Vertex Job Trends

The Associate Director, Global Patient Safety (GPS) Individual Case Safety Report (ICSR) Therapeutic Area (TA) Lead is responsible for the oversight of global ICSR processing excellence and external business management within a specified TA. This position plans, executes and manages the technical aspects of Individual Case Safety Report (ICSR) processing and reporting, as well as provides oversight to external PV partners and vendors. GENERAL RESPONSIBILITIES AND REQUIRED SKILLS The Associate Director, Global Patient Safety ICSR TA Lead plays a key role in managing global ICSR processing excellence and external business management. This position serves as subject matter expert in global...

The Sr. Director, GCP Operational Quality will advance and provide strategic direction and oversight of the strategies, mechanisms, processes and capabilities for effective and proactive quality risk management across respective product/therapeutic program area(s) (e.g.; Cystic Fibrosis). This individual will serve as the GCP Operational Quality Lead and have overall responsibility for lifecycle review of risks to quality through ensuring appropriate oversight, mitigation strategies and plans enabling clinical quality outcomes and real time inspection readiness. This individual will provide strategic oversight and leadership for Quality Management Reviews, ensuring transparency for gaining insights regarding effectiveness of risk mitigation strategies/controls, proactive and sustainable...

Role Summary The Senior Manager, P2P Process & Platform Enablement is responsible for leading and advancing Procure-to-Pay (P2P) execution enablement, serving as a senior business lead for the platform, processes, and controls that support compliant, efficient purchasing and supplier transactions. This role leads the business-side enablement of P2P execution across requisitioning, approvals, catalogs, purchase orders, receiving, invoice processing and matching, and Supplier Information Management (SIM). The role helps ensure P2P execution is stable, well-controlled, scalable, and continuously improved, leveraging best in class practices and AI. Partners closely with Procurement Operations, Finance/AP, IT/Digital, and other COE towers to deliver reliable outcomes...

This role has overall accountability for strategic leadership and oversight of the end-to-end quality assurance strategy for proactive, risk-informed, and sustainable quality oversight and compliance with regulatory expectations across Vertex processes for clinical evidence generation and product vigilance. Responsibilities Serves as a strategic partner to functional leaders across product modalities responsible for Research (including both non-regulated and GLP work), Biomarker Development, and Diagnostics in assuring appropriate quality/compliance oversight of processes and systems supporting effective delivery of these programs and the rigor and integrity of associated data. Defines strategy for and oversees tactical execution strategic plan by direct reports...

Senior Director, Quality Data, Digital Systems & Compliance GxP Data Governance Data Integrity Master Data Computer Systems Assurance Quality Analytics General position summary The Senior Director, Quality Data, Digital Systems & Compliance, serves as a pivotal leader within the Quality organization. This role provides strategic vision and direction to advance frameworks, strengthen organizational capabilities, and scale models and operations across GxP Data Integrity, Data Governance, Quality Analytics, and Digital Systems Compliance (CSA/CSV) oversight. The position promotes leading practices, supports organizational growth, and enables adaptation to evolving industry expectations as well as advanced and emerging technologies. This...

Vertex’s Data, Technology and Engineering (DTE) organization is seeking a Director, AI Portfolio Management to join the Project Management and Strategic Operations (PMSO) team. PMSO is responsible for streamlining and simplifying the work of Vertex’s data and technology teams and supporting the successful deployment of new technologies across the global enterprise. This role reports to the Senior Director, Project Management and Strategic Operations and partners closely with the Chief Technology Officer (CTO) to oversee a portfolio of AI-driven initiatives supporting Vertex’s ambition of a tech-enabled workforce. The role requires leadership across portfolio planning, financial management, governance, and oversight of program,...

Vertex is seeking a Senior Director, Head of Quality Control to lead QC strategy and external laboratory oversight for our Type 1 Diabetes Cell Therapy external manufacturing network . This leader will be responsible for building and scaling a robust QC partnership model supporting complex stem cell-derived therapies across CDMOs, external testing laboratories, and commercial/clinical supply operations. This role is focused on QC network oversight , including outsourced testing governance, method transfer into external laboratories, QC scheduling and budgets, sample management strategy, assay readiness, analytical performance monitoring, and QC compliance across the external network. What You’ll Do Lead Quality Control...

