Vertex Job Trends

The Medical Affairs Senior Director provides medical and scientific leadership in the assigned Therapeutic Area(s) (TA). This role will work closely with a cross-functional group to ensure that scientific and medical strategies are aligned with broader corporate and key stakeholder needs and will ensure the flawless execution of Nephrology medical plans. Key Duties and Responsibilities Critically interprets scientific data and determines the potential impact of new research on scientific and medical understanding of assigned products Develops medical affairs plans, including Launch and Life Cycle Management plans Shares country/regional insights with global teams to ensure global medical strategies and activities reflect...

We are seeking a highly strategic Digital Marketing Manager to join our pharmaceutical marketing team. This individual will partner closely with therapeutic area teams to shape and execute digital strategies that drive disease awareness, thought leadership, and stakeholder engagement across global markets. The role will utilize social listening, search analytics and other digital landscape analysis techniques to inform business strategy and optimize patient and HCP engagement. Key Responsibilities Digital Strategy & Landscaping Lead digital landscaping across assigned disease areas to identify emerging trends, competitive activities, audience behaviors, and innovation opportunities. Translate insights into actionable strategies to guide digital engagement, content...

The Manufacturing Operations Senior Associate is responsible for daily GMP manufacturing operations in the DPF, including the assembly, set-up, operation, disassembly, and cleaning of process equipment. Key Duties and Responsibilities Understanding of and strict adherence to cGMP requirements Compliance with all on-going training requirements Following Batch Records, SOPs, policies and all other relevant work instructions to ensure the successful and compliant operation of the drug product facility Interfacing with cleaning staff, Facilities/Operations, Quality, EH&S, Materials Management and the Release and Stability Laboratory to ensure facility operation Entering of data into log books and batch records Interfacing with computerized systems and...

We are seeking an accomplished and strategic leader to serve as Senior Research Fellow, DMPK Project Lead to guide the DMPK strategy for our Biotherapeutics portfolio including protein, antibody, ADC and cell and genetic therepies. The responsibilities will span from early research through clinical development. This leader will play a central role in ensuring that PK, bioanalysis, ADME, and translational PKPD insights are fully integrated into program decision-making and development plans. The ideal candidate will bring deep strategic and technical expertise in DMPK for one or more biotherapeutic modalities described above, have demonstrated leadership in a matrixed environment, and have...

The Associate Director of Internal Audit will support the development and execution of a risk-based audit plan to evaluate and improve the effectiveness of Vertex’s risk management, control, and governance processes. Reporting to the VP, Chief Audit Executive (CAE), this role will assist in implementing departmental strategy, contributing to annual functional goals, and overseeing portions of the SOX testing program. Key Responsibilities Maintain strong knowledge of Vertex’s core business and assist in developing a risk and control assurance program aligned with company objectives and risk appetite . Contribute to the development of departmental strategy, Audit Committee reporting, and departmental initiatives...

The Manufacturing Operations Support & Materials Management Manager is the accountable off-shift superintendent for cGMP cleaning and materials management support for cell manufacturing sites located in Boston and Cambridge. This role provides general oversight for Materials Management and Manufacturing Support functions. The Manager will partner with with Manufacturing Operations, Quality Assurance, Facilities, and Vertex managed service partners for troubleshooting and resolving issues as well as escalations to leadership for direction as necessary. As the off-shift superintendent, the Manager ensures compliant operations, cGMP cleaning, and materials management through proactive management. This leadership position monitors service level agreements with managed service partners...

The Associate Director, GMP Operational Quality is an advanced technical resource in the principles and application of quality assurance and compliance. This role is responsible for primary QA oversight of commercial drug substance manufacturing performed at Vertex’s external vendors as well as secondary quality support of commercial drug product manufacturing vendors. This position ensures robust sterile manufacturing controls, commercial supply continuity, support for global jurisdictional expansion, and high‑level combination product quality alignment. The incumbent will mentor team members to provide individual development in addition to efficient and valuable service to project teams. Key Duties and Responsibilities Collaborate with internal and...

The Business Engagement & Technology Senior Principal Analyst will serve as a strategic liaison between Marketing stakeholders and technical delivery teams, ensuring that business objectives are translated into actionable technology solutions. This role focuses on enabling and optimizing the Marketing Technology ecosystem—including Marketing Automation, Customer Data Platforms (CDP), and Web technologies—while maintaining compliance with legal and privacy regulations in a highly regulated industry. The ideal candidate combines deep technical expertise with strong business acumen and solution architecture principles. Key Duties and Responsibilities Business Engagement & Requirements Translation Execute the translation of defined business milestones, objectives , and KPIs from Marketing...

