Vertex Job Trends

The Project Management & Strategic Senior Manager is responsible for multiple department projects and provides centralized operational support for the U.S. Commercial team. By partnering with departmental management and cross-functional project teams, the Senior Manager develops and maintains integrated project plans and operational processes in accordance with project/department objectives, and are within budget. The Senior Manager is also responsible for comprehensive communication, including status reporting, risk management, and department processes to cross-functional stakeholders and department senior leaders. The Senior Manager partners closely with the Chief of Staff, U.S. Commercial to execute on strategic, operational, and organizational matters. Key Duties and...

Vertex is seeking an experienced and strategic leader for the US Commercial Field Technology / CRM team. The Director, Field Technology is responsible for setting the strategy and leading execution for CRM and US commercial field technology enablement. This role ensures commercial field teams are equipped with effective, scalable technology that drives engagement, productivity, and decision-making. This leader will play a critical role in shaping and operating integrated technology and data solutions for the field , connecting business needs with CRM capabilities, processes, & governance. The role requires deep expertise in commercial systems leadership, CRM adjacent field operations processes and...

Vertex is seeking a Senior Research Scientist to join Analytical Development in Boston, MA . This role supports the advancement of transformative medicines by leading analytical chemistry activities across all stages of clinical development. The position is part of the Chromatography Subject Matter Expert (SME) team , focused on small molecules and synthetic peptides/oligonucleotides , with particular emphasis on drug substance, drug product intermediates, and drug product . Key Duties and Responsibilities Lead chromatographic method development, qualification, and validation activities. Partner with cross-functional project teams to design, oversee, and review analytical methods, validation protocols, and reports . Serve as a...

Company Overview Vertex Pharmaceuticals is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. We are committed to improving the lives of patients through bold science, advanced technology, and a collaborative, mission-driven culture. At Vertex, employees are empowered to solve complex challenges in an environment that values innovation, integrity, and excellence. The Principal Cybersecurity Engineer, Core Security Infrastructure is a technical leader responsible for shaping and advancing Vertex’s core security capabilities across network, cloud, application, AI, SaaS, and hybrid environments. This role serves as a deeply technical engineering leader focused...

The Stem Cell Research Scientist works with some independence and is adept at conceptually outlining studies to design and execute focused research projects or a series of complex experimental procedures including the development of human hematopoietic cell models and assays to evaluate targets and lead molecules for Vertex diseases. Completes work in a resourceful, self-sufficient manner and is able to design alternative approaches to achieve desired outcomes. Keeps current on the scientific literature relevant to scientific methodology or field(s) of technical expertise. This level captures both the Research organization’s entry level for staff with a research doctoral degree (PhD) and...

Through internal audits the Internal Audit Manager will identify risk areas, evaluate business process controls and complete test plans on operational audits. Additionally, this role will provide recommendations to improve the effectiveness and efficiency of operations and business systems. This role will also participate in ensuring that the yearly internal control review is brought to fruition by interacting with SOX testers, other stakeholders, and subject matter experts on special projects and the development and execution of departmental goals. Key Duties and Responsibilities Maintain strong knowledge of Vertex’s core business and assist in developing a risk and control assurance program aligned...

The Executive Director serves as a strategic leader responsible for defining and executing the Cell & Genetic Therapies (CGT) Quality vision, operating model, and organizational strategy. The role is accountable for ensuring quality readiness from early development through commercialization while building scalable, inspection-ready quality capabilities across internal manufacturing sites and external partner networks. The position drives enterprise CGT quality leadership, digital innovation, talent development, and risk-based decision making to support the successful delivery of life-changing therapies to patients. The role includes partnering with internal stakeholders to build & coordinate a phase appropriate quality roadmap to commercialization. Key Duties & Responsibilities...

Vertex is seeking a talented and motivated individual to join its Global Health Economics & Outcomes Research (HEOR) group in Boston, MA. The Health Economics & Outcomes Research Associate Director will participate in the shaping and execution of HEOR strategies that optimize the value proposition and supporting evidence of Vertex’s innovative renal pipeline asset, povetacicept , a dual inhibitor of the BAFF and APRIL pathways, currently in phase III. This position reports to the Senior Director Global HEOR, Kidney. Key Duties and Responsibilities Leads others to execute complex HEOR evidence generation including, cost-effective analysis and budget impact models, prospective...

