Vertex Job Trends

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

Through internal audits the Internal Audit Manager will identify risk areas, evaluate business process controls and complete test plans. Additionally, this role will provide recommendations to improve the effectiveness and efficiency of operations and business systems. This role will also participate in ensuring that the yearly internal control review is brought to fruition by interacting with SOX testers, other stakeholders, and subject matter experts on special projects and the development and execution of departmental goals. Key Duties and Responsibilities Plans and performs financial, operational and, as applicable, IT audits; reviews related records for compliance with established and relevant reporting policies...

The Pain Territory Account Manager (PTAM) is responsible for establishing and maintaining relationships with key institutional decision makers and affiliated Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor ofNaVl.8 in acute pain. The PTAM develops deep & strategic account relationships within hospital settings, executing strategic account plans. This role will report into a Regional Field Leader and is responsible for leading engagement with 15-20 institutions (hospitals & ambulatory surgery centers) as well as select physicians within the hospital setting or hospital networks. This role will work alongside Territory Business Managers, a...

Vertex Pharmaceuticals is a global biotechnology leader committed to scientific innovation and the development of transformative medicines for people with serious diseases. Our finance function is a strategic enabler of Vertex's mission — providing the insights, rigor, and partnership that drive high-quality decisions across the enterprise. This is a high-visibility, high-impact role at the frontier of science and finance — where your work directly shapes how Vertex invests in advancing its pipeline from target identification through candidate nomination and beyond. We are seeking a strategic finance leader to serve as Director, R&D Finance, acting as the primary finance partner to...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Associate Director, GMP Operational Quality is responsible for oversight of team activities, development of personnel and ensuring quality of deliverables within department purview. The incumbent has comprehensive knowledge of principles and application of quality assurance and compliance. The incumbent is responsible for development of group goals and projects ensuring alignment with corporate goals and compliance with all regulatory requirements, refining goals and projects when necessary. The incumbent not only coordinates group responsibilities to ensure timely delivery to support business, but mentors team members to provide individual development in addition to efficient and valuable service to project teams. Key Duties...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Pain Territory Business Manager (TBM) is responsible for establishing and maintaining relationships with Health Care Professionals (HCPs) to promote the safe and effective use of JOURNAVX, a novel selective inhibitor of NaV1.8 in acute pain. The TBM reports into a Regional Field Leader and serves as a field representative for JOURNAVX within the community setting. The TBM will work closely with Pain Territory Account Managers (PTAMs) who are also field-based reps within the geographic area who serve as account managers within hospitals/health systems and are responsible for driving and pulling through hospitals/health system volume and access as well as...

Kickstart Your Career at Vertex! Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you’ll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We’re passionate about innovation, inclusion, and supporting your growth—inside and outside the lab. Why Vertex? Real Projects You’ll work on assignments that...

The Associate Director, Manufacturing Operations for Cell Therapy leads a team responsible for the execution of multi-product manufacturing operations. This role is accountable for the compliant production of cell therapy products and for the oversight, development, and training of the manufacturing team to ensure the efficient and effective delivery of therapies to patients. The role also cultivates and leverages cross-functional partnerships to identify and implement creative solutions to organizational opportunities and challenges. The Associate Director, Manufacturing Operations reports directly to the Senior Director, Manufacturing Operations and is a key member of the operational and manufacturing execution leadership team. This position...

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Supervisor, Manufacturing Operations leads first, second, or third-shift manufacturing activities, assigning work in alignment with detailed schedules and production plans. This role is responsible for daily cGMP operations, including equipment setup, assembly, operation, disassembly, and cleaning, while overseeing shift personnel and ensuring compliant, efficient execution of manufacturing activities. Key Duties and Responsibilities Lead and supervise daily manufacturing operations. Assign work to shift personnel based on detailed production schedules and operational plans. Oversee cGMP manufacturing activities, including equipment setup, assembly, operation, disassembly, and cleaning. Execute and witness batch record instructions during cGMP operations to ensure accurate and compliant manufacturing documentation....

The Executive Director, Commercial Analytics leads the Commercial Analytics Center of Excellence within US Commercial, providing enterprise-level oversight across forecasting, performance and strategic analytics, sub-national and field analytics, omnichannel and media analytics, and market research across North America, Global, and Early Pipeline. This role is a senior strategic partner to Commercial leadership and is accountable for elevating analytics from a tactical service into a core commercial capability that enables executive decision-making, launch excellence, and optimized investment. Key Duties and Responsibilities Lead the Commercial Analytics (CA) COE, overseeing ~20-25 FTEs organized by disease area (DA) verticals. Define enterprise analytics vision, operating...

The Associate Director, Manufacturing Operations for Cell Therapy leads a team responsible for the execution of multi-product manufacturing operations. This role is accountable for the compliant production of cell therapy products and for the oversight, development, and training of the manufacturing team to ensure the efficient and effective delivery of therapies to patients. The role also cultivates and leverages cross-functional partnerships to identify and implement creative solutions to organizational opportunities and challenges. The Associate Director, Manufacturing Operations reports directly to the Senior Director, Manufacturing Operations and is a key member of the operational and manufacturing execution leadership team. This position...

