to-day activities including proactive calendar management, meeting prioritization, and logistical support. Serves as a departmental resource for internal technologies such as SharePoint, Procurement, and Concur. Books travel logistics and completes...

The Document Manager will be part of the Program Quality Team in Vertex’s North America Commercial Patient Support Program Center of Excellence (NAC PSP COE). Reporting to the Senior Document Manager, the Document Manager will play a crucial role within the COE Program Quality Team and contribute to the NAC PSP success through document/knowledge management This role is responsible for supporting disease area Patient Support Programs (PSPs) in the strategy, development, and revision of program documents including standard operating procedures (SOPs) and work instructions (WIs) in collaboration with multiple stakeholders Key Responsibilities Responsible for effectively managing a robust collection of...

The Patient Safety Associate Medical Director will provide medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development). This role will optimizes patient safety of Vertex products and maintenance of compliance with the Pharmacovigilance regulations of Regulatory Agencies around the globe, through the effective and timely completion of Safety activities through the product life cycle. Key Duties and Responsibilities Provides medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development) Responsible for the safety assessment activities of assigned products under the supervision...

Reporting to the Senior Director, Contract Operations, this role is responsible for the lifecycle management process of agreements within the US Market Access Organization (Commercial and Government (ex Medicare Advantage and Part D)) Full Line Wholesalers, Specialty Distributors, Specialty Pharmacies, Group Purchasing Organizations, PBMs, and other segments and channels as required. This position will work closely with the Senior Director, Contract Operations and cross-functional leaders to ensure agreements meet business, legal, operational and compliance needs across several therapeutic areas. The ideal candidate will be familiar with and highly conversant in various segments of market access, discuss and incorporate contracting strategies...

The Director, Congress, Ad Board, and Strategic Council Lead, US Kidney is responsible for setting the strategic direction, planning, and flawless execution of congresses, advisory boards, and strategic councils for povetacicept and inaxaplin to support our launches in IgA nephropathy (IgAN) and APOL1-mediated kidney disease (AMKD). This leader will define and oversee the immediate and long-term vision for the company’s presence and influence across 50 regional and national conferences, ensuring alignment with the overall brand strategy and business objectives. Additionally, this person will be responsible for engaging with Key Thought Leaders (KTLs) to plan and execute high-impact ad boards and...

Vertex Pharmaceuticals is seeking a highly skilled and motivated Senior Scientist in Bioanalysis to join our dynamic team. The successful candidate will play a pivotal role in designing, executing, and interpreting complex bioanalytical experiments to support our innovative small molecule research and development programs. This position requires a deep understanding of LC-MS and related sample preparation techniques, a strong ability to manage multiple projects, and a commitment to advancing scientific discovery in alignment with Vertex’s mission. Key Duties and Responsibilities Design and execute technically challenging LC-MS-based bioanalytical experiments to support small molecule drug discovery and development. Analyze and interpret complex,...

We are seeking a visionary People Research Associate Director to lead the design and execution of high-impact research initiatives that shape workforce strategy and elevate organizational effectiveness. This role demands deep expertise in experimental methods, program evaluation, and storytelling with data. The People Research Associate Director will hold a PhD in a relevant field and bring a strong track record of translating complex research into actionable insights for senior leadership. Key Duties and Responsibilities Lead End-to-End Research Design Architect and execute research studies to evaluate the effectiveness of HR programs, policies, and interventions. Plan, design and conduct experiments to understand...

Vertex Pharmaceuticals, Inc. is seeking a highly skilled and proactive Principal Research Associate to join our Human Cell Core, contributing to the development and execution of advanced human cell models at scale. The ideal candidate is an expert experimentalist who excels in a fast paced , team-oriented environment and operates with a high level of scientific rigor and independence. This role involves maintaining and expanding primary human cells at scale, operating automation-enabled cell culture platforms and executing functional assays to support cell optimization and troubleshooting efforts. Success in this position requires exceptional reliability, attention to detail, adaptability, problem solving skills...