The Senior Manager is a key member of Vertex's Financial Planning & Analysis team, providing financial direction and strategic insight to the US Pain Business Unit including identification of key value drivers and Business KPIs, helping the business unit deliver short term and long term goals, and influencing strategy. This role will help drive our annual budget process and will partner closely with functional teams to drive the financial performance management process (objective setting, budget vs. actuals, etc.). The role will also place a critical role in updating quarterly forecasts, with a focus on influencing business operations and decisions through...

The Director, External Manufacturing Cell and Genetic Therapies , role is to oversee and manage Vertex’s critical cell and gene therapy Contract Manufacturing Organizations (CMOs) and implement our vision for this business-critical function. The role requires a candidate with the breadth of professional experience and the drive to work with both internal and external partners to define and manage the ongoing cGMP supply of cell and gene therapy products that supports clinical through post-approval lifecycle management. The ideal candidate will understand the challenges and make proactive operational decisions, taking into consideration cross-functional and patient impact. This role requires a strong...

The Analytical Development Senior Research Associate independently performs complex experimental procedures designed through collaboration with their supervisor. Works collaboratively with the analytical team providing technical support to achieve program goals within established timelines and demonstrates excellent documentation skills. Independently performs troubleshooting as needed. Reports experimental findings and results to the team in an organized and clear manner. Authors method documents, analytical protocols and reports. Contributes to lab organization and efficient lab functioning. This individual will help advance transformative medicines treating the underlying cause of serious diseases by contributing to analytical activities for small molecule programs from preclinical through late stage...

The Finance Controller (Senior Manager) is a key member of Vertex’s Chief Operating & Financial Officer (COFO) organization, reporting to the Finance Controller (Director). The role serves as a strategic partner and subject matter expert for functional Finance teams including Research, Development, Biopharmaceutical Sciences & Manufacturing Operations, Commercial, G&A and Corporate Finance. The Senior Manager designs, implements, and leads continuous improvement of processes, policies, and procedures to advance an agile, strategic and compliant Finance organization. Key Duties and Responsibilities Lead strategic, cross-functional initiatives across the COFO organization, partnering with Finance, General Ledger Accounting, Technical Accounting, SEC Reporting, Record-to-Report Strategy &...

We are seeking a strategic, influential, and Data/Technology/AI-savvy Senior Director, HR Business Partner to partner directly with the Chief Digital & Information Officer (CDIO) and lead the people agenda for Vertex’s Data, Technology & AI organization. This role ensures the operating model, leadership capability, and enterprise talent strategy are in place to execute the Data/Tech/AI roadmap as AI transforms how work is delivered. This is a senior individual contributor role that leads through influence and serves as the primary people strategist for the Data/Tech/AI function. The role owns talent strategy and organizational effectiveness across the enterprise, driving transformation through...

The Executive Medical Director, Global Medical Lead (GML), Nephrology is a critical leadership role in Global Medical, responsible for the global medical strategy and implementation and tracking of global activities for a designated disease area(s). Key accountabilities include, but are not limited to, disease area specific Integrated Medical Plan development, including the publication plan, integrated evidence generation plan, global medical launch strategy and execution, scientific leadership, external medical expert engagement, and strategic alignment with commercial and other cross-functional business partners.. This leader reports directly to the VP, Global Medical and is a core member of the Global Medical leadership team....

Vertex is seeking a talented marketing professional to join the US Pain Business Unit to support the HCP experience with JOURNAVX . The Associate Director, HCP Experience will play a critical role in shaping and delivering best-in-class experiences for healthcare professionals (HCPs) as we continue the launch of JOURNAVX, a novel selective pain signal inhibitor of NaV1.8 in acute pain. This role will focus on designing and executing integrated HCP engagement strategies across key touchpoints of the education and prescribing experience . The individual will work closely with the Senior Director, HCP Marketing to bring the HCP strategy to life...

POSITION SUMMARY We are seeking a highly skilled and experienced Logistics Performance & Analytics Senior Manager to join our Global Logistics team. This person owns Logistics performance reporting, KPIs, TMS master data creation & maintenance, annual budget planning (inclusive of long rage planning), and freight accruals. This role is a critical end-user voice in the design of Logistics Data Products, and partners closely with the Global Logistics Business Process Owner (BPO) to ensure continuous improvement is grounded in real performance data. The role is also the reporting and performance lens through which Logistics contributes to the organization's broader Digital Transformation....