Vertex is seeking a talented individual to join our Analytical Development group in Boston, MA. As a member of an industry leading CMC team, this individual will help advance transformative medicines treating the underlying cause of serious diseases by conducting analytical chemistry activities for small molecule development programs. Responsibilities include characterization and stability assessment of drug substances, spray-dried dispersions, and drug products, as well as contributing scientifically to the resolution of broader drug development challenges in collaboration with other R&D functions. Expertise with laboratory techniques commonly used in the analysis of pharmaceutical products, including liquid chromatography (LC), is desired. Key...

Vertex is seeking a Senior Director, Global Commercial – Pain to play a key leadership role in shaping the global commercial strategy for our pain portfolio, with a strong focus on acute pain. This individual will lead critical strategic efforts across commercial opportunity assessment, long-range forecasting, target product profile development, and brand strategy. The successful candidate will bring deep expertise in market and customer insights, a strong understanding of the acute pain landscape, and the ability to translate complex market dynamics into clear, actionable commercial strategies. This role requires a highly strategic, collaborative leader who can work effectively across functions...

Vertex is seeking a talented individual to join the Engineering and Materials Science (EMS) department in Boston, MA. The successful candidate will be productive, results-oriented, and able to lead a diverse team of engineers and scientists to contribute to the successful development and scale-up of drug substance processes. Excellent interpersonal and organization skills as well as a high level of technical aptitude and creativity are required for success in this position. Key Duties and Responsibilities Responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of...

The Biostatistics Associate Director will perform sophisticated scientific statistical analyses in support of the company's Global Medicines Development and Affairs area with minimal guidance and mentoring on new and complex issues. The incumbent will completed work in a resourceful, self-sufficient manner and create alternative approaches to achieve desired results. The incumbent is capable of independent strategic and technical contributions. The incumbent should possess a good knowledge of related disciplines while performing Biostatistics activities with a drug developer mindset. Key Duties and Responsibilities Conducts all scientific and operational statistical work for multiple clinical trials, observational studies, or real world data...

The Clinical Development Medical Director will serve as the Medical Lead for Vertex clinical trials, working with cross-functional multidisciplinary study teams on clinical trial strategy, design and execution and serving as the Medical Monitor responsible for monitoring the safety of enrolled subjects on assigned trials. The incumbent will work on multiple trials in all Phases of clinical development, and may also participate in other selected projects in clinical development. Key Duties and Responsibilities Leads the development of Study Protocols, Investigator Brochures, Clinical Development Plans and other key study documents in conjunction with other line functions and with minimal guidance Serves...

The Manager, Quality Control is a key position that provides oversight of a variety of analytical functions that occur across the Vertex Manufacturing Center (VMC) and Leiden Center (LC1) supporting testing, and reporting of in-process, release, and stability samples. This role also ensures activities occur in an efficient and cGMP compliant manner. The role is a third shift position, Wednesday through Saturday, and will have formal people management responsibilities. Work shift Wednesday to Saturday, night shift between the hours of 900pm to 900am Key Duties and Responsibilities Independently manages a variety of laboratory program(s)/processes within the department (assay readiness, training,...

Senior Director, Regulatory Transformation & Innovation Job Summary The Senior Director, Regulatory Transformation & Innovation is a strategic leadership role within Regulatory Operations responsible for driving the implementation of transformation initiatives across Global Regulatory Affairs (GRA). This Senior Director will define and execute a transformation and innovation strategy that modernizes GRA-related processes by enabling new ways of working through application of digitization, AI/ML, analytics, automation, and technology solutions. Working across GRA and cross-functional partners, the Senior Director will identify, prioritize, and implement opportunities to enhance organizational effectiveness and drive business value, including through innovative approaches to regulatory document development, knowledge...

Vertex’s Automation of Machinery and Process (AMP) Team is seeking a Principal Process Engineer to develop cutting-edge manufacturing solutions for its Cell & Genetic Therapies programs. This pivotal role is at the forefront of automating complex processes in one of the most dynamic and rapidly evolving fields in biotechnology. You will work with a passionate team of engineers, scientists, and innovators united by a shared mission to push the boundaries of what’s possible in Cell & Genetic Therapy. This position plays a critical role in leading cross-functional workstreams for equipment & systems development, process optimization, and technology transfer to deliver...

The Manager, Temperature Controlled Logistics (TCL) is responsible for supporting the development, implementation, and continuous improvement of processes and procedures that enable reliable, compliant temperature-controlled logistics operations across Vertex. This role partners closely with Logistics Operations teams across all modalities, Logistics Service Providers, Quality Assurance, Packaging Engineering, Supply Chain, Technical Operations, Trade Compliance, Sourcing & Procurement, and internal and external manufacturing organizations to ensure product quality, regulatory compliance, and evolving business needs are consistently met. The successful candidate will help design, build, and sustain a robust logistics network that supports pipeline and commercial programs. Key responsibilities include evaluating and deploying...