Senior Director, Head of Technical Services, T1D Cell Therapy Manufacturing Operations Department Manufacturing Operations Reports To Vice President, Type 1 Diabetes Manufacturing Operations Location Boston, MA and Portsmouth, NH Work Model Full time on site or hybrid eligible Vertex is seeking a Senior Director, Head of Technical Services to lead manufacturing-facing technical support for our Type 1 Diabetes Stem Cell Therapy Manufacturing Operations organization. This leader will oversee real-time GMP manufacturing support, troubleshooting, investigation support, operational process monitoring, manufacturing readiness, and implementation of approved process changes. The role requires deep experience in cell therapy manufacturing, strong people leadership, and the...

The Senior Manager, Manufacturing Technical Operations (MTO), is responsible for developing and executing the quality-record strategy for quality events supporting internal Cell and Gene Therapy (CGT) manufacturing. The role provides end-to-end oversight of quality events, including corrective and preventive actions (CAPAs), change controls, deviations, and analytical investigations. Responsibilities include reviewing quality metrics and trends; escalating cross-functional risks and issues; and establishing operational excellence practices that strengthen quality event compliance, investigation quality, timely record closure, and the sustainable implementation of CAPAs and change controls. The Senior Manager partners closely with Manufacturing, Quality Assurance, and other cross-functional stakeholders to promote a quality...

The Business Engagement Lead role within DTE to support our Clinical Development and Early Development business function role serves as a strategic partner between the business and DTE, translating business priorities into scalable, compliant, and fit-for-purpose systems, processes, and digital solutions. The Associate Director will work closely with business leaders and subject matter experts to understand priorities, shape capability roadmaps including AI related business use cases, and drive delivery of solutions that improve how our development organizations work. This role requires strong relationship management, business process acumen, and the ability to lead across a complex, matrixed, and regulated environment. Key...

General/ The Director, Global Trade Compliance is responsible for developing, owning, maintaining, and executing global trade compliance business processes, global trade management systems, and associated regulatory compliance activities. This role supports all Vertex supply chain models—including finished goods distribution, commercial manufacturing, clinical materials, development, research shipments, and other cross-border movements—across all geographies in which Vertex operates. The Director leads the Global Trade Compliance (GTC) business process and regulatory compliance team, resolving operational challenges, advancing strategic solutions, and ensuring consistent, accurate, efficient, and compliant customs declarations and related activities that support Vertex and the patients we serve. Key Duties & Responsibilities...

Vertex Pharmaceuticals is seeking a Principal Scientist, Microbiology to join the Analytical Science & Technology (AS&T) organization supporting biologics, cell therapy, and gene therapy programs. This role serves as the microbiology technical leader and subject matter expert responsible for microbiological methods and microbial control strategies supporting late-stage development and commercial products. The successful candidate will provide scientific leadership across microbiology method lifecycle management, external laboratory oversight, investigations, compliance, and continuous improvement to ensure robust, inspection-ready testing throughout the global network. Key Duties and Responsibilities Lead microbiology method qualification, validation, transfer, implementation, monitoring, and lifecycle management activities supporting biologics, cell therapy,...

The Package Engineering Associate Director has an established track record of both technical and project leadership, exerting broad influence both within and outside the Technical Operations organization. This role is accountable for effectively managing overall relationships with key partners and ensuring the success of manufacturing operations. Key Duties and Responsibilities Provides leadership in one or more technical areas Responsible for overall relationship with key suppliers of materials, technology and manufacturing resources Coordinates activities and leverages best practices across multiple projects and suppliers Manages and designs key packaging activities including packaging design and specification, equipment and tooling design and qualification, labeling,...