As an experienced Talent Acquisition specialist, the Associate Director implements and executes recruitment strategies and programs to attract best in class talent for critical openings. Establishes effective partnerships with search specialists and hiring managers to create and manage talent pipelines, coordinate recruiting initiatives, and leverage relationships with third party search partners. Key Duties and Responsibilities Design and implement approaches to identify and attract top talent to the organization inclusive of both organic attraction techniques and partnerships with external staffing partners. Build talent pipelines for near-term and longer-term organizational capability and capacity needs. Conduct proactive talent pipelining and sourcing initiatives leveraging...

Vertex is seeking a Director of Oracle ERP Delivery to lead the strategy, optimization, and governance of the Oracle E-Business Suite (EBS) platform that supports global finance operations. This role serves as a strategic partner to Accounting, and other business stakeholders using the platform to ensure Oracle E-Business Suite (EBS) and related financial systems are scalable, compliant, efficient, and aligned with business objectives. The ideal candidate brings deep expertise in Oracle EBS Financials, strong accounting and controllership knowledge, and a proven ability to lead system transformation, process improvement, and cross-functional initiatives in a regulated environment. This leader will help drive...

The Associate Director (AD) Quality Assurance (QA for QC) is an advanced technical resource in the principles and application of quality assurance and compliance. This role is responsible for the quality oversight of Quality Control and analytical development activities of Cell & Gene programs. Activities in scope of this role include release analytical testing, stability testing, and QA support for deviations and out of specification investigations. The role will have QA oversight of technical analytical method validations and analytical transfer activities internally /CDMOs through the program life cycle management. Key Duties and Responsibilities Analytical Lifecycle Management Serve as a Quality...

The GMP Operational Quality Senior Specialist is recognized as a subject matter expert in the principles and application of quality assurance and regulatory compliance. The incumbent supports or executes a wide range of straightforward activities, and supports new/existing project initiatives. The role works with a high degree of independence and coordinates GMP activities to provide QA Analytical support for commercial product stability programs and executes routine tasks and activities in support of QA Analytical function. Key Duties and Responsibilities Provides QA review of the GMP data in support of commercial product stability as required. Has a good understanding of stability...

Vertex is seeking a Commercial Training, Senior Manager to enhance the skills, capabilities, and knowledge of customer-facing teams supporting reimbursement and patient access. This role is responsible for developing, implementing, and facilitating impactful training programs that support field readiness, onboarding, and ongoing capability development for field reimbursement and patient support audiences. The ideal candidate brings strong expertise in reimbursement, access, training strategy, and adult learning, with the ability to translate complex concepts into practical, field-relevant learning experiences. Work Model On-site or Hybrid Key Responsibilities Partner with cross-functional stakeholders to identify training needs and recommend learning solutions for field reimbursement teams...

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. The finance organization is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. By joining Vertex’s Finance organization, you will become part of a fast-moving, forward-thinking team to support the ongoing growth of a leader in the biotechnology industry. The Finance Manager, Regulatory and Quality is a key member of Vertex's Financial...

Senior Manager , Cell and Gene Therapy Commercial Supply Chain – Commercial Manufacturing & Supply Chain, Vertex Pharmaceuticals (Boston) The Senior M anager o f Cell and Gene Therapy Commercial Supply Chain will drive slot management operations to support Vertex’s autologous c ell and gene therapy program. The slot management model include s dynamic , short range, and situatio nal planning and operations to allow visibility and patient scheduling . The Senior Manager will be responsible for establishing , maintaining, revising, and executing slot management rules and principles to ensure patients are appropriately scheduled within manufacturing capacity and regulatory requirements....

The Executive Director, Regulatory Strategy will serve as a seasoned regulatory leader with expert technical and tactical regulatory knowledge and advanced drug development expertise in Type 1 Diabetes (T1D). The incumbent will be responsible for overseeing the development and implementation of innovative global regulatory strategies for product development and commercialization of programs within the T1D portfolio. This position will manage a group of global/regional regulatory professionals with program leadership responsibilities. This role will play a major role in shaping cohesive regulatory strategy across the programs and ensuring effective integration of broad regulatory ideas/tactics supporting franchise strategy. Key Duties and Responsibilities...

The Vertex Biology team in San Diego seeks a strategic and innovative scientific and people leader to help advance therapies for serious diseases. As an ONSITE leader at our cutting-edge San Diego research facility, this high-impact role will develop and implement strategies to identify novel therapeutic approaches for areas of significant unmet medical need, guiding projects from concept through proof of concept, while collaborating closely with global research teams. Vertex has a track record of serial innovation. We work only on diseases where we have a deep understanding of the underlying cause in humans. By focusing on validated targets, creating...