The Senior Scientist, Analytical Sciences & Technology (AS&T), plays a critical role in the Commercial Manufacturing & Supply Chain team. You will be responsible for providing strong expertise with biological assays and analytical requirements to ensure launch readiness and lifecycle management for the commercial Cell and Gene therapy (CGT) portfolio. Key Duties and Responsibilities Accountable for the success of commercial analytical activities, prioritization, and execution to meet program commitments Subject Matter Expertise (SME) for ensuring the robustness of analytical methods and commercial testing requirements Author and/or review technical documents, including method SOP, study protocol and technical report Partners effectively with...

Company Overview Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. Our teams bring together deep scientific expertise, advanced technologies, and a commitment to improving patient outcomes through discovery, development, and delivery of innovative therapies. Within Vertex, the Biomarkers organization plays an important role in advancing clinical development through biomarker research, assay development, and cross-functional collaboration. Vertex is seeking a hands-on Biomarkers Research Lab Scientist to develop and optimize biomarker assays that support clinical trials at Vertex. This individual will design and execute experiments to characterize novel biomarkers...

Vertex Pharmaceuticals is seeking a highly motivated Packaging and Labeling Manager to support its growing commercial portfolio and robust pipeline of development-stage products. This role is responsible for managing end-to-end pharmaceutical artwork development and implementation activities, ensuring packaging and labeling materials are developed, reviewed, approved, and implemented accurately and on schedule. The Packaging and Labeling Manager will collaborate extensively with cross-functional stakeholders, including Regulatory Labeling, Quality Assurance, Supply Chain, Manufacturing Science & Technology (MS&T), external graphics providers, and packaging sites worldwide. The ideal candidate is a collaborative leader with strong project management skills, extensive knowledge of pharmaceutical artwork processes, and...

Vertex is looking for a lab-based Process Development Engineering Senior Scientific Associate to support process-development studies and the continued expansion of high-throughput laboratory capabilities. This position provides reliable operational support for bench-scale and high-throughput bioreactor studies, including the ambr250 platform and perfusion systems, and will execute critical laboratory activities such as equipment setup, media preparation and exchange, sampling, harvest operations, sample handling, and cell-culture support. The successful candidate will bring experience with mammalian and stem cell culture, bench-scale bioreactor operation, perfusion systems, and associated process-development workflows. The candidate will work closely with process development, engineering, and analytical partners to support...

The Process Development Engineering Principal Associate responsible for Manufacturing Science and Technology (MSAT) activities for cell therapy products. The candidate will provide cross-functional support in technology development and transfer from Development to Clinical Manufacturing and Process Performance Qualification including internal operations and potentially various CDMOs. They are also responsible for planning and implementing continuous improvement initiatives for life-cycle management working in cross-functional environment. Key Duties and Responsibilities Lead triage, investigation, and change control implementation as a Manufacturing Science and Technology functional area assessor and identify improvements, implement changes, and monitor clinical and commercial manufacturing processes. Manage the execution of deliverables,...

The Site Scheduling Supply Chain Sr. Specialist supports Vertex Cell and Genetic Therapies (VCGT) by managing day-to-day site scheduling processes and maintaining an aligned manufacturing schedule. This role coordinates across schedulers and stakeholders to provide visibility to schedule changes, priorities, and dependencies that may impact execution. The role also is responsible for RTMS support and day-to-day scheduling Teams channel coordination and updates. Key Duties and Responsibilities Maintain the site manufacturing schedule and coordinate across schedulers to ensure a single aligned plan. Identify schedule conflicts, cross-functional dependencies, and timing risks that may impact manufacturing execution, and drive alignment on required changes....

Vertex is seeking a talented individual to join our CGT Process Development team as a Scientist. The primary focus of this role is to lead the design and execution of process development studies for a cell-based drug candidate designed to treat diabetes. The Scientist will provide scientific and technical rigor in study design, execution, and data analysis and leveraging innovative technologies to deliver robust cell banking and hESC expansion processes. The ideal candidate has experience and understanding of embryonic stem cell biology and cell culture platforms. This is a full-time position based in our Boston, MA facilities. Key Duties and...

The GxP Site Engineering Senior Specialist will represent Global Engineering for Engineering needs from process, facility, instrumentation, and regulatory needs for Vertex GxP Facilities. The GxP Site Engineering Senior Specialist will collaborate with Facilities Operations, Advanced Manufacturing Engineering, Project Engineering, PMO, CMC teams and Site Leadership to meet all facility and manufacturing needs. This role will involve various aspects of equipment, and facility infrastructure-focused engineering efforts. Key Duties and Responsibilities Collaborate with scientific groups to learn and understand the evolving science and technology. Executes change management for facility and other support systems including commissioning and/or implementation of other related initiatives...