The Senior Manager, GxP Strategic Training Partner (STP) serves as a dedicated strategic partner to assigned operational or functional business areas, responsible for translating business needs and regulatory expectations into effective, practical, and inspection-ready learning solutions. This role operates as part of a Strategic Training Partner (STP) model led by the Associate Director, GxP Training & Learning Strategy. STPs are expected to be experts in adult learning and deeply knowledgeable in the business areas they support, enabling them to diagnose needs, challenge assumptions, and design learning approaches that improve execution—not just training completion. The STP is accountable for shaping learning...

The Senior Quality Manager will be part of the Program Quality Team in Vertex’s North America Commercial Patient Support Program Center of Excellence (NAC PSP COE). The COE is a group of compassionate and determined individuals who provide operational support to our commercial Patient Support Programs (Cystic Fibrosis, Hematology, Diabetes and Kidney) in areas such as systems and technology, data and analytics, vendor management and program quality. Additionally, COE team members help design patient support offerings and policies for future Vertex Patient Support Programs (PSP). The Senior Quality Manager will play a meaningful role within the COE and contribute to...

The Clinical Pharmacology Director leads strategic, scientific and operational aspects at a program level. This role represents the department on strategic and operational cross-functional program teams and will be responsible for the development of clinical pharmacology plans; assists in departmental management through program reviews and collaborative decision-making; supervises asset leads, provides career development; routinely co-leads cross-functional efforts and leads department initiatives. Key Duties and Responsibilities Responsible for the application of clinical quantitative pharmacology strategy to support the immunology portfolio. Guides metabolic, co-dosing and drug-drug interaction issues, collaborating closely with cross functional colleagues. Co-leads or serves on cross-functional committees and/or contributes...

The Associate Director, Marketing Operations – Speaker, Exhibit, and Sponsorship Platform role serves as the strategic lead for North American commercial peer-to-peer programming and congress exhibit, sponsorship activities. Overseeing effective healthcare professional engagement in support of business unit objectives. Establishing capabilities and process to manage the end-to-end speaker lifecycle, contracting, and payment reconciliation for exhibits, sponsorships, and memberships. This role bridges brand objectives with operational excellence to accelerate education while maintaining adherence to global compliance requirements. Key Duties and Responsibilities Speaker Lifecycle & Contract Management Lead the execution and resolution process for a business unit speaker contracts and manage the...

Position Overview The Payer Account Director–Government Accounts (PAD-GA) leads national payer and PBM strategies to secure optimal access and reimbursement for Vertex’s commercialized products in Federal and State Medicaid channels. This includes ensuring appropriate pharmacy and medical benefit policies, building relationships with key decision-makers, negotiating contracts, and aligning Vertex’s value with payer priorities. As the primary contact for assigned national accounts, the PAD-GA drives market access, supports sales across Business Units, and ensures strategic alignment to improve patient access and brand performance. The role involves collaborating with Payer Account Associate Directors (PAADs) and Payer Account Directors (PADs) to develop and...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

Company Overview Vertex is growing at a rapid pace with exciting opportunities for motivated professionals who want to contribute to our mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our Finance function plays a critical role in delivering on this mission by shaping strategy, enabling informed decision making, and providing deep business insight to support value creation across the enterprise. The Senior Director of Commercial Finance is a senior leader within the US Commercial Finance organization and serves as the primary strategic business partner to the U S Commercial Vice President and...

The External Manufacturing Associate Director role is a key member of Vertex’s External Manufacturing Organization (ExM), providing support, strategic insights and enterprise thinking to the Biopharmaceutical Sciences and Manufacturing Operations organization (BSMO). This leader will cultivate and leverage multiple cross-functional business relationships to identify and execute creative solutions to organizational opportunities and challenges. This role will be responsible for managing a subset of the Small Molecule Drug Product external network of Contract Manufacturing Organizations (CMOs). Key Duties and Responsibilities In partnership with Supply Chain, MSAT, Quality and Finance, develop external manufacturing production plans and drive plans to execution (on time...