Vertex Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role that is central to our drug substance development mission. This is an exceptional opportunity for a seasoned pharmaceutical scientist with deep expertise in analytical and preparative chromatographic purification in both an R&D and cGMP environment— including large-scale preparative HPLC, supercritical fluid chromatography (SFC), Ion-pair reversed phase high-performance liquid chromatography (IP-RP_HPLC), ion exchange chromatography (AEX/CEX), and size exclusion chromatography (SEC). This individual will play a pivotal role in jumpstarting Vertex's emerging kilo-scale cGMP purification capabilities and laboratory,...

The Finance Manager, Commercial Manufacturing and Tech Ops (CMTO) is a key member of Vertex's Financial Planning & Analysis organization, responsible for our monthly/quarterly accounting close and supporting our Long Range Plan, Annual Budget and Quarterly Forecasts. This role partners closely with Commercial Manufacturing and Tech ops (CMTO) functions supporting our Biopharmaceutical Sciences and Manufacturing Operations (BSMO). This role partners closely with several functions across CMTO, providing financial direction and strategic insights to enable delivery against short-term and long-term goals, including identification of key value drivers and Business KPIs. The role ensures that all functional activities are appropriately reflected in...

Vertex is looking for a highly motivated candidate with experience in human pluripotent stem cell culture and directed differentiation protocols to lead our cell Foundry, a collaborative team focused on stem cell-derived islet (SC-islet) production, and associated workflows, enabling Vertex’s Cell & Gene Therapy pipeline with a current focus on Type-1 diabetes (T1D) program. This leader will manage and oversee a group of talented scientists and collaborations to advance T1D program goals and accelerate discovery. The ideal candidate is a strong and collaborative team leader who is detail-oriented, eager to learn, and innovate cell therapy processes. This role requires excellent...

Role Summary The Senior Manager, S2P Analytics & Master Data serves as the business owner for the Source-to-Pay (S2P) data and analytics foundation. This role ensures that supplier, taxonomy/category, preferred supplier, item/service, contract, risk, and related reference data are accurate, governed, scalable, and fit for purpose—while translating that data into trusted insights, executive narratives, self-service analytics, automation, and AI-enabled decision support. The role leads the business-side governance model, master-data lifecycle, data quality standards, analytics product portfolio, insight-generation capability, and enabling platform requirements across the S2P lifecycle. It partners closely with S2C and P2P Process & Platform Enablement, Strategy/Governance/Excellence, SBE, Finance,...

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our finance function is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. By joining our function, you will become part of a fast-moving, forward-thinking team to support the ongoing growth of a leader in the biotechnology industry. The Director of FP&A, DST Finance is a key member of Vertex's Financial Planning...

The Director, Supply Chain Management, Cell and Gene Therapy will lead the global commercial supply chain planning, strategy and operations for Vertex’s Type 1 Diabetes (T1D) program. The strategy includes long term capacity build plans across the CDMO network, supply risk assessments, slot management and accountability for end-to-end supply chain operations throughout the patient journey. The Director is responsible for establishing internal compliance and business processes in support of commercialization. The Director is accountable for building the processes, systems and people to ensure Supply Chain launch readiness. The Supply Chain Director has proven experience both managing and influencing large scale...

The Lead, Process Design & Standards is responsible for leading and advancing enterprise Source to Pay (S2P) process design and standards. This role serves as a senior process architect and steward for S2P, helping ensure clarity, consistency, scalability, and alignment with enterprise governance and strategy. Operating within the S2P Center of Excellence, this role focuses on how S2P should work across the organization and partners closely with Category and Sourcing teams, User Orchestration, and Execution Systems & Analytics COE teams to help ensure that process intent is translated into user experiences, systems, and insights—without owning execution, configuration, or operational reporting....

The Comparative Medicine Manager, Vivarium Operations is responsible for leading, supporting, and coordinating key aspects of the San Diego Research Site Vivarium and IACUC operations/management, with a primary focus on maintaining the day-to-day operations of the San Diego vivarium. This role serves as a critical partner to research teams by overseeing animal procurement, supporting IACUC-related processes, providing technical expertise for animal studies, and ensuring in vivo users are appropriately trained and onboarded. This person would serve as the Global Comparative Medicine liaison for San Diego. The position also plays a central role in the development, implementation, and continuous improvement of...