As a key leader within Strategic Sourcing and Enterprise Third-Party Risk Management (TPRM), the Director, Enterprise Third-Party Risk Management Operations & Governance is responsible for ensuring seamless operational execution of the enterprise TPRM program while preparing the organization for future scale and maturity. This role serves as the bridge between strategic program development and operational delivery, partnering closely with TPRM leadership, business stakeholders, Risk SMEs, sourcing teams, and managed service providers (MSPs) to ensure efficient execution, consistent governance, stakeholder engagement, and operational excellence across the third-party risk lifecycle. The Director will focus on integrating existing and emerging TPRM capabilities, strengthening...

The Materials Management Warehouse Senior Specialist provides oversight to warehouse operations and inventory logistics for cell and gene therapy manufacturing sites located in Boston and Cambridge. This role provides leadership to managed service providers performing material receipt, inventory control, kitting, transport, and issuance of raw materials and components. Additionally, this role oversees the receipt, transfer, storage, and pack-out of drug product. The Materials Management Specialist serves as a subject matter expert (SME) for Materials Management, serving as department liaison for scheduling, escalations, and quality events. 2nd Shift Monday - Friday 230pm -1100pm Key Duties and Responsibilities Subject Matter Expert (SME)...

MBA Summer Associate, Commercial The Vertex MBA Summer Associate Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are fearless" is in everything we do. Each summer, top MBA candidates from business schools around the world find all this and more through our MBA...

The Regulatory Labeling Associate Director will be responsible for strategic labeling and for executing on one or more products either at the global label-level (CCDS, USPI, EuSmPC) or in multiple ROW countries/regions for a given therapeutic area. This role may be accountable/responsible for specific business processes and may also be responsible for the development and management of a TLP with some guidance. Key Duties and Responsibilities Ensures compliance with labeling governance requirements and associated business processes. Leads label working groups and representing labeling at senior labeling governance meetings. Develops and maintains global product labeling for one or more products. This...

MBA Summer Associate Intern, Finance The Vertex MBA Summer Associate Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are fearless" is in everything we do. Each summer, top MBA candidates from business schools around the world find all this and more through our...

The Associate Director of GMP Operational Quality Assurance is an advanced technical resource and is recognized as an expert internally in the principles and application of quality and regulatory compliance. The individual adapts to new and multiple projects, effectively ensuring alignment with corporate goals and compliance with all regulatory requirements. The Associate Director of Quality Assurance is responsible for oversight of multiple Validation projects associated with Product Launch and Continuous Improvements, ensuring effective alignment with business timelines and compliance with relevant global regulatory requirements. This role is expected to work closely with business partners and stakeholders to ensure successful project...

The Materials Management Warehouse Senior Specialist provides oversight to warehouse operations and inventory logistics for cell and gene therapy manufacturing sites located in Boston and Cambridge. This role provides leadership to managed service providers performing material receipt, inventory control, kitting, transport, and issuance of raw materials and components. Additionally, this role oversees the receipt, transfer, storage, and pack-out of drug product. The Materials Management Specialist serves as a subject matter expert (SME) for Materials Management, serving as department liaison for scheduling, escalations, and quality events. 2 Shifts available Wednesday - Saturday 500am - 330pm or Sunday - Wednesday 500am -...

Overview The Revenue Accounting Manager will be responsible for overseeing the accounting for the order-to-cash process and the delivery of accurate and timely financial information relating to certain product revenues (including cell and gene therapies), gross to net accounts and accounts receivable to meet the operational needs and internal and external reporting requirements of the organization. The role will partner closely with members of Trade and Distribution, Market Access, Finance, Global Revenue Accounting, Government Pricing and Third-Party Partners. The Manager will also be responsible for identifying and driving process improvement initiatives including automation and data analytics. Key Duties & Responsibilities...

Vertex is seeking a Media and Buffer Preparation Supervisor to support media development and cell therapy manufacturing activities in Boston, MA. This role leads daily media, buffer, and stock solution preparation operations; ensures reliable, high-quality, and GMP-ready execution; and develops a strong, accountable team. The Supervisor will partner with cross-functional teams to improve processes, support scale-up and manufacturing readiness, and advance automation and continuous-improvement initiatives. Key Duties and Responsibilities Supervise daily media, buffer, and stock solution preparation, including scheduling, prioritization, troubleshooting, and escalation of issues. Lead, coach, train, and develop team members to strengthen technical skills, accountability, and operational discipline....

Vertex is seeking a talented individual to join our Process Development team as a Senior Scientist. The primary focus of this role is to lead the execution of process development and engineering studies for a cell-based drug candidate designed to treat diabetes. The Senior Scientist will be responsible for internal process development work, including process robustness and characterization studies, and may support manufacturing investigations. Importantly, the Senior Scientist will lead a weekend shift team to provide continuity for on-going studies over weekends and holidays. This is a full-time weekend and holiday shift position based in our Boston, MA facilities. The...

Cell, Gene and Biologics Therapies are a critical part of Vertex Pharmaceuticals, where research, development, and clinical manufacturing are highly integrated at our R&D site in Boston Seaport. Vertex is seeking a highly skilled technical leader to join our Process Development organization and lead drug product process development for cell and gene therapies. Reporting to the Vice President, Process Development, this role will set the scientific and technical strategy for formulation, cryopreservation, frozen storage, thaw, fill and finish, and administration-ready product presentation. The Senior Director will guide programs from early development through commercialization and build an integrated drug product capability...