Vertex is seeking a talented and experienced leader to join our Analytical Development Team to lead Biologic project CMC analytical development activities. The experienced leader will play a central role in advancing our biologics projects by executing development activities through a combined internal and external network. The individual is expected to closely work with external partners in developing and executing the development activities of biologics from the discovery interface to first license approval and beyond. The individual is expected to lead the execution of analytical activities according to phase appropriate development strategies. The successful candidate must work well in a...

The Quality Manager is an advanced technical resource in the principles and application of quality assurance and compliance. The Quality Manager coordinates or executes activities on multiple complex projects and takes a role in the design and execution of new projects. The Quality Manager adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with all regulatory requirements . Key Responsibilities The responsibilities of this position may include, but are not limited to, the following Participates in cross-functional teams as a Quality technical resource responsible for providing quality oversight and support to analytical testing at contracted...

The IT Audit Manager leads the planning, execution, and reporting of IT internal audits to evaluate the effectiveness of technology governance, risk management, and internal control practices. This role ensures continuous improvement of IT controls in alignment with organizational objectives and risk tolerance, regulatory requirements, and industry best practice frameworks. The role will have supervisory responsibility for audit staff supporting assigned audit engagements. This position requires a strong understanding of audit methodologies, risk management concepts, IT systems, cybersecurity, data privacy (GDPR), and relevant IT internal control frameworks (NIST-CSF, ITIL, COBIT, etc.). Key Duties and Responsibilities Responsible for successful end-to-end delivery...

The Senior Medical Science Liaison (Sr MSL) Pain will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide...

Vertex is seeking a talented leader to join our North America Commercial Operations team to support our growing portfolio of transformational therapies. This role will be part of the Digital Customer Engagement team that will support other core marketing technology platforms and will drive the evolution and implementation of our innovative go-to-market model that focuses on a lean in-person presence supplemented by robust digital engagement. This individual will will work with marketing teams to ensure our CDP & MA platforms deliver an optimized customer experience across the patients & healthcare professionals we seek to engage. We are seeking a candidate...

The Regulatory Strategy Manager will be responsible for regulatory support for development programs or marketed products. The Regulatory Strategy Manager will contribute to the development of US regional or global regulatory strategies for development and commercialization of program(s) within the portfolio. This role requires a good understanding of regulatory affairs frameworks, the drug development process, and related concepts. Key Duties and Responsibilities Contributes to the development and implementation of regulatory strategy for assigned region as a member of the global regulatory affairs functional team Develops proficiency in regional and global regulatory skills Supports global regulatory strategy under guidance of the...

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation and create transformative medicines for people with serious diseases. Our finance function is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. By joining our function, you will become part of a fast-moving, forward-thinking team to support the ongoing growth of a leader in the biotechnology industry. The Finance Manager of Clinical Development is a key member of Vertex's Finance business...

The DTE Marketing Technology team is playing a crucial role in enabling our commercial expansion as Vertex commercializes into new disease areas and brings more transformative medicines to patients around the world. As the Marketing Automation & Customer Data Platform Lead, you will be responsible for the administration, optimization, and oversight of our Salesforce Marketing Cloud, Marketo, Tealium and OneTrust platforms and the overall operations of this function. This is a critical platform function which drives the orchestration of all our digital customer experiences. As the platform and functional lead, you will be responsible for implementing new capabilities, driving solution...

The Health Economics & Outcomes Research Associate Director will participate in leading the development and execution of Health economics and outcomes research studies in support of Vertex's products. This position reports to the Director, HEOR Pain. Key Duties and Responsibilities Leads others to execute complex HEOR evidence generation including, cost-effective analysis and budget impact models, prospective and retrospective observational studies, ITCs, meta-analyses and systematic reviews, patient reported outcomes measure development and validation and other research as needed to support the asset value Gathers and synthesizes insights from Payers, KOLs and HEOR experts; stays current with scientific and policy trends and...