Vertex’s Data, Technology and Engineering (DTE) team is seeking a technology operations leader to join our Project Management and Strategic Operations group. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Associate Director, Strategic Operations - Technology will tackle the toughest challenges of how we work across DTE and cross-functionally to deploy technologies that scale our business. This role requires close partnership with technology leaders to identify gaps, design and implement improved processes, monitor outcomes and communicate...

The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers. This position is based in our Boston, MA location (Seaport area) and requires a hybrid work...

The Senior Administrative Assistant will serve as a trusted administrative partner to the Vice President, U.S. Government Affairs & Patient Advocacy; the Vice President, Federal Government Affairs; and the Executive Director, State Government Affairs. The role is responsible for complex calendar and travel management, meeting and event coordination, contracting and invoice administration, executive preparedness, and broader team operations. The successful candidate will work with a high degree of independence, judgment, discretion, and attention to detail while managing competing priorities and interacting professionally with senior internal and external stakeholders. Key Duties and Responsibilities Executive and Stakeholder Support Serve as a primary...

The Senior Medical Science Liaison (Sr MSL) will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide the...

Job Title Principal Business Analyst, Cell & Gene Therapy Commercial Technology Company Overview Vertex Pharmaceuticals is a global biotechnology company committed to investing in scientific innovation to create transformative medicines for people with serious diseases. Our teams combine science, technology, and operational excellence to advance therapies that can change patients’ lives. At Vertex, we foster a collaborative, inclusive environment where employees are empowered to solve complex challenges and drive meaningful impact across the enterprise. Role Summary Vertex is seeking a Principal Business Analyst, Cell & Gene Therapy Commercial Technology to join the Data, Technology and Engineering (DTE) team and play...

The Quality Analytics Manager utilizes data analysis skills and tools to evaluate Vertex operations, processes, and systems and recommends strategic process improvements based on research findings. This role is a key contributor in driving data-centric decision making within the Quality organization. The role also advises and supports business partners in design and delivery of data models and data analysis that enhance Vertex delivery and oversight. Key Duties and Responsibilities Identifies, analyzes, and interprets trends and patterns in complex data sets and prepares ongoing reports and data visualizations to support decision-making Develops and implements data analyses, data collection systems and other...

The Director, Patient Experience and Program Communications will serve as a key leader within the Pain Patient Support Team, responsible for defining and driving the strategy for patient-facing and stakeholder-facing communications that support access, fulfillment, and engagement. This role will lead efforts to simplify the patient access experience by translating operational complexity into clear, compelling, and actionable messaging and resources for patients, caregivers, healthcare providers, and internal stakeholders. We are seeking a candidate with a strong track record of leadership in US commercial roles, and demonstrated success leading complex cross-functional initiatives in highly regulated environments. The ideal candidate brings strategic...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Grant Manager is responsible for the overall management of the Pain grants and sponsorships program in Medical Affairs. This role will have responsibility for queries around the submission and review process, including cross-functional training to key internal stakeholders. This role will ensure processes and procedures are conducted according to standards and SOPs established by Compliance, Legal, and Medical Affairs. Key Duties and Responsibilities Provides oversight and full lifecycle management of incoming grant, humanitarian donations, sponsorship, exhibit and membership requests. This includes analysis and assessment of newly submitted external funding requests, oversight of grant committee meetings, contracting, milestone tracking/payments,...

The Salesforce Technical Architecture & Strategy Lead plays a pivotal role as a cornerstone of our Data, Technology, and Engineering (DTE) team. This role is instrumental in driving the success of the Cystic Fibrosis (CF) patient services platform built on Salesforce, which integrates critical capabilities to support our patient support teams. As a key leader, you will collaborate with cross-functional teams, design and implement cutting-edge solutions, and ensure the seamless operation of our Salesforce platform. Your expertise will directly impact our ability to deliver life-changing therapies to patients, while maintaining the highest standards of quality, compliance, and innovation. This is...

The Clinical Monitoring Associate Director is responsible for ensuring on-time monitoring and quality delivery of all required work assignments within the Clinical Monitoring function. Responsible for clinical monitoring training and quality oversight to ensure compliance with Good Clinical Practice and regulations. This position will also work closely with other functions in the Global Clinical Operations (GCO) team to report on clinical site management, important study specific and program updates, as well as process development for clinical monitoring. Key Duties and Responsibilities Manages and provides direction to CRAs and Lead CRAs, encouraging engagement, innovation and open communication while supporting Vertex and...

Role Summary The Senior Director, Human Resources Business Partner (HRBP) provides strategic HR partnership to leaders across Global Commercial Strategy, U.S. Pricing & Access / Government Affairs, Global Pricing, and Health Economics & Outcomes Research (HEOR) . Reporting to the Head of HR for Commercialization, this role focuses on talent strategy, organizational design, and supporting commercial transformation efforts . This role partners closely with the VP of Commercial Transformation to align people and organizational priorities with the broader Commercial Transformation agenda, and in support of the resources within the transformation office. Key Responsibilities HR Business Partnership Serve as a strategic...

The Senior Director, Integrated Customer Experience (ICX) Activation, is responsible for translating Vertex’s ICX strategy and priority customer journeys into the digital capabilities, platform requirements, and business roadmaps needed to activate them at scale. This role owns the ICX activation blueprint and roadmap and partners closely with DTE and I&A to enable orchestrated, personalized, and AI-enabled customer engagement across channels. The role also owns the business roadmap for website product strategy, marketing automation, customer data and activation capabilities, and the ICX agentic AI portfolio. This leader oversees external partners, drives cross-functional alignment, and leads a team of 10 direct reports....

Vertex is seeking experienced commercial leader to join our US Pain Business Unit to support a new treatment option for acute pain, Journavx. The Group Purchasing Organization (GPO) Account Lead will be responsible for supporting the development of the GPO strategy and establishing and maintaining relationships with key GPO decision makers. This role involves collaborating with GPO stakeholders to deliver access for the US business unit, with innovative pricing and access strategies. We are looking for candidates with a proven history of delivering exceptional results, building strategic relationships, and embodying the Vertex values to earn the trust of GPOs and...

The Operations and Analytics Associate Director leads sophisticated analyses, develops financial models, and generates insights to address strategic market access questions, presenting findings effectively and succinctly to leadership. The role requires the extraction and synthesis of relevant data to deliver timely insights into the underlying factors driving forecasts and variances to plan, while delivering forward-looking perspectives that inform and drive key business decisions— supporting both approved and potential future indications Key Duties and Responsibilities Work independently to surface insights from internal data sets and secondary sources that answer key business questions and inform access and commercial decisions Play a key...

Vertex is seeking a Sr. Manager, Contract Management to support a few business functions. In this role, you will manage the full contract lifecycle for a wide range of business agreements collaborating closely with colleagues across Legal, OBIE and Strategic Sourcing. The ideal candidate will bring strong contract administration experience, sound business judgment, and the ability to collaborate effectively with cross-functional stakeholders in a fast-paced environment. This position requires a highly organized professional who can balance competing priorities, ensure compliance with internal policies, and help drive efficient, consistent contracting processes. Key Duties and Responsibilities Lead the end-to-end contract lifecycle for...

We are seeking a unique individual with a passion for data and AI technology who can help our team drive forward enterprise-scale AI adoption of our data & AI platform. Vertex Pharmaceuticals is in a transformational period where we are accelerating our capabilities, technologies, and data to augment our scientific mission, enable Vertex to grow in scale, and continue to be on the forefront of science, medicine, and technology. As part of this effort, it is critical that users have data “at their fingertips”, with the patterns and technology to support AI adoption at scale. As a Senior Principal AI...

Vertex is seeking a Commercial Training, Senior Manager to enhance the skills, capabilities, and knowledge of customer-facing teams supporting reimbursement and patient access. This role is responsible for developing, implementing, and facilitating impactful training programs that support field readiness, onboarding, and ongoing capability development for field reimbursement and patient support audiences. The ideal candidate brings strong expertise in reimbursement, access, training strategy, and adult learning, with the ability to translate complex concepts into practical, field-relevant learning experiences. Work Model On-site or Hybrid Key Responsibilities Partner with cross-functional stakeholders to identify training needs and recommend learning solutions for field reimbursement teams...

Employee Relations Senior Manager The Employee Relations Senior Manager serves as a trusted advisor and strategic partner to leaders, HR, Legal, Compliance, and employees in fostering a fair, respectful, and compliant workplace. This role leads complex employee relations matters, workplace investigations, and policy interpretation while helping the organization proactively identify and address workforce risks and trends. The Senior Manager plays a critical role in safeguarding employee experience, ensuring consistent application of policies and practices, and influencing organizational culture through objective, evidence-based decision making. This individual will also help modernize and scale employee relations processes, tools, and reporting to improve...

The Associate Director, External Innovation reports into the Executive Director, External Innovation and Portfolio Operations , and is responsible for conducting scientific, clinical and commercial analysis, monitoring company/technology ev o lu t ion across the bio pharma landscape and contribute to the evaluation of collaboration /acquisition opportunities that are aligned with the corporate strategy. As a member of the External Innovation team, y ou will contribute across phases of evaluation of external opportunities , participate to cross-functional projects with the transaction s and alliance management teams , and manage cross-functional relationships to ensure communication and alignment across stakeholders. Responsibilities Conducts...

Our Medical Writing team at Vertex is in-house, and our Writers are strategic partners in our drug development process, collaborating with cross functional teams, authoring and driving clinical & regulatory documents to bring innovative new therapies to patients. This is a hybrid position which allows 2 days per week remote work and 3 days per week in our Boston Seaport office. Relocation assistance is available. The Director, Medical Writing Science has responsibility for the management, oversight, operation, and direction of a group within the department. This role is held accountable for the results of the group and the work performance...

The Manager, Disease Strategy Finance is a key member of Vertex's Disease Strategy Finance Team, providing financial and strategic insights to inform Disease Strategy Teams (“DSTs”) on key decisions. This role will work closely with Directors on the DST Finance team to conduct financial modeling, forecasting, and scenario-based valuations. The Manager, Disease Strategy Finance will also play a critical role in creation of the Annual Budget, Long-Term Plan (LRP), and other financial forecasts in collaboration with colleagues. The role will partner closely with members of the global COFO organization, including finance teams supporting R&D, Biopharmaceutical Sciences and Manufacturing, Corporate, and...

The Executive Assistant provides specialized, independent administrative/business support to 2-3 Vice Presidents supporting multi- therapeutic areas. Key Duties and Responsibilities Serves as the primary support professional for a Sr. Vice President, independently handling a full range administrative activities As the delegate for the executive, handles details of a highly confidential and critical nature related to the function/department Interacts regularly with senior leaders inside and outside the Company in coordinating the affairs of the executive Manages the executive's complex and detailed calendar, frequently coordinating logistics and sharing information with other assistants and leaders both internally and externally; coordinates complex travel and...

The Medical Writing Science Manager is responsible for preparing moderately complex clinical and regulatory documents and represents Medical Writing Science as a cross-functional team member at clinical study level activities. This role contributes scientific knowledge and analytical skills to the development of clinical regulatory documentation, under minimal supervision. Key Duties and Responsibilities Authors moderately complex clinical regulatory documents (e.g., including clinical study protocols, clinical study reports, investigator’s brochures, and sections of regulatory submissions) in partnership with key cross-functional stakeholders Serves as the lead Medical Writing Scientist for moderately complex clinical studies Supports Medical Lead with review and interpretation of clinical...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

This is a unique opportunity to shape the future of leadership at Vertex. As the Enterprise Talent Management Director, you will lead programs that ensure we have the leadership pipeline, succession strength, and talent capabilities needed to deliver on our long-term business ambitions. Partnering closely with senior leaders, HR Business Partners, and Centers of Excellence, you will drive enterprise talent reviews, succession planning, leadership pipeline development, executive onboarding, and senior leader development. This highly visible role combines strategic thinking, data-driven decision making, and influential partnership to identify and accelerate high-potential talent, strengthen leadership readiness, and build capabilities that fuel growth....

The Marketing Senior Manager will support the delivery of the marketing strategy by overseeing development of HCP and/or patient and caregiver tactics, and ensuring those tactics are delivered to customers effectively and monitored for effectiveness. Key Duties and Responsibilities Develops and updates marketing materials which are aligned with marketing strategy and business objectives (including branded websites, interactive visual aids, sales brochures, etc.) Enhances customer engagement by ensuring marketing pieces have been uploaded to the CRM platform, administering speakers programs, coordinating conference activities (including promotional booths, conference materials) Analyzes complex digital and print material usage metrics for performance reporting and assessing...

This role also prefers experience calling on the state of Hawaii. The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or...

Vertex is seeking an exceptional scientific leader to drive the development and incorporation of human disease models and assays into drug discovery programs. The Sr. Director, Pharmacology will lead a department responsible for the design, development, and execution of in vitro and in vivo assays that support the progression and optimization of human therapeutics, including assays used to determine drug potency, efficacy, and mechanism of action. This leader will also serve as a member of the San Diego biology leadership team and help shape site research direction and cross-departmental projects. Key Duties & Responsibilities Direct pharmacology strategy, including assays that...

Vertex is seeking a highly motivated Discovery Immunology Principal Research Scientist, to lead immunology discovery programs focused on autoimmune diseases. The successful candidate will shape scientific strategy, identify and validate therapeutic targets, investigate disease mechanisms, and advance early drug discovery. This role requires deep expertise in immunology, translational science, and experimental biology, as well as a record of leading complex research in a collaborative biotechnology environment. The position partners closely with teams in biology, translational sciences, bioinformatics, drug discovery, and project leadership. This is an on-site, laboratory-based role. Key Duties and Responsibilities Lead discovery immunology programs from target identification...

The Senior Administrative Assistant will serve as a trusted administrative partner to the Executive Director, Seattle Research Site Head. The role is responsible for calendar and travel management, meeting and event coordination, contracting and invoice administration, executive preparedness, and broader team operations. The successful candidate will work with a high degree of independence, judgment, discretion, and attention to detail while managing competing priorities and interacting professionally with senior internal and external stakeholders. Key Duties and Responsibilities Executive and Stakeholder Support Serve as a primary administrative point of contact for supported leaders, anticipating needs, applying sound judgment, and appropriately screening, routing,...

The Executive Medical Director, Clinical Development will provide high-level input on clinical development strategies to povetacicept renal programs, in conjunction with other relevant functional area leaders in Medical Affairs, Regulatory, Global Patient Safety, Clinical Operations, Exploratory Development, Commercial, Pharmaceutical Development, Research, Business Development, and Marketing. Initiate and lead innovative approaches to clinical development. Key Duties and Responsibilities Broad and comprehensive understanding of the drug development process Well-respected authority in the external clinical development community Provide clinical development recommendations to project teams, including optimizing study design and conduct for efficiency and effectiveness. Participate in planning for worldwide clinical development activities Provide...

We are seeking a highly motivated and experienced cell therapy leader to join our Vertex Boston Leiden Center location at the Director level. The Director, Stem Cell Research will work within the Type 1 diabetes (T1D) program to support our biology pipeline including molecular characterization of stem cell-derived islet manufacturing as well as discovery of novel biomarkers and associated assays. You will lead a highly skilled and motivated team coordinating collaborative research across multiple research groups. The Director should be a creative, innovative, self-motivated scientist with an outstanding record of bringing research discoveries from pre-clinical to clinical and/or commercial manufacturing....

Location Boston Fan Pier / Hybrid Department Nonclinical Safety / Toxicology Travel 30%–50% We are seeking a Nonclinical Toxicology Study Monitoring Scientist to play a critical role in supporting the safety assessment of both large and small molecule modalities including cell and gene therapies across the development pipeline by providing scientific, technical, and operational oversight of outsourced nonclinical studies. This individual will partner closely with project toxicologists, cross-functional internal teams, and external Contract Research Organizations (CROs) to help ensure studies are executed to high scientific and operational standards, in alignment with study objectives, timelines, and regulatory expectations. This role...

The Clinical Development Associate Medical Director will serve as the Medical Lead for clinical trials, working with cross-functional teams on trial strategy, design, execution, and reporting. In addition to oversight and accountability for the study as a whole, this role will serve as the internal primary Medical Monitor accountable for monitoring the safety of enrolled subjects and ensuring scientific integrity. The incumbent may participate in other projects to support the clinical development program. Key Duties and Responsibilities Participates in the development of Study Protocols, Investigator's Brochures, Clinical Development Plans and other key documents in conjunction with other line functions and...

The Principal Biostatistician will perform advanced scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with some guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Conducts advanced scientific and operational statistical work for multiple clinical trials, observational studies, or real world data (RWD) investigations, including the design, development and execution of the technical/statistical infrastructure....

The Director, Package Engineering leads a technical team of packaging engineers responsible for successful late-stage development, commercialization and supply of Vertex products. This role models leadership behaviors, builds an organization capable of ensuring future success, develops leaders, and drives efficiency and risk reduction into relevant internal and external processes. This role is a major contributor to the Manufacturing Science and Technology strategy development and to the collective success of Commercial Manufacturing & Technical Operations, Supply Chain, and Vertex. Key Duties and Responsibilities Responsible for technical packaging engineering and leverages knowledge to build alignment across technical areas or functions Supports Regulatory...

The Principal Analyst, Digital Discoverability & AI Optimization leads Vertex’s enterprise strategy and standards for digital discoverability across traditional search engines and emerging AI-powered answer and retrieval platforms. This role will define and scale capabilities that improve how Vertex websites, content, and digital assets are discovered, retrieved, interpreted, cited, and recommended. The role serves as the enterprise lead for Answer Engine Optimization (AEO), Generative Engine Optimization (GEO), AI search optimization, AI-ready website architecture, and LLM ingestion readiness. This position partners across Digital Customer Engagement, Commercial, Medical, Content Automation & Lifecycle, Omnichannel Activation, Digital Experience & Data Foundations, Analytics, Legal, Privacy,...

The Discovery Immunology Group is seeking a highly motivated Scientist to assist in the discovery and development of novel protein therapeutics to treat patients with autoimmune disease. This is a laboratory-based role where the successful candidate will contribute directly to research efforts by designing, executing, and analyzing experiments related to immune mechanisms, target validation, and therapeutic development. The position requires strong attention to detail and ability to multitask while working in a highly collaborative environment. Key Duties and Responsibilities Isolate, culture, and manipulate primary human immune cells and cell lines. Design and execute experiments to interrogate immune cell phenotype and...

Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. At our San Diego site, the Engineering & Applied Physics group is a dynamic, fast-paced team of 20 applied physicists and mechanical, electrical, and automation engineers. Together, we design and develop custom instruments that integrate cutting-edge technology and full automation to accelerate Vertex’s internal drug discovery pipeline. These instruments are tailored to specific project needs, enabling capabilities that are not commercially available. We are seeking an experienced and innovative Principal Scientist with expertise in optical design, microscopy, and functional...

Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Our teams bring together deep scientific expertise, advanced technologies, and a commitment to improving patient outcomes through discovery, development, and delivery of innovative therapies. Within Vertex, the Biomarkers organization plays an important role in advancing clinical development through biomarker research, assay development, and cross-functional collaboration. Role Summary Vertex is seeking a strategic, hands-on Biomarkers Senior Research Lab Scientist to develop and optimize biomarker assays for clinical trials at Vertex. The candidate will design and execute experiments within our...