The RWE Associate Director is an integral member of the RWE team who leverages expertise in epidemiology and real world data to develop fit-for-purpose observational research, and to inform internal and external stakeholders on natural history (NH) of disease and real world outcomes within their assigned therapeutic area. The RWE Associate Director works cross-functionally to support the execution of observational research across the portfolio. Key Duties and Responsibilities Independently lead focused/targeted research of epidemiology of specific disease areas, including NH of disease for business development and early development indications Lead data sourcing strategy for early development and early clinical indications...

We are seeking a highly skilled Principal Scientist, Analytical Development – Microbiology & Viral Safety to provide strategic and technical leadership for microbiology and viral safety testing across multiple development programs. This role will serve as the subject matter expert for microbiological and virological assays, supporting control strategy development, process development, regulatory submissions, and commercial readiness. The ideal candidate will bring deep expertise in microbiological and virological risk assessment, as well as assay evaluation, development, qualification, validation, and lifecycle management. This individual will also demonstrate strong cross-functional collaboration skills and a passion for scientific innovation. Key Duties and Responsibilities Serve...

POSITION SUMMARY We are seeking a highly skilled and experienced Logistics Performance & Analytics Senior Manager to join our Global Logistics team. This person owns Logistics performance reporting, KPIs, TMS master data creation & maintenance, annual budget planning (inclusive of long rage planning), and freight accruals. This role is a critical end-user voice in the design of Logistics Data Products, and partners closely with the Global Logistics Business Process Owner (BPO) to ensure continuous improvement is grounded in real performance data. The role is also the reporting and performance lens through which Logistics contributes to the organization's broader Digital Transformation....

The Senior Medical Science Liaison (Sr MSL) (Nephrology) for Vertex's broad Nephrology programs including IgAN and AMKD. The Sr MSL will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response...

Trade and Distribution Data and Analytics Manager Job Profile Summary Vertex is a biotechnology company with commercialized medicines for Cystic Fibrosis, Sickle Cell Disease, Transfusion Depended Beta-thalassemia and Acute Pain. Vertex also has a robust pipeline with programs in Type 1 Diabetes and targeted kidney diseases in phase 3 clinical trials, as well as several programs in phase 2 development. This opportunity is unique in the breadth of disease areas in scope as well as the product modalities which span small molecule, gene therapy, cell therapy, subcutaneous injections, and mRNA therapy, each requiring unique and innovative access and distribution strategies....

The Pharmacology Principal Research Associate is responsible for delivering high-quality, independent research to evaluate the effects of compounds on ex vivo and/or in vivo disease biology. This individual demonstrates advanced technical proficiency, strong attention to detail, and the ability to troubleshoot and adapt methodological approaches. A key focus of this role is the design, execution, and analysis of flow cytometry and cell sorting experiments, particularly using ex vivo samples collected from rodent and large animal studies. The ideal candidate will also have hands-on experience with basic in vivo techniques, including animal handling, dosing via multiple routes of administration (ROAs), perfusion,...

The Real World Evidence Manager is an integral member of the RWE team who leverages expertise in epidemiology, real world data, and other relevant disciplines to assess the natural history and real world outcomes for Vertex’s pipeline and portfolio products. The position will support cross-functional global observational research by providing methodological and analytical support for internal stakeholders, including Clinical Development, Global Medical Affairs, Global Patient Safety, and Government Affairs and Public Policy. The Manager will also execute on tactics related to the collection and/or analysis of real world data to inform relevant stakeholders such as regulatory affairs and clinical development....

The Supply Chain Specialist independently performs a broad range of activities supporting Vertex's Cell and Gene Therapy Supply Chain. This role is responsible for executing well-defined operational tasks and supporting projects of increasing complexity under limited supervision. Key responsibilities include managing turnaround times, tracking patient and batch-related milestones, monitoring deliverables, and ensuring patient supplies progress through each stage of the supply chain according to established processes. The Specialist collaborates closely with cross-functional partners including Finance, Regulatory, Commercial, Logistics, Quality Assurance (QA), Manufacturing Sciences and Technology (MSAT), Manufacturing, and other stakeholders. Key Duties and Responsibilities Participate in assigned project activities and...

The Associate Director, QC Technical Services – Small Molecule will lead the technical services group responsible for GMP release and stability testing activities at external laboratories supporting commercial small molecule programs at Vertex. The role is responsible for the development and maintenance of relationships with the external testing sites to provide strategic and operational oversight for QC activities, drive compliance, monitor performance and support continuous improvement activities. The role also includes operational oversight of quality event management, stability execution, regulatory support, and cross-functional collaboration to ensure uninterrupted commercial supply to patients. This position reports directly to the Senior Director of...