Vertex is seeking a highly organized, proactive, and experienced Senior A dmin istrative Assistant to provide administrative support to the Legal & Compliance team. The Senior Administrative Assistant role provides specialized, independent administrative and business support to Senior Leaders. The ideal candidate brings exceptional judgment, professionalism, attention to detail, and the ability to independently manage multiple priorities. This individual will play a key role in supporting business operations, coordinating activities, collaborating across the department, and maintaining effective administrative processes in a fast-paced environment. Key Duties and Responsibilities Serves as the primary support professional for Senior Leaders, handling a full range...

Vertex currently operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF) patients. Our long-term commitment to advancing innovative therapies in other serious diseases continues to increase our need to grow and expand as an organization. Founded 30 years ago, Vertex has offices and research sites in North America, South America, and Europe. Vertex has consistently been recognized as one of the industry's top workplaces by leading publications such as Science Magazine, The Boston Globe, Boston Business Journal, San Diego Business Journal and The Scientist. The Global Pricing & Market...

This role leads a team responsible for the architecture, delivery, security, support, and continuous evolution of enterprise laboratory technology platforms — including laboratory Operational Technology (OT) such as information/cyber security, sensors, and IoT-enabled lab environments — across San Diego. It is also the single accountable Research Site Partner for San Diego the primary DTE relationship holder for the site's SVP and research leadership, and the front door through which site requirements are captured, shaped, and routed into the correct cross-functional platform backlog (Experiment Capture, Registration, LIMS, and peer DTE platforms in Research & Pre-Clinical, CMC/Manufacturing, and Supply Chain) This role...

This role is an early-career technical position supporting software (Model N) used across pricing, contracting, market access, government spend transparency reporting, gross-to-net, revenue management, rebates, and chargeback processing. The individual will be a hands-on technical resource responsible for learning the functional and technical domain, executing software configuration changes, supporting platform enhancements, troubleshooting issues, and helping ensure systems operate reliably and in compliance with software development lifecycle and change management standards. The ideal candidate will have a technical degree, 2–4 years of experience in software or a related technical discipline, strong understanding of the software development lifecycle, and working knowledge of...

This role leads laboratory technology support and continuous evolution across Seattle, and is the accountable Research Site Partner for Seattle the primary DTE relationship holder for the site's research leadership, and the front door through which site requirements are captured, shaped, and routed into the correct cross-functional platform backlog. Operating within highly regulated GxP and SOX environments, this role remains accountable for operational excellence, financial stewardship, and risk management across a complex laboratory technology landscape, including ownership of the site's annual operating budget. In parallel, the role carries accountability for local technology adoption, change management, and cross-site prioritization advocacy —...

The Executive Director, Data & Methods will lead a top-tier, multidisciplinary team of scientists and engineers to deliver foundational computational, AI, ML, and scientific methods and data capabilities that support research across all therapeutic modalities and scientific domains at Vertex. This leader will set AI and computational strategy that spans the full breadth of modern drug discovery and scientific therapeutic development; and will translate vision into scalable platforms, methods, and tools that serve every modality and measurably speed up discovery and translation, through the development of cutting-edge methods that leverage critical proprietary and public data to drive impact across our...

The Associate Director, GMP Operational Quality Assurance is a Quality leader and advanced technical resource responsible for strategic and operational Quality oversight across multiple complex programs. This role leads day-to-day quality operations, supports the execution of new initiatives, and applies sound judgment to resolve complex quality and compliance issues. The role provides Quality oversight for drug substance disposition from development through process performance qualification, ensuring decisions align with patient safety, product quality, regulatory expectations, and business continuity. This role serves as a visible Quality partner to Product Quality Leads, MSAT, Regulatory Affairs, operational stakeholders, CDMOs, and suppliers. The successful candidate...

Vertex is seeking experienced commercial leader to join our US Pain Business Unit to support a new treatment option for acute pain, Journavx. The Group Purchasing Organization (GPO) Account Lead will be responsible for supporting the development of the GPO strategy and establishing and maintaining relationships with key GPO decision makers. This role involves collaborating with GPO stakeholders to deliver access for the US business unit, with innovative pricing and access strategies. We are looking for candidates with a proven history of delivering exceptional results, building strategic relationships, and embodying the Vertex values to earn the trust of GPOs and...