Director, Protein Therapeutics Vertex is seeking an accomplished and highly skilled scientific leader to join our Protein Therapeutics team in Seattle. This role will be critical in advancing our pipeline of innovative biologics from early development to clinical readiness in a dynamic, fast-paced, and highly collaborative environment. The ideal candidate will leverage deep scientific expertise, strong leadership and mentorship skills, and strategic vision to deliver transformational protein-based therapeutics for diseases with serious unmet medical need. Key Duties & Responsibilities Provide strategic leadership and scientific direction for a team specializing in protein engineering and production while fostering a culture...

The Senior Manager, Operational Quality is an advanced technical resource in the principles and application of quality assurance and compliance. The Senior Manager coordinates or executes activities on multiple complex projects and takes a role in the design and execution of new projects. This role is responsible for primary QA oversight of commercial drug product manufacturing performed at Vertex’s external vendors. The role also provides supporting oversight for commercial drug substance operations. This position ensures robust sterile manufacturing controls, commercial supply continuity, support for global jurisdictional expansion, and high‑level combination product quality alignment. Key Duties and Responsibilities Collaborate with internal...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Associate Director is recognized as an expert in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with regulatory requirements. This role is responsible for oversight and coordination of GMP activities in support of Commercial Release and serves as primary QA contact on cross-functional teams. The Associate Director manages and develops personnel and support department and functional activities. KEY DUTIES AND RESPONSIBILITIES The responsibilities of this role may include, but are not limited to, the following Responsible for oversight of analytical activities...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Meetings & Events Manager will be expected to monitor and provide guidance to Preferred Logistics Agencies (PLA) in addition to independently planning and executing a broad range of complex in-person and virtual internal and external meetings, including highly visible engagements for Senior Leadership. The role will advise stakeholders, assist in the development of meeting strategies and guide cross-functional planning teams to ensure meeting logistics and planned activities are aligned and support the overall meeting goals and objectives. The role will work collaboratively with the Global M&E Management Team to identify, build, and propose process efficiencies and best practices for...

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Povetacicept programs. Povetacicept (pove) is an enhanced, dual BAFF/APRIL inhibitor in pivotal development for the treatment of IgA Nephropathy (IgAN). The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical...

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our robust and complex R&D pipeline requires a focus on efficiency and prioritization as we scale. The Vertex finance function is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. We are investing in our ability to provide data-driven insights by organizing and automating financial data and processes to enable our growing...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

Employer Vertex Pharmaceuticals Incorporated JOB TITLE Analytical Development Principal Research Associate LOCATION 316 Northern Ave., Boston, MA, 02210 OPENINGS 1 DUTIES Design, develop, execute and analyze characterization and release assays for identity, purity, strength and potency of cell- based products. Multiple analytical platforms will be employed including RT-qPCR, SDS-PAGE, ELISA, Western blots, Flow cytometry, Flow-cam, ddPCR, Alphalisa and cell- based functional/ potency assays. Execute test methods in support of pluripotent stem cell Process Development activities. Troubleshoot, optimize, and trend assay performance. Report on project progress, write analytical development protocols and reports, provide recommendations to management. Identify, qualify,...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

Associate Director, Compliance Business Partner (Hybrid) Why Join Us? Vertex is a transformative biotechnology company that creates new possibilities in medicine to transform diseases and improve people’s lives. The company currently has approved products in cystic fibrosis, acute pain, sickle cell disease, and beta thalassemia. It has also developed a deep pipeline, investing billions of dollars into R&D over the past two decades. Vertex is seeking an experienced Compliance professional to join its Office of Business Integrity & Ethics (OBIE) as Associate Director, Compliance Business Partner providing support to our cell and gene, and kidney teams. OBIE is responsible for...

The Pharmacology Research Scientist works with a high degree of independence and is adept at conceptually outlining studies to design, execute and interpret assays to study the action of compounds on in vitro or in vivo disease biology. Completes work in a resourceful, self-sufficient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientific literature relevant to his/her scientific methodology or field(s) of technical expertise. This level captures both the Research organization’s entry level for staff with a research doctoral degree (PhD) and the advanced experimental expert leading one or more critical laboratory...

Vertex is seeking a hands-on, experienced team member with a passion for transformation and bringing new capabilities to our organization. The Associate Director, Accounting Transformation will manage and support initiatives that will modernize, streamline, and enhance processes impacting the Accounting and Finance teams. This new role is ideal for a motivated individual who thrives on working on meaningful projects while bringing stakeholders along through all facets of the journey. Key Duties and Responsibilities Manage daily aspects of various transformation projects while keeping deliverables on track to meet agreed upon timelines. Drive analysis of large data sets and provide clear interpretations...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

Vertex seeks a dynamic and experienced Medical Affairs physician executive to lead the new Disease Area of Hematology within the Global Medical Strategy group. This individual will be responsible for the development of Global Medical strategies for the first FDA approved CRISPR-cas9 medicine (Exa-Cel) for the treatment of Sickle Cell Disease and Infusion dependent B-Thalassemia, including the development of the life cycle management plan. The successful candidate will be an experienced people manager who is passionate about developing talent to whom the HEME Global Medical team will report to. The individual will partner with the International and North America regions...

The Director of Corporate Finance is a key member within the Finance organization, responsible for driving short term global planning, forecasting, and reporting processes —including budget development, consolidated performance reporting, and preparation of Board materials . This role partners closely with Finance leadership and cross‑functional stakeholders to provide financial direction and deliver strategic insights that enable achievement of Vertex objectives. The Director leads and develops a team of FP&A professionals , ensuring the delivery of accurate, timely, and actionable financial information that supports executive decision‑making and strengthens shareholder communication. Success in this role requires exceptional communication skills, the ability to...

Vertex currently operates at the forefront of rare disease scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), Sickle Cell Disease, Transfusion-Dependent Beta Thalassemia and Pain. In addition to clinical development programs in these commercialized areas, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in Type 1 diabetes, IgA Nephropathy (IgAN), APOL-1 Mediated Kidney Disease, and Duchenne Muscular Dystrophy, among others. The Director, Market Access Strategy (Heme) is accountable for leading, overseeing, and project managing the development of Market Access (MA) strategies,...

The Associate Director, Medical Writing Science manages the overall operations of a team or major project and implements this through effective leadership. This role provides guidance and leadership for document development for regulatory filings and coordinates the clinical sections of more complex regulatory submissions, including organization, content, and resource requirements. This role applies advanced technical expertise and develops solutions to complex problems, fosters interdisciplinary understanding, and integrates Medical Writing Science department activities with those of other departments. This is a hybrid role which allows for 2 days per week remote work and 3 days per week in the Boston Fan...

Job Posting Vertex Fellows Program Location San Diego, CA Flex Designation On-Site Designated Start Date August/September 2026 Application Deadline January 9, 2026, by 500 PM ET Please submit a CV/resume and cover letter with your application. Letters of Recommendation will be requested if invited to interview. About the Program The Vertex Fellowship is a unique, one-year training program for outstanding scientists and physicians passionate about solving unmet medical needs and advancing transformative science. Fellows join Vertex for a customized post-doctoral experience, gaining hands-on experience with real-world R&D challenges and benefiting from mentorship by Vertex leaders. This program is designed to...

Job Posting Vertex Fellows Program Location Boston, MA Flex Designation On-Site Designated Start Date August/September 2026 Application Deadline January 9, 2026, by 500 PM ET Please submit a CV/resume and cover letter with your application. Letters of Recommendation will be requested if invited to interview. About the Program The Vertex Fellowship is a unique, one-year training program for outstanding scientists and physicians passionate about solving unmet medical needs and advancing transformative science. Fellows join Vertex for a customized post-doctoral experience, gaining hands-on experience with real-world R&D challenges and benefiting from mentorship by Vertex leaders. This program is designed to provide...

About the Program The Vertex Physician Investigator (VPI) Program is a full-time, immersive opportunity for exceptional early-career physician-scientists who are passionate about solving unmet medical needs and advancing transformative science. Over two years, participants will complete four customized six-month rotations, receive intensive training, and benefit from direct mentorship by Vertex senior leaders. This program is designed to provide a broad understanding of the drug development process and prepare participants for future leadership roles in biotechnology. Program Highlights Four Rotations Over Two Years Two mandatory rotations Drug Discovery and Clinical Development Two elective rotations in other Vertex functions of the participant’s...

Vertex is seeking a strategic and collaborative Senior Director, Finance Technology to drive innovation and transformation across Financial Systems, with a focus on Tax, Treasury, and Accounting. This role sits within the Data, Technology & Engineering (DTE) organization and serves as a trusted partner to the CFO organization, aligning technology solutions with business strategies to deliver impactful outcomes. The ideal candidate will bring deep expertise in financial systems, strong stakeholder engagement capabilities, and a passion for enabling change through technology and AI. You will also be close to the technology and have the ability to lead from a technical first...

The Senior Director, HR Technology and Digital Innovation leads the strategic transformation of HR technologies and HR data platforms at Vertex. This role is responsible for architecting and executing a forward-looking digital roadmap that integrates AI, automation, and analytics to enhance employee experience, operational efficiency, and data-driven decision-making across the HR function. This role will lead a team responsible for architecture, design, development, support and future roadmaps for HR applications. These systems include as examples Workday, Cornerstone , GoodTime or a new Digital Assistant . The Senior Director, HR Technology and Digital Innovation will collaborate with senior leaders and other...