The Associate Director, Global Patient Safety (GPS) Individual Case Safety Report (ICSR) Therapeutic Area (TA) Lead is responsible for the oversight of global ICSR processing excellence and external business management within a specified TA. This position plans, executes and manages the technical aspects of Individual Case Safety Report (ICSR) processing and reporting, as well as provides oversight to external PV partners and vendors. GENERAL RESPONSIBILITIES AND REQUIRED SKILLS The Associate Director, Global Patient Safety ICSR TA Lead plays a key role in managing global ICSR processing excellence and external business management. This position serves as subject matter expert in global...

The Sr. Director, GCP Operational Quality will advance and provide strategic direction and oversight of the strategies, mechanisms, processes and capabilities for effective and proactive quality risk management across respective product/therapeutic program area(s) (e.g.; Cystic Fibrosis). This individual will serve as the GCP Operational Quality Lead and have overall responsibility for lifecycle review of risks to quality through ensuring appropriate oversight, mitigation strategies and plans enabling clinical quality outcomes and real time inspection readiness. This individual will provide strategic oversight and leadership for Quality Management Reviews, ensuring transparency for gaining insights regarding effectiveness of risk mitigation strategies/controls, proactive and sustainable...

Role Summary The Senior Manager, P2P Process & Platform Enablement is responsible for leading and advancing Procure-to-Pay (P2P) execution enablement, serving as a senior business lead for the platform, processes, and controls that support compliant, efficient purchasing and supplier transactions. This role leads the business-side enablement of P2P execution across requisitioning, approvals, catalogs, purchase orders, receiving, invoice processing and matching, and Supplier Information Management (SIM). The role helps ensure P2P execution is stable, well-controlled, scalable, and continuously improved, leveraging best in class practices and AI. Partners closely with Procurement Operations, Finance/AP, IT/Digital, and other COE towers to deliver reliable outcomes...

This role has overall accountability for strategic leadership and oversight of the end-to-end quality assurance strategy for proactive, risk-informed, and sustainable quality oversight and compliance with regulatory expectations across Vertex processes for clinical evidence generation and product vigilance. Responsibilities Serves as a strategic partner to functional leaders across product modalities responsible for Research (including both non-regulated and GLP work), Biomarker Development, and Diagnostics in assuring appropriate quality/compliance oversight of processes and systems supporting effective delivery of these programs and the rigor and integrity of associated data. Defines strategy for and oversees tactical execution strategic plan by direct reports...

Senior Director, Quality Data, Digital Systems & Compliance GxP Data Governance Data Integrity Master Data Computer Systems Assurance Quality Analytics General position summary The Senior Director, Quality Data, Digital Systems & Compliance, serves as a pivotal leader within the Quality organization. This role provides strategic vision and direction to advance frameworks, strengthen organizational capabilities, and scale models and operations across GxP Data Integrity, Data Governance, Quality Analytics, and Digital Systems Compliance (CSA/CSV) oversight. The position promotes leading practices, supports organizational growth, and enables adaptation to evolving industry expectations as well as advanced and emerging technologies. This...

Vertex is seeking a Senior Director, Head of Quality Control to lead QC strategy and external laboratory oversight for our Type 1 Diabetes Cell Therapy external manufacturing network . This leader will be responsible for building and scaling a robust QC partnership model supporting complex stem cell-derived therapies across CDMOs, external testing laboratories, and commercial/clinical supply operations. This role is focused on QC network oversight , including outsourced testing governance, method transfer into external laboratories, QC scheduling and budgets, sample management strategy, assay readiness, analytical performance monitoring, and QC compliance across the external network. What You’ll Do Lead Quality Control...

Senior Director, Head of Technical Services, T1D Cell Therapy Manufacturing Operations Department Manufacturing Operations Reports To Vice President, Type 1 Diabetes Manufacturing Operations Location Boston, MA and Portsmouth, NH Work Model Full time on site or hybrid eligible Vertex is seeking a Senior Director, Head of Technical Services to lead manufacturing-facing technical support for our Type 1 Diabetes Stem Cell Therapy Manufacturing Operations organization. This leader will oversee real-time GMP manufacturing support, troubleshooting, investigation support, operational process monitoring, manufacturing readiness, and implementation of approved process changes. The role requires deep experience in cell therapy manufacturing, strong people leadership, and the...

The Senior Manager, Manufacturing Technical Operations (MTO), is responsible for developing and executing the quality-record strategy for quality events supporting internal Cell and Gene Therapy (CGT) manufacturing. The role provides end-to-end oversight of quality events, including corrective and preventive actions (CAPAs), change controls, deviations, and analytical investigations. Responsibilities include reviewing quality metrics and trends; escalating cross-functional risks and issues; and establishing operational excellence practices that strengthen quality event compliance, investigation quality, timely record closure, and the sustainable implementation of CAPAs and change controls. The Senior Manager partners closely with Manufacturing, Quality Assurance, and other cross-functional stakeholders to promote a quality...

The Business Engagement Lead role within DTE to support our Clinical Development and Early Development business function role serves as a strategic partner between the business and DTE, translating business priorities into scalable, compliant, and fit-for-purpose systems, processes, and digital solutions. The Associate Director will work closely with business leaders and subject matter experts to understand priorities, shape capability roadmaps including AI related business use cases, and drive delivery of solutions that improve how our development organizations work. This role requires strong relationship management, business process acumen, and the ability to lead across a complex, matrixed, and regulated environment. Key...

General/ The Director, Global Trade Compliance is responsible for developing, owning, maintaining, and executing global trade compliance business processes, global trade management systems, and associated regulatory compliance activities. This role supports all Vertex supply chain models—including finished goods distribution, commercial manufacturing, clinical materials, development, research shipments, and other cross-border movements—across all geographies in which Vertex operates. The Director leads the Global Trade Compliance (GTC) business process and regulatory compliance team, resolving operational challenges, advancing strategic solutions, and ensuring consistent, accurate, efficient, and compliant customs declarations and related activities that support Vertex and the patients we serve. Key Duties & Responsibilities...

Vertex Pharmaceuticals is seeking a Principal Scientist, Microbiology to join the Analytical Science & Technology (AS&T) organization supporting biologics, cell therapy, and gene therapy programs. This role serves as the microbiology technical leader and subject matter expert responsible for microbiological methods and microbial control strategies supporting late-stage development and commercial products. The successful candidate will provide scientific leadership across microbiology method lifecycle management, external laboratory oversight, investigations, compliance, and continuous improvement to ensure robust, inspection-ready testing throughout the global network. Key Duties and Responsibilities Lead microbiology method qualification, validation, transfer, implementation, monitoring, and lifecycle management activities supporting biologics, cell therapy,...

The Package Engineering Associate Director has an established track record of both technical and project leadership, exerting broad influence both within and outside the Technical Operations organization. This role is accountable for effectively managing overall relationships with key partners and ensuring the success of manufacturing operations. Key Duties and Responsibilities Provides leadership in one or more technical areas Responsible for overall relationship with key suppliers of materials, technology and manufacturing resources Coordinates activities and leverages best practices across multiple projects and suppliers Manages and designs key packaging activities including packaging design and specification, equipment and tooling design and qualification, labeling,...

Vertex Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role that is central to our drug substance development mission. This is an exceptional opportunity for a seasoned pharmaceutical scientist with deep expertise in analytical and preparative chromatographic purification in both an R&D and cGMP environment— including large-scale preparative HPLC, supercritical fluid chromatography (SFC), Ion-pair reversed phase high-performance liquid chromatography (IP-RP_HPLC), ion exchange chromatography (AEX/CEX), and size exclusion chromatography (SEC). This individual will play a pivotal role in jumpstarting Vertex's emerging kilo-scale cGMP purification capabilities and laboratory,...

Vertex is looking for a highly motivated candidate with experience in human pluripotent stem cell culture and directed differentiation protocols to lead our cell Foundry, a collaborative team focused on stem cell-derived islet (SC-islet) production, and associated workflows, enabling Vertex’s Cell & Gene Therapy pipeline with a current focus on Type-1 diabetes (T1D) program. This leader will manage and oversee a group of talented scientists and collaborations to advance T1D program goals and accelerate discovery. The ideal candidate is a strong and collaborative team leader who is detail-oriented, eager to learn, and innovate cell therapy processes. This role requires excellent...

Role Summary The Senior Manager, S2P Analytics & Master Data serves as the business owner for the Source-to-Pay (S2P) data and analytics foundation. This role ensures that supplier, taxonomy/category, preferred supplier, item/service, contract, risk, and related reference data are accurate, governed, scalable, and fit for purpose—while translating that data into trusted insights, executive narratives, self-service analytics, automation, and AI-enabled decision support. The role leads the business-side governance model, master-data lifecycle, data quality standards, analytics product portfolio, insight-generation capability, and enabling platform requirements across the S2P lifecycle. It partners closely with S2C and P2P Process & Platform Enablement, Strategy/Governance/Excellence, SBE, Finance,...

Vertex is growing at a rapid pace with challenging and exciting opportunities for motivated professionals who are keen to contribute to the Vertex mission to invest in scientific innovation to create transformative medicines for people with serious diseases. Our finance function is integral to achieving our company’s strategic goals, providing critical insights and analysis in support of decision-making across the organization. By joining our function, you will become part of a fast-moving, forward-thinking team to support the ongoing growth of a leader in the biotechnology industry. The Director of FP&A, DST Finance is a key member of Vertex's Financial Planning...

The Director, Supply Chain Management, Cell and Gene Therapy will lead the global commercial supply chain planning, strategy and operations for Vertex’s Type 1 Diabetes (T1D) program. The strategy includes long term capacity build plans across the CDMO network, supply risk assessments, slot management and accountability for end-to-end supply chain operations throughout the patient journey. The Director is responsible for establishing internal compliance and business processes in support of commercialization. The Director is accountable for building the processes, systems and people to ensure Supply Chain launch readiness. The Supply Chain Director has proven experience both managing and influencing large scale...

The Lead, Process Design & Standards is responsible for leading and advancing enterprise Source to Pay (S2P) process design and standards. This role serves as a senior process architect and steward for S2P, helping ensure clarity, consistency, scalability, and alignment with enterprise governance and strategy. Operating within the S2P Center of Excellence, this role focuses on how S2P should work across the organization and partners closely with Category and Sourcing teams, User Orchestration, and Execution Systems & Analytics COE teams to help ensure that process intent is translated into user experiences, systems, and insights—without owning execution, configuration, or operational reporting....

The Comparative Medicine Manager, Vivarium Operations is responsible for leading, supporting, and coordinating key aspects of the San Diego Research Site Vivarium and IACUC operations/management, with a primary focus on maintaining the day-to-day operations of the San Diego vivarium. This role serves as a critical partner to research teams by overseeing animal procurement, supporting IACUC-related processes, providing technical expertise for animal studies, and ensuring in vivo users are appropriately trained and onboarded. This person would serve as the Global Comparative Medicine liaison for San Diego. The position also plays a central role in the development, implementation, and continuous improvement of...

Vertex’s Data, Technology and Engineering (DTE) team is seeking a technology operations leader to join our Project Management and Strategic Operations group. Project Management and Strategic Operations is charged with streamlining and simplifying the work of our data and technology teams and ensuring the successful deployment of new technologies across our global enterprise. The Associate Director, Strategic Operations - Technology will tackle the toughest challenges of how we work across DTE and cross-functionally to deploy technologies that scale our business. This role requires close partnership with technology leaders to identify gaps, design and implement improved processes, monitor outcomes and communicate...

The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers. This position is based in our Boston, MA location (Seaport area) and requires a hybrid work...

The Senior Medical Science Liaison (Sr MSL) will serve as a scientific liaison to the medical/academic community and is responsible for establishing and maintaining relationships with Health Care Providers/Professionals (HCPs) to ensure the appropriate dissemination of clinical and scientific information regarding Vertex' compounds in a timely, ethical and stakeholder-focused manner. The Sr MSL will contribute to shaping the medical plan by providing external stakeholders' insights, and contribute to the designing and execution of the Medical Affairs strategy and plan. The Sr MSL will engage HCPs in response to scientific educational and research needs with available Vertex resources, and provide the...

Job Title Principal Business Analyst, Cell & Gene Therapy Commercial Technology Company Overview Vertex Pharmaceuticals is a global biotechnology company committed to investing in scientific innovation to create transformative medicines for people with serious diseases. Our teams combine science, technology, and operational excellence to advance therapies that can change patients’ lives. At Vertex, we foster a collaborative, inclusive environment where employees are empowered to solve complex challenges and drive meaningful impact across the enterprise. Role Summary Vertex is seeking a Principal Business Analyst, Cell & Gene Therapy Commercial Technology to join the Data, Technology and Engineering (DTE) team and play...

The Quality Analytics Manager utilizes data analysis skills and tools to evaluate Vertex operations, processes, and systems and recommends strategic process improvements based on research findings. This role is a key contributor in driving data-centric decision making within the Quality organization. The role also advises and supports business partners in design and delivery of data models and data analysis that enhance Vertex delivery and oversight. Key Duties and Responsibilities Identifies, analyzes, and interprets trends and patterns in complex data sets and prepares ongoing reports and data visualizations to support decision-making Develops and implements data analyses, data collection systems and other...

The Director, Patient Experience and Program Communications will serve as a key leader within the Pain Patient Support Team, responsible for defining and driving the strategy for patient-facing and stakeholder-facing communications that support access, fulfillment, and engagement. This role will lead efforts to simplify the patient access experience by translating operational complexity into clear, compelling, and actionable messaging and resources for patients, caregivers, healthcare providers, and internal stakeholders. We are seeking a candidate with a strong track record of leadership in US commercial roles, and demonstrated success leading complex cross-functional initiatives in highly regulated environments. The ideal candidate brings strategic...

The Salesforce Technical Architecture & Strategy Lead plays a pivotal role as a cornerstone of our Data, Technology, and Engineering (DTE) team. This role is instrumental in driving the success of the Cystic Fibrosis (CF) patient services platform built on Salesforce, which integrates critical capabilities to support our patient support teams. As a key leader, you will collaborate with cross-functional teams, design and implement cutting-edge solutions, and ensure the seamless operation of our Salesforce platform. Your expertise will directly impact our ability to deliver life-changing therapies to patients, while maintaining the highest standards of quality, compliance, and innovation. This is...

The Clinical Monitoring Associate Director is responsible for ensuring on-time monitoring and quality delivery of all required work assignments within the Clinical Monitoring function. Responsible for clinical monitoring training and quality oversight to ensure compliance with Good Clinical Practice and regulations. This position will also work closely with other functions in the Global Clinical Operations (GCO) team to report on clinical site management, important study specific and program updates, as well as process development for clinical monitoring. Key Duties and Responsibilities Manages and provides direction to CRAs and Lead CRAs, encouraging engagement, innovation and open communication while supporting Vertex and...