General/ The Global Travel Operations, Senior Manager is responsible for overseeing and managing the day-to-day relationship with the Vertex Travel Management Company (TMC) vendor and the Travel Technology that supports it. This critical role will optimize vendor performance, drive operational efficiencies, monitor adherence to policies, and develop strong program controls to drive behaviors and policy compliance. The role will require significant global cross-functional collaboration to identify, build, and develop process efficiencies to enable scale and geographic expansion. The ideal candidate will possess advanced relationship-building skills, a proven ability to work with Senior Leaders, and navigate complex, high-pressure situations with professionalism...

As a key Team Manager and leader in the Strategic Sourcing function, the Director, Strategic Sourcing CoE Programs & Initiatives Leader is responsible for leading the strategic sourcing organizational through designing and driving key programs for value delivery and organizational AI readiness in partnership with the functional sourcing teams, business, DTE and other key stakeholders, elevating sourcing and procurement impact to the enterprise. The role provides people leadership to elevate the capabilities of the sourcing team, and has responsibility to help shape the future of an AI centered operating model. The ideal candidate understands Vertex systems and processes, is a...

This role will cover a territory including primarily Northern California and Oregon, and some CF centers / hospitals in Reno, NV and Alaska. The Senior Center Account Manager (CAM) will be responsible for achieving and maximizing territory sales goals by developing a strategic business plan, communicating thorough disease and product knowledge to healthcare professional customers (HCP’s), and utilizing effective and appropriate selling strategies. This role must understand market dynamics in a rare, complex disease state, demonstrate excellent judgment, and be motivated by the desire to improve patients' lives. This role will work cross-functionally within the sales/marketing team and compliantly across...

General/ The Associate Director – Shift Quality Operations is an advanced technical resource in the principles and application of quality assurance and compliance. The Associate Director provides quality leadership and oversight for manufacturing operations conducted across assigned shifts for cell therapy manufacturing. This role is responsible for ensuring ongoing compliance with cGMP , aseptic processing requirements, site quality systems, and regulatory expectations while enabling safe, reliable, and efficient manufacturing. The position partners closely with Manufacturing, Quality Assurance, Quality Control, MSAT, Engineering, Validation, and Supply Chain to support batch execution, deviation management, investigations, line clearance, contamination control, and continuous improvement. The...

The Senior Director, Clinical Pharmacology will serve as a Disease Area leader for Clinical Pharmacology. The Senior Director, Clinical Pharmacology will also manage the scientific functions and coordinate the activities of the Clinical Pharmacology function in collaboration with the other Disease Area leaders. The role’s responsibilities will include maintaining organizational processes across the group, influencing clinical program strategy, and integrating activities with other departments across the Global Research and Development organization, to help shape innovative and integrated clinical development plans. As a Disease Area leader, the Senior Director, Clinical Pharmacology will also direct Clinical Pharmacology efforts for biologics and other...

Vertex Pharmaceuticals operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), sickle cell disease, beta-thalassemia, and moderate to severe acute pain. Vertex also has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases, including programs in kidney diseases and Type 1 diabetes. Vertex is seeking an experienced Senior Director, US Market Access Strategy to lead market access initiatives for povetacicept (POVE) in IgA Nephropathy (IgAN) and future indications . This individual will guide the team responsible for developing and executing payer marketing,...

This role leads a team responsible for the architecture, delivery, security, support, and continuous evolution of enterprise laboratory technology platforms across LC1/2, Vertex's Cell & Gene Therapy (CGT) site. It is also the single accountable Research Site Partner for LC1/2 the primary DTE relationship holder for the site leadership, and the front door through which site requirements are captured, shaped, and routed into the correct cross-functional platform backlog. Operating within highly regulated GxP and SOX environments, this role remains accountable for operational excellence, financial stewardship, and risk management across a complex laboratory technology landscape, including ownership of the site's annual...

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer. Key Duties and Responsibilities Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools) Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group Demonstrates in-depth knowledge of clinical development and medical data Solves complex clinical trial reporting problems...

The Workforce Planning Director will lead Vertex’s enterprise workforce planning cycle, partnering with Strategic Finance, People Analytics, HRBPs, Talent Acquisition, Strategic Sourcing, and Digital & Technology on the long range plan (LRP), annual budget, headcount forecasts, and workforce reporting. The role will plan across internal, external, and digital labor, giving Vertex a consistent view of workforce demand, supply, capacity, cost, and mix. The Director will build the planning routines, models, and decision support needed to understand capacity, affordability, risk, and workforce mix across employees, contingent workers, vendor labor, and digital labor. The Director will also be expected to